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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | The lightning discharge显示文摘 | Bruce C E R Golde R H | 1941 | J Inst Elect1941，，88： | 1 |
| 3 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 4 | Engineering and kinetic characterisation of two glucosy|transferases from Arabidopsis thaliana 显示文摘 | Weis M Lim E K Bruce N C | 2008 | Biochimie2008，90，： | 1 |
| 5 | Sommargren laser doppler velocimeter for velocity and length measurements of moving surfaces 显示文摘 | BRUCE E T FRANK C D GARY E | 1984 | Applied Optics January1984，23，1： | 1 |
| 6 | Preoperative versus post- operative endoscopic retrograde cholangiopanereatography in mild to moderate gallstone pancreatitis显示文摘 | Lin C Simon LO Bruce E | 2000 | Ann Surger- y2000，231，1： | 1 |
| 7 | Quantitative analysis oflongitudinal response to aerosolized granulocyte -macrophagecolony-stimulating factor in two adolescents with autoimmunepulmonary alveolar proteinosis 显示文摘 | Terry E Bruce C Michael L | 2009 | Chest2009，135，3： | 1 |
| 8 | The lightning discharge显示文摘 | Bruce C E R Golde R H | 1941 | J Inst Electr Eng1941，88，： | 1 |
| 9 | Diet aberrant crypt foci and colorectal cancer显示文摘 | BRUCE W R ARCHER M C CORPET D E | 1993 | Mutat Res1993，，290： | 1 |
| 10 | Capital market imperfections, high- tech investment, and new equity financing 显示文摘 | Carpenter Robert E Petersen Bruce C | 2002 | Economic Journal2002，112，477： | 1 |
| 11 | Aerobic degradation of 2,4,6-trinitrotoluene by Enterobacter cloaca PB2 and by pentaerythritol tetranitrate reductase显示文摘 | French C E Nicklin S Bruce N C | 1998 | Applied and Environment Microbiology1998，64，8： | 1 |
| 12 | Does increased nerve length within the treatment volume improve trigeminal neuralgia radiosurgery? a prospective double-blind, randomized study显示文摘 | John C Flickinger Bruce E Pollock Douglas Kondziolka Loi K Phuong Robert L Foote Scott L Stafford L.Dade Lunsford | 2001 | International Journal of Radiation Oncology Biology Physics2001，，2： | 1 |
| 13 | A Long-recognized but underappreciated pathological feature of type 2 diabetes 显示文摘 | Steven E K Sofianos A Bruce C V | 1999 | Diabetes1999，48，： | 1 |
| 14 | Cooperatives' shares in farm industries:organisational and policy factors显示文摘 | CAVES R E BRUCE C | 1986 | Agribusiness1986，，1： | 1 |
| 15 | Contamination of refuges by Bacillus thuringiensis toxin genes from transgenic maize 显示文摘 | CHARLES F C Bruce E T | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，20： | 1 |
| 16 | Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo显示文摘 | Oates A C Bruce A E and Ho RiK | 2000 | Dev Biol2000，224，： | 1 |
| 17 | Electrochemical evaluation of mo-lybdenum disulfide as a catalyst for hydrogen evolution in microbialelectrolysis cells 显示文摘 | Justin C Tokash Bruce E Logan | 2011 | International journal of hydrogen energy2011，36，： | 1 |
| 18 | Petersen financing constraints and inventory investment:a comparative study with high-frequency panel data显示文摘 | Robert E Carpenier Steven M Fazzarl Bruce C | 2011 | The view of economies and statistics2011，，5： | 1 |
| 19 | In- formational Imperfections in the Capital Market and Macro--Economic Fluctuations 显示文摘 | Greenwald Bruce C Joseph E S Anfrew W | 1984 | American Eco- nomic Review1984，74，2： | 1 |
| 20 | Laser Doppler Velocimeter for Velocity and Length Measurements of Moving Surfaces 显示文摘 | Truax Bruce E Demarest Frank C Sommargren Gary E | 1984 | Applied Optics(S0003-6935)1984，23，1： | 1 |
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