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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 4 | Ethical Climate and Managerial Success in Russian Organizations 显示文摘 | Deshpande S P George E Joseph J | 2000 | Journal of Business Ethics2000，23，2： | 1 |
| 5 | Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy 显示文摘 | Christian W D Jorge E J Joseph S J | 1988 | Cardiovascular Research1988，22，： | 1 |
| 6 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 7 | Activation of nuclear factor-B during doxorubiocin-induced apoptosis in endothelial cell and myocytes is pro-apoptotic:the role of hydrogen peroxide显示文摘 | Wang S Kotamraju S Konoter E Kalivendi S Joseph J Kalyanaraman B | 2002 | Biochem J2002，367，3： | 1 |
| 8 | Induced ele- ctrokinetic transport in micro-nanofluidic interconnect devices显示文摘 | JIN X JOSEPH S GATIMU E N | 2007 | Langmuir2007，23，13： | 1 |
| 9 | Dividend taxation and intertemporal tax arbitrage 显示文摘 | Anton K Joseph E S | 2009 | Journal of Public Economics2009，，93： | 1 |
| 10 | Determinants of pre- term birth rates in Canada from 1981 through 1983 and from 1992 through 1994显示文摘 | Joseph KS Kramer MS Marcoux S e al | 1998 | N Engt J Med1998，339，20： | 1 |
| 11 | The peptidyl-prolyl isomerase Pin1 显示文摘 | JOSEPH J D YEH E S SWENSON K I | 2003 | Prog Cell Cycle Res2003，5，： | 1 |
| 12 | Catalytic hydroxylation of benzene and cyclohexane using in situgenerated hydrogen peroxide显示文摘 | Joseph E Tomas S | 2003 | Catalysis2003，203，24： | 1 |
| 13 | Geospatial video monitoring of nearshore benthic habitats of western Biscayne Bay (Florida) using the shallow-water positioning system (SWaPS)显示文摘 | Diego L Gregory D Joseph E S | | 0，，1： | 1 |
| 14 | Cytotoxicity of enantiomers of gossypol显示文摘 | JOSEPH A E MATLIN S A KNOX P | | 0，，03： | 1 |
| 15 | Privatization, information and incentives 显示文摘 | David E M Joseph E S | 1987 | Journal of Policy Analysis and Management1987，6，4： | 1 |
| 16 | Upper echelon theory (UET) a major determinant of information technology (IT) adoption by SMEs in Nigeria显示文摘 | Awa H O Eze S C Joseph E | 2011 | Journal of Sys- tems and Information Technology2011，13，2： | 1 |
| 17 | Enteric gila are multi potent in culture but primarily form glia in the adult rodentgut显示文摘 | Joseph NM He S Quintana E | 2011 | J Clin Invest2011，121，9： | 1 |
| 18 | Studies on melt processable biocomposites ofpoly-lactic acid显示文摘 | JOSEPH S DEENADAYALAN E MAHANWAR P A | 2015 | Journal of Polymers and the Environ- ment2015，23，3： | 1 |
| 19 | The prevalence of anxiety and mood problems among children Autism Asperger Syndrome显示文摘 | Joseph AK Peter S Susan E | 2000 | Autism2000，4，2： | 1 |
| 20 | A radix 4 delay commutator for fast Fourier transform processor implementation 显示文摘 | SWARTZLANDER E E YOUNG W K W JOSEPH S J | 1984 | IEEE Journal of Solid-State Circuits1984，19，5： | 1 |
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