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| 1 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Insect host location : a volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Science2005，10，6： | 1 |
| 5 | New Sand Additive Alternative for Veining in Thin-walled Castings显示文摘 | P L Zajac J Bruce | 1999 | AFS Transactions1999，107，： | 1 |
| 6 | Insect host location:A volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Sciences2005，10，： | 1 |
| 7 | Rainbow trout rearing performance, intestinal morphology, and immune response after long-term feeding of high levels of fermented soybean meal显示文摘 | Barnes M E Brown M L Bruce T | 2014 | Aquacuhure2014，76，4： | 1 |
| 8 | Transvenous pulmonary embolectomy by catheter device显示文摘 | Greefield L J Bruce T A Nicholus N B | 1971 | Ann Surg1971，74，： | 1 |
| 9 | Food scares and trust:a european study显示文摘 | MARIO M ALEXANDRA L BRUCE T W | 2008 | Journal of Agricultural Eco-nomics2008，59，1： | 1 |
| 10 | Choice Situation,Refocusing,and Post-Bankruptcy Performance 显示文摘 | Divid D D James J H Bruce T L | 2002 | Journal of Management2002，28，5： | 1 |
| 11 | Properties of enteric sodium valproate pellets 显示文摘 | BRUCE L D PETEREIT H U BECKERT T | 2003 | Int J Pharm2003，264，： | 1 |
| 12 | Assessment of the sources of error affecting the quantitative accuracy of SPECT imaging in small animals显示文摘 | Andrew B Hwang Benjamin L Franc Grant T Gullberg Bruce H Hasegawa | 2008 | Physics in Medicine and Biology2008，，9： | 1 |
| 13 | The impact of depressive symptomatology on physical disability:MacArthur Studies of Successful Aging 显示文摘 | BRUCE M L SEEMAN T E MERRILL S S | 1994 | Am J Public Health1994，84，： | 1 |
| 14 | Development of a pheromone trap monitoring system for orange wheat blossom midge, Sitodiplosis mosellana, in the UK显示文摘 | Bruce T Hooper A M Ireland L | 2007 | Pest Management Science2007，63，： | 1 |
| 15 | Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a,micronucleus and Comet assays integrated into 28-day repeat dose studies显示文摘 | Shi J Krsmanovic L Bruce S Kel y T Paranjpe M Szabo K | 2011 | Environ Mol Mutagen2011，52，9： | 1 |
| 16 | Insect host location : avolatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trend Plant Sci2005，10，26： | 1 |
| 17 | Insect host location : a volatile situation显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Science2005，10，6： | 1 |
| 18 | Nitric oxide control of steroidogenesis:endocrine effecte of N+G-Nitro-L-arginine and comparisons to alcohol显示文摘 | Michael L Bruce N Rosalie T | 1992 | Life Science1992，50，6： | 1 |
| 19 | Insect host location:A volatile situation显示文摘 | BRUCE T J A WADHAMS L J WOODCOCK C M | 2005 | Trends in Plant Science2005，10，： | 1 |
| 20 | WARLOC: A high-power coherent 94 GHz radar显示文摘 | George J L Mai T N Bruce G D | 2008 | IEEE Trans on Aero Elect2008，44，3： | 1 |
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