|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 2 | Evaluation of copper avail- ability to plants in copper- contaminated vineyard soils显示文摘 | L A Brun J Makllet P Hinsinger | 2001 | Environ- mental Pollution2001，111，： | 3 |
| 3 | Fundamental pathological lesions in vascular dementia显示文摘 | Brun A Engiuund E | 1996 | Acta Neurol Suppl1996，168，： | 1 |
| 4 | Oocyte bone morpbogenetic protein 15,but not growth differentiation factor 9,is increased during gonadotropin-induced follicular development in the immature mouse and is associated with cumulus oopboras expansion显示文摘 | Brun V Gongeon A | 2006 | Biol Reprod2006，75，6： | 1 |
| 5 | Physical and chemical characteristics of the active layer and permafrost, Herschel Island, western arctic coast, Canada显示文摘 | Kokelj S V Smith C A S Brun C R | 2002 | Permafrost and Periglacial Process2002，13，： | 1 |
| 6 | DNA recovery from soils of diverse composition 显示文摘 | Zhou J Bruns M A Tiedje J M | 1996 | Appl Environ Micro biol1996，62，： | 1 |
| 7 | Regional pattern of degeneration in Alzheimer's disease:neuronal loss and histopathological grading显示文摘 | Brun A Englund E | 1981 | Histopathology1981，5，5： | 1 |
| 8 | Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice显示文摘 | Mallat Z Gojova A Brun V | 2003 | Circulation2003，108，： | 1 |
| 9 | Climate changes and trends in phenology of fruit trees and field crops in Germany, 1961-- 2000显示文摘 | CHMIELEWSKI F M MULLER A BRUNS E | 2004 | Agricultural and Forest Meteorology2004，121，1： | 1 |
| 10 | DNA recovery from soils of diverse composition 显示文摘 | ZHOU J Z BRUNS M A TIEDJE J M | 1996 | Appl Environ Microbiol1996，62，2： | 1 |
| 11 | Ammonia: a candidate for nitrogen transfer at the myeorrhizal interface 显示文摘 | Chalot M Blaudez D Brun A | 2006 | Trends in Plant Science2006，11，： | 1 |
| 12 | DNA recovery from soils of diverse composition 显示文摘 | ZHOU J BRUNS M A TIEDJE J M | 1996 | Appl Environ Microbiol1996，62，： | 1 |
| 13 | High-yield expression of a viral peptide vaccine in transgenic plants显示文摘 | Brun A Wigdorovitz A | 2001 | FEBS Lett2001，488，12： | 1 |
| 14 | Techniques of coilingcerebral aneurysms显示文摘 | Aletich V A Thornton J etal | 2000 | Surg Neurol2000，53，： | 1 |
| 15 | Complications after effects of conizations and follow-up of patients after treatment; Assessment of 3 conizations methods显示文摘 | Youbi A Hocke C | 2002 | J Gynecol Obstet Biol Repord (Paris)2002，31，6： | 1 |
| 16 | Specific abrogation of transforming growth factorbeta signaling in T cells alters atherosclerotic lesion size and composition in mice显示文摘 | Gojova A Brun V Esposito B | 2007 | Blood2007，102，12： | 1 |
| 17 | Stereochemistry of cyclic compounds显示文摘 | Bruns K Conrad J Steigel A | 1979 | Tetrahedron1979，35，： | 1 |
| 18 | Psychosocial support for pulmonary rehabilitation in patients with chronic obstructive pulmonary disease 显示文摘 | Ninot G Brun A Queiras G | 2003 | Rev Mal Respir2003，20，4： | 1 |
| 19 | Nucleosomes are major T and B ceil autoantigens in sys-emic lupus erythematosus显示文摘 | Bruns A Blass S Hausdorf G | 2000 | Arthritis Rheum2000，43，10： | 1 |
| 20 | DNA recovery from soils of diverse composition 显示文摘 | Zhou J Z Bruns M A Tiedje J M | 1996 | Applied and Environmental Microbiology1996，2，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员