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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice显示文摘 | Hea Jin Park Dana A. DiNatale Min-Yu Chung Young-Ki Park Ji-Young Lee Sung I. Koo Meeghan O’Connor Jose E. Manautou Richard S. Bruno | 2011 | The Journal of Nutritional Biochemistry2011，，4： | 2 |
| 3 | Mn partitioning during the intercritical annealing of ultrafine-grained 6% Mn transformation-induced plasticity steel显示文摘 | Seok-Jae Lee Seawoong Lee Bruno C. De Cooman | 2010 | Scripta Materialia2010，，7： | 2 |
| 4 | Living donor liver transplantation with body-weight more or less than 10 kilograms显示文摘AIM: To compare the outcomes of pediatric patients weighing less than or more than 10 kg who underwent liver transplantation.METHODS: Data for 196 pediatric patients who underwent living donor liver transplantation between June 1994 and February 2011 were reviewed retrospectively.The information for each patient was anonymized and de-identified before analysis. The data included information regarding the pre-transplant conditions, intraoperative fluid replacement and outcomes for each patient. The 196 patients were divided into two groups: those with body weights of less than 10 kg were included in group 1(G1; n =101), while those with body weights of more than 10 kg were included in group 2(G2; n = 95). For each group, the patients' ages, body weights, heights,pediatric end stage liver disease scores, anesthesia times, and warm and cold ischemic times were analyzed. In addition, between-group comparisons were also made. Mann-Whitney U tests were used to compare all the variables except for complications and survival rates, which were analyzed using χ 2 tests and Kaplan-Meier tests, respectively.RESULTS: The general medical conditions of the G1patients were worse than those of the G2 patients, as shown by the higher pediatric end stage liver disease scores and poorer Z-scores. In addition, the preoperative Hb and serum albumin levels were all lower for the G1 patients than for the G2 patients. The G1 patients also had significantly more intraoperative blood loss than the G2 patients. In addition, the intraoperative fluid requirements for the G1 patients,including leukocyte poor red blood cell transfusions,5% albumin infusions and crystalloid infusions, were significantly higher than those for the G2 patients. The risk of intraoperative portal vein thrombosis was higher for the patients in G1 than for those in G2. However,the one-year survival rates(95.9% and 96.8% for G1 and G2, respectively) and three-year survival rates(94.9% and 94.6% for G1 and G2, respectively) for both groups were similar.CONCLUSION: Patients weighing less than 10 kg typically have poorer conditions, but their survival rates are comparable to those of children weighing more than 10 kg. | Sheng-Chun Yang Chia-Jung Huang Chao-Long Chen Chih-Hsien Wang Shao-Chun Wu Tsung-Hsiao Shih Sin-Ei Juang Ying-En Lee Bruno Jawan Yu-Feng Cheng Kwok-Wai Cheng | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 5 | SINGLE IMAGING MODALITY EVALUATION OF LIVING DONORS IN LIVER TRANSPLANTATION: MAGNETIC RESONANCE IMAGING1显示文摘 | Yu Fan Cheng Chao Long Chen Tung Liang Huang Tai Yi Chen Tze Yu Lee Yaw Sen Chen Chih Chi Wang Vanessa de Villa Shigeru Goto Yuan Cheng Chiang Hock Liew Eng Bruno Jawan Hak Kim Cheung | 2001 | Transplantation2001，，9： | 1 |
| 6 | Mn partitioning during the intercritical annealing of ultrafine-grained 6% Mn transformation-induced plasticity steel显示文摘 | Seok-jae Lee Seawoong Lee Bruno C De Cooman | 2010 | Scripta Materialia2010，64，7： | 1 |
| 7 | Stress Response to Hepatectomy in Patients with a Healthy or a Diseased Liver显示文摘 | Albert Kuo-Mao Lan M.D. Hsiang-Ning Luk M.D. Ph.D. Shigeru Goto M.D. Ph.D. Shyr-Ming Sheen Chen M.D. Hock-Liew Eng M.D. Yaw-Sen Chen M.D. Vanessa H. Villa M.D. Ph.D. Chih Chi Wang M.D. Yu-Fen Cheng M.D. Chao-Long Chen M.D. Ju-Hao Lee M.D. Bruno Jawan M | 2003 | World Journal of Surgery2003，，7： | 1 |
| 8 | Austenite stability of ultrafine-grained transfommtion-induced plasticity steel with Mn partitioning显示文摘 | Seawoong Lee Seok-jae Lee Bruno C De Cooman | 2011 | Scripta Materialia2011，65，3： | 1 |
| 9 | Endoscopic sphincterotonay for sphincter of oddi dysfunction: inefficacious therapy for a fictitious disease显示文摘 | Dawwas MF Bruno M J Lee JG | 2015 | Gastroenterology2015，148，2： | 1 |
| 10 | Genotype-phenotypecorrelation of paroxysmal nonkinesigenic dyskinesia 显示文摘 | Bruno MK Lee HY Auburger GW | 2007 | Neurology2007，68，： | 1 |
| 11 | Interventional radiologic procedures in liver transplantation显示文摘 | Yu Fan Cheng Yaw Sen Chen Tung Liang Huang Vanessa de Villa Tai Yi Chen Tze Yu Lee Chih Chi Wang Yuan Cheng Chiang Hock Liew Eng Hak Kim Cheung Bruno Jawan Shih Hor Wang Shigeru Goto Chao Long Chen | 2001 | Transplant International2001，，4： | 1 |
| 12 | Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer显示文摘 | Maria A Kouvaraki Suzanne E Shapiro Bruno D Fornage Beth S Edeiken-Monro Steven I Sherman Rena Vassilopoulou-Sellin Jeffrey E Lee Douglas B Evans | 2003 | Surgery2003，，6： | 1 |
| 13 | Mechanical behavior of multi-phase 12% Mn TWIP steel 显示文摘 | Lee Sangwon Lee Seok-Jae De Cooman Bruno C | 2012 | Mater and Design2012，33，3： | 1 |
| 14 | Posttraumatic elbowstiffness : evaluation and management 显示文摘 | Bruno RJ Lee ML Strauch RJ | 2002 | J Am Acad OrthopSurg2002，10，2： | 1 |
| 15 | Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia 显示文摘 | Bruno MK Lee HY Auburger GW | 2007 | Neurology2007，68，21： | 1 |
| 16 | Characteristics of Li 2 S 8 -tetraglyme catholyte in a semi-liquid lithium–sulfur battery显示文摘 | Marco Agostini Dong-Ju Lee Bruno Scrosati Yang Kook Sun Jusef Hassoun | 2014 | Journal of Power Sources2014，，： | 1 |
| 17 | Mn partitioning during the intercritical annealing of uhrafine-grained 6% Mn transformation-induced plasticity steel 显示文摘 | Lee Seok-Jae Lee Seawoong Bruno C De Cooman | 2011 | Scripta Materialia2011，64，7： | 1 |
| 18 | Austenite stability of ultrafine-grained transformation-induced plasticity steel with mn partitioning 显示文摘 | Seawoong lee Seok-jae lee Bruno C De cooman | 2011 | Scripta Materialia2011，65，3： | 1 |
| 19 | Austenite stability of ultrafine-grained transformation-induced plasticity steel with Mn partitioning 显示文摘 | Lee Seawoong Lee Seok-Jae Bruno C De Cooman | 2011 | Scripta Materialia2011，65，3： | 1 |
| 20 | Mn Partitioning during the intercritical annealing of ultrafine- grained 6% Mn transformation-induced plasticity steel 显示文摘 | Seok-jae lee Seawoong lee Bruno C De cooman | 2010 | Scripta Materialia2010，64，7： | 1 |
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