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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Family 6 carbohydrate binding modules recognize the non-reducing end of beta-1,3-1inked glucans by presenting a unique ligand binding surface显示文摘 | van Bueren AL Morland C Gilbert HJ | 2005 | Journal of Biological Chemistry2005，280，1： | 1 |
| 3 | Large cell/ anaplastic medulloblastoma:outcome according to myc status,histopathological,and clinical risk factors显示文摘 | von Hoff K Hartmann W von Bueren AO | 2010 | Pediatr Blood Cancer2010，54，3： | 1 |
| 4 | Treatment of young children with CNS-primitive neuroecto- dermal tumors/pineoblastomas in the prospective multi- center trial HIT 2000 using different chemotherapy regi- mens and radiotherapy显示文摘 | FRIEDRICH C VON BUEREN AO VON HOFF K | 2013 | Neuro oneo12013，15，2： | 1 |
| 5 | The PCNA- associated factor KIAA0101/p15 (PAF) binds the potential tumor suppressor product p331NGlb显示文摘 | Simpson F van Bueren KL Butterfield N | 2006 | Exp Cell Res2006，312，1： | 1 |
| 6 | Latent hematopoietic stem cell toxicity associated with protracted drug adminstration 显示文摘 | Keyes KA Segovia JC Bueren JA | 2001 | Exp Hematol2001，29，3： | 1 |
| 7 | Complementmediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor(EGFR)and its variantⅢ(EGFRvⅢ)显示文摘 | Klausz K Berqer S Lammerts van Bueren JJ | 2011 | Cancer Sci2011，102，10： | 1 |
| 8 | Forebrain ischemia increases Glutl protein in brain microvessels and parenchyma 显示文摘 | McCall AL Van Bueren AM Nipper V | 1996 | J Cereb Blood Flow Metab1996，16，1： | 1 |
| 9 | c-MYC expression sensitizes medulloblastoma ceils to radio- and chemotherapy and has no impact on response in medulloblastoma patients 显示文摘 | Von Bueren AO Oehler C Shalaby T | 2011 | BMC Cancer2011，11，： | 1 |
| 10 | Large cell/anaplastic medulloblastoma : outcome according to myc status,histopathological,and clinical risk factors 显示文摘 | von Hoff K Hartmann W von Bueren AO | 2010 | Pediatric BloodCancer2010，54，3： | 1 |
| 11 | Improving performance of customer processes with knowledge management 显示文摘 | Bueren Adrian Schierholz Ragnar Lutz M Kolbe WalterBrenner | 2005 | Business Process Management Journal2005，，11： | 1 |
| 12 | Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor(EGFR)and its variant III(EGFRvIII)显示文摘 | Klausz K Berger S Lammerts van Bueren JJ | 2011 | Cancer Sci2011，102，： | 1 |
| 13 | Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/ macrophage (CFU-GM) assay显示文摘 | Pessinaa A Albella B Bueren J | 2001 | Toxicology in Vitro2001，15，72： | 1 |
| 14 | Interferon-gammamediated up-regulation of caspase-8 sensitizes medulloblastomacells to radio- and chemotherapy显示文摘 | Meister N Shalaby T von Bueren AO | 2007 | Eur J Cancer2007，43，12： | 1 |
| 15 | CD38-targeted immunochemotherapy of multiple myeloma: preclinical evidence for its combinatorial use in lenalidomide and borlezomib refractory/intolerant MM patients显示文摘 | Nijhof IS Noort WA Bueren JLV | 2013 | Blood (ASH Annual Meeting Abstracts)2013，122，： | 1 |
| 16 | Improving performance of customer-processes with knowledge management显示文摘 | Adrian Bueren Ragnar Schierholz Lutz M. Kolbe Walter Brenner | 2005 | Business Process Management Journal2005，，5： | 1 |
| 17 | Novel human antibody therapeutics: the age of the Umabs 显示文摘 | Ruuls SR Lammerts van Bueren JJ van de Winkel JG | 2008 | Biotechnol J2008，3，： | 1 |
| 18 | The structural basis of substrate recognition in an exo-:-D- glucosaminidase involved in chitosan hydrolysis 显示文摘 | van Bueren A L Ghinet M G Gregg K | 2009 | Mol Biol2009，385，1： | 1 |
| 19 | Treatment ofadult nonmetastatic medulloblastoma patients according to thepaediatric HIT 2000 protocol : a prospective observationalmulticentre study显示文摘 | Friedrich C von Bueren AO von Hoff K | 2013 | Eur J Cancer2013，49，4： | 1 |
| 20 | Treatment ofyoung children with localized medulloblastoma by chemotherapyalone: results of the prospective,multicenter trial HIT 2000confirming the prognostic impact of histology 显示文摘 | von Bueren AO von Hoff K Pietsch T | 2011 | Neuro Oncol2011，13，6： | 1 |
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