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| 1 | New perspectives on probiotics in health and disease显示文摘The gut microbiota continues to fascinate scientists in many realms when it is considered that humans contain 90%bacteria.Correlations between changes in composition and activity of the gut microbiota and common disorders such as cancer,hypertension,hypercholesterolemia,inflammatory bowel diseases,obesity,oral health,etc.have been proposed.What is the real role of probiotics,prebiotics and synbiotics in influencing a healthy microbiota?Both in vitro evidences and in vivo clinical data have supported some of these new health claims,while recent molecular advancement has provided strong indications to support and justify the hypotheses.However,probiotics validity and health claims have continuously been rejected on the basis of“biomarker deficiency”.To battle the increase in health care costs,a preventive approach to medicine with the development of probiotics and prebiotics or symbiotic products is being advanced.This review discusses the potential beneficial effects of probiotics in preventing and treating certain diseases as well as current and future perspectives of probiotic research. | Eric Banan-Mwine Daliri Byong H.Lee | 2015 | Food Science and Human Wellness2015，4，2： | 4 |
| 2 | Clinical course of ulcerative colitis patients who develop acute pancreatitis显示文摘AIM To investigate the clinical course of ulcerative colitis(UC)patients who develop acute pancreatitis.METHODS We analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015.The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC patients.RESULTS Among 51 patients who developed acute pancreatitis,13(0.40%)had autoimmune,10(0.30%)had aminosalicylate-induced,and 13(1.73%)had thiopurineinduced pancreatitis.All 13 patients with autoimmune pancreatitis(AIP)had type 2 AIP.Two(15.4%)patients had pre-existing AIP,and three(23.1%)patients developed AIP and UC simultaneously.Compared to non-pancreatitis patients,AIP patients had UC diagnosed at a significantly younger age(median,22.9 years vs 36.4 years;P=0.001).AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients.All patients with pancreatitis recovered uneventfully,and there were no recurrences.Biologics were used more frequently in aminosalicylate-and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients[adjusted OR(95%CI),5.16(1.42-18.67)and6.90(1.83-25.98),respectively].Biologic utilization rate was similar among AIP and non-pancreatitis patients[OR(95%CI),0.84(0.11-6.66)].Colectomy rates for autoimmune,aminosalicylate-induced,and thiopurineinduced pancreatitis,and for non-pancreatitis patients were 15.4%(2/13),20%(2/10),15.4%(2/13),and7.3%(239/3256),respectively;the rates were not significantly different after adjusting for baseline disease extent.CONCLUSION Pancreatitis patients show a non-significant increase in colectomy,after adjusting for baseline disease extent. | Jong Wook Kim Sung Wook Hwang Sang Hyoung Park Tae Jun Song Myung-Hwan Kim Ho-Su Lee Byong Duk Ye Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang | 2017 | World Journal of Gastroenterology2017，23，19： | 3 |
| 3 | Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis显示文摘AIM To investigate the temporal trends in the misdiagnosis rate between Crohn's disease(CD) and intestinal tuberculosis(ITB) in South Korea. METHODS We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB(final CD group) and vice versa(final ITB group). Final diagnostic criteria for ITB and medication for CD before definite diagnosis of TB were also analyzed in final ITB group.RESULTS In total, 2760 patients were managed for CD and 772 patients for ITB between 1996 and 2014. As well, 494 of the 2760 CD patients(17.9%) were initially misdiagnosed as ITB and 83 of the 772 ITB patients(10.8%) as CD. The temporal trend in misdiagnosing CD as ITB showed a decrease(OR = 0.89, 95%CI: 0.87-0.91, P < 0.001), whereas the temporal trend in misdiagnosing ITB as CD showed an increase(OR = 1.06, 95%CI: 1.01-1.11, P = 0.013). Age at diagnosis, presenting symptoms, and proportion of patients with active/past perianal fistula and active/inactive pulmonary tuberculosis(TB) were significantly different between final CD group and final ITB group. Forty patients(48.2%) in final ITB group were diagnosed by favorable response to empirical anti-TB treatment. Seventeen patients(20.5%) in final ITB group had inappropriately received corticosteroids and/or thiopurines due to misdiagnosis as CD. However, there were no mortalities in both groups. CONCLUSION Cases of CD misdiagnosed as ITB have been decreasing, whereas cases of ITB misdiagnosed as CD have been increasing over the past two decades. | Hyungil Seo Seohyun Lee Hoonsub So Donghoi Kim Seon-Ok Kim Jae Seung Soh Jung Ho Bae Sun-Ho Lee Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Byong Duk Ye | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 4 | Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease显示文摘AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) patients.METHODS This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 mo.RESULTS During the follow-up period, 66 patients(25.4%) underwent a second operation for disease recurrence.At 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence. | Kwan Mo Yang Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Sang Hyoung Park Byong Duk Ye Suk-Kyun Yang Jin Cheon Kim | 2017 | World Journal of Gastroenterology2017，23，38： | 3 |
| 5 | The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer显示文摘 | Chang Moo Kang Jun Young Kim Gi Hong Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee Byong Ro Kim | 2007 | Journal of Surgical Research2007，，： | 3 |
| 6 | Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma显示文摘 | Jeong Won Jang Byong Sun Oh Jung Hyun Kwon Chan Ran You Kyu Won Chung Chul Seung Kay Hyun Suk Jung | 2012 | Cytokine2012，，3： | 2 |
| 7 | Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis显示文摘 | Yang Min Jin Kim Seong Jeon Yoon Jeen Jong Im Dae Cheung Myung-Gyu Choi Jin-Oh Kim Kwang Lee Byong Ye Ki-Nam Shim Jeong Moon Ji Kim Sung Hong Dong Chang | 2013 | Endoscopy2013，，： | 2 |
| 8 | Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn's disease显示文摘AIM To investigate the clinical implications of infliximab trough levels(IFX-TLs) and antibodies to infliximab(ATI) levels in Crohn's disease(CD) patients in Asian countries. METHODS IFX-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD(quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician's judgment of patients' clinical status at enrollment. The impact of concomitant immunomodulators was also investigated. RESULTS This study enrolled 138 patients with CD(84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively(P < 0.001) and the median ATI levels were 8.064 AU/m L and 11.209 AU/m L, respectively(P < 0.001). In the ATI-negative and-positive groups, the median IFXTLs were 1.415 μg/mL and 0.141 μg/mL, respectively(P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs(0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels(8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083).CONCLUSION IFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice. | Eun Hye Oh Dae-Hyun Ko Hyungil Seo Kiju Chang Gwang-Un Kim Eun Mi Song Myeongsook Seo Ho-Su Lee Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park | 2017 | World Journal of Gastroenterology2017，23，8： | 2 |
| 9 | Specifieity,inhibitory, studies and oligoaseeharide fomartoin by :-Galacotsidaes form psychrotorphie Bacillus subtilis KL88显示文摘 | Khalid A A Rahim Byong H L | 1991 | J Dairy Sci1991，74，： | 1 |
| 10 | The Effect of Soft Re duction on Center Segregation in CC Slab显示文摘 | Chang H Y Joong K P Byong D Y | 1996 | IS1J International1996，，： | 1 |
| 11 | Effect of deink- ing agent wettability on the alkaline deinking of mixed office waste paper 显示文摘 | Yoon Byong Tae Kim Young-Ho Kim Chul-Ung | 2003 | Journal of Korea Technical Association2003，35，4： | 1 |
| 12 | Preparation and evaluation of the chitin derivatives for wastewater treatments显示文摘 | Aly Sayed Aly Byong Dae Jeon Yun Heum Park | 1997 | Jourmal of Applied Polymer Science1997，65，10： | 1 |
| 13 | Fast simulated annealing inversion of surface waves on pavement using phase-velocity spectra显示文摘 | Nils Ryden Choon Byong Park | 2006 | Geophysics2006，71，4： | 1 |
| 14 | Flexural behavior of reinforced concrete beams strengthened with CFRP sheets and epoxy mortar显示文摘 | Byong Y Bahnl Ronald S | 2008 | Journal of Composites for Construction ASCE2008，12，4： | 1 |
| 15 | Capsule endoscopy in small bowel tumors: A multicenter Korean study显示文摘 | Dae YoungCheung In‐SeokLee Dong KyungChang Jin OhKim Jae HeeCheon Byung IkJang Yong‐SikKim Cheol HeePark Kwang JaeLee Ki‐NamShim Ji‐KonRyu Jae‐HyukDo Jeong‐SeopMoon Byong DukYe Kyung‐JoKim Yun JeongLim Myung‐GyuChoi Hoon‐JaiChun | 2010 | Journal of Gastroenterology and Hepatology2010，，6： | 1 |
| 16 | Thermal hydraulic performance analysis of the printed circuit heat exchanger using a helium test facility and CFD simulations显示文摘 | In Hun Kim Hee Cheon No Jeong Ik Lee Byong Guk Jeon | 2009 | Nuclear Engineering and Design2009，，11： | 1 |
| 17 | The Effectiveness of Price Limits in an Emerging Market: Evidence from the Korean Stock Exchange显示文摘 | Henk Berkman John Byong Tek Lee | 2002 | Pacific-Basin Finance Journal2002，，10： | 1 |
| 18 | Clinical outcomes of rectal neuroendocrine tumors ≤ 10 mm following endoscopic resection显示文摘 | Gwang-Un Kim Kyung-Jo Kim Seung-Mo Hong Eun-Sil Yu Dong-Hoon Yang Kee Jung Byong Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Jin-Ho Kim | 2013 | Endoscopy2013，，12： | 1 |
| 19 | Political Efficacy and Trust in Rural South Korea显示文摘 | AHN BYONG MANand BOYER WILLIAM W | 1986 | The Journal of Developing Areas1986，，4： | 1 |
| 20 | Risk factors and outcome of acute severe lower gastrointestinal bleeding in Crohn’s disease显示文摘 | Kyung-Jo Kim Bong Jun Han Suk-Kyun Yang Soo Young Na Soo-Kyung Park Sun-Jin Boo Sang Hyoung Park Dong-Hoon Yang Jae Ho Park Kee Wook Jeong Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Jin-Ho Kim | 2012 | Digestive and Liver Disease2012，，9： | 1 |
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