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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 开放手术和经皮螺钉2种内固定方式联合外侧腰椎间融合术(LLIF)治疗成人退变性脊柱侧弯的效果比较显示文摘成人退变性脊柱侧弯(adultdegenerativescoliosis,ADS)老年人常见,50岁以上人群发病率约为6%。采用椎间融合术治疗ADS可获得有效椎间融合,同时纠正畸形。 | Attenello J Chang C Lee YP 陈恩良 吴增晖 | 2018 | 中国骨科临床与基础研究杂志2018，10，3： | 14 |
| 3 | Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease显示文摘 | Feng Z Qin C Chang Y Zhang JT | 2006 | 中国生物学文摘2006，20，10： | 13 |
| 4 | 武夷山脉南北蕨类植物生物多样性研究显示文摘从植物区系、生物多样性容量、通量和质量等方面比较了武夷山脉从南到北梁野山、闽江源、武夷山3个国家级自然保护区中蕨类植物的生物多样性.结果表明,在武夷山脉由南到北,蕨类植物的热带性成分趋于递减,北温带分布及其变型、东亚分布及其变型递增.由物种数及丰富度指数DGl可以得出,武夷山自然保护区蕨类植物生物多样性容量最大.连通性方面,武夷山脉不同的保护区间物种水平的相似性不到55%,而从武夷山脉南段至中段、中段至北段,种的β多样性指数βL值都达到30%,这两点说明武夷山脉是蕨类植物的现代分化中心之一.通过考察Cody指数βC发现,中段的闽江源自然保护区是武夷山脉的重要节点.虽然流通率表明武夷山脉蕨类植物的连通性较强,但在物种水平上,更替值在南段到中段、中段到北段均超过30%,因此有必要进一步在保护区之间建立与建设供动植物物种迁移的生态廊道.由于保存了较多的蕨类植物模式标本种和局域种,在充分考虑物种权值的前提下,武夷山自然保护区的蕨类植物生物多样性质量指数值达764,因此其多样性质量最高.研究结果可以为保护区群网的建设提供理论依据. | 叶文 李振基 BENITO C Tan CHANG Ying 陈鹭真 何建源 刘初钿 | 2007 | 厦门大学学报(自然科学版)2007，46，3： | 9 |
| 5 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 6 | 胞质异质性——人类肿瘤组织线粒体基因突变的普遍现象显示文摘为了探讨不同肿瘤组织中线粒体基因体细胞性突变的胞质异质性和同质性状态,利用32对重叠引物对149例肿瘤组织和匹配正常组织的全线粒体基因进行PCR扩增,并同时进行时相温度梯度凝胶电泳扫描突变筛选,基因测序确定突变类型与异质状况。结果表明,不同肿瘤组织中线粒体基因体细胞性突变的异质率不同,口腔癌(65%)和食道癌(64%)具有较高的异质率,其次为乳腺癌(45 9%)。4种转换形式的发生频率以Hm→Hm>Hm→Ht>Ht→Hm>Ht→Ht为主。碱基转换的主要转换形式为Hm→Hm,碱基颠换则以Hm→Ht为主。认为胞质异质性是人类肿瘤组织线粒体基因突变的普遍现象。 | 谭端军 刘玲玲 文毅 刘鹏 Julia Chang Kun-Tu Yeh Lee Jun C Wong | 2005 | 遗传2005，27，1： | 5 |
| 7 | 人类肿瘤组织线粒体基因D310区域的单核苷酸重复序列变异显示文摘目的 :拟对线粒体基因D环区的一个特异和高度多态性的D3 10多聚C区域的变异情况进行评估。方法 :对 14 9例肿瘤组织和匹配的正常组织的线粒体基因D环区进行PCR扩增 ,并同时进行时相温度梯度凝胶电泳扫描和D3 10区域的序列测定。结果 :43个 (2 8 86% )肿瘤具有D3 10单核苷酸重复区的体细胞性插入或缺失突变 ,其中绝大部分为 1 2bp插入或缺失 ,与以前报道的该区域多态性变化一致。约 3 4 9%肿瘤组织中的突变为同质状态 ,65 1%处于异质状态。结论 :线粒体基因D3 10单核苷酸重复区变异在人类肿瘤组织中是一个常见的现象。 | 谭端军 刘玲玲 卢才义 刘鹏 Julia Chang Kun-Tu Yeh LeeJun C Wong | 2003 | 实用医学杂志2003，19，11： | 4 |
| 8 | A new true triaxial cell for testing mechanical properties of rock, and its use to determine rock strength and deformability of Westerly granite显示文摘 | B Haimson C Chang | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，，1： | 4 |
| 9 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 10 | New universal current-mode filter with single input and three output using only five current conveyors显示文摘 | Chang C M | 1993 | Eletronics letters1993，29，： | 3 |
| 11 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 12 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 13 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 14 | Densities and P-x-y diagrams for carbo dioxide dissolution in methanol,ethano, and acetone mixtures显示文摘 | Chang C J Day C Y Ko C M | 1997 | Fluid Phase Equilib1997，131，： | 2 |
| 15 | Drained,undrained,consolidating and dynamic behaviour assumptions in solis; Limits of validity 显示文摘 | Zienkiewicz O C Chang C T Bettess P | 1980 | Geotechnique1980，30，： | 2 |
| 16 | Expandion of Philadephia chromosome-negative CD3+CD56+cytotoxic cells from chronic myeloid leukaemia patients:in vitro and in vivo efficacy in severe combined immunodeficiency disease mice显示文摘 | Hoyle C Bangs CD Chang P | 1998 | Blood1998，92，9： | 2 |
| 17 | 早产儿出生时气管内吸出物中的白介素-6含量增加是随后支气管肺发育不良的预测因子显示文摘Aim:We tested whether interleukin-6(IL-6)in tracheal aspirate(TA)at birth,as a marker of fetal pulmonary inflammation,can be a predictor of bronchopulmonary dysplasia(BPD)in preterm infants.Methods:A total of 75 preterm(≤32 wk)infants who were intubated in the delivery room were prospectively enrolled.Multivariate logistic regression analysis was done to determine whether IL-6 in TA at birth is an independent risk factor for BPD,and a receiver-operating characteristic curve was constructed to determine the accuracy of IL-6 in TA for predicting the risk of BPD.Results:IL-6 in TA at birth was an independent risk factor for BPD.Fetal pulmonary inflammation defined as IL-6 in TA at birth ≥316 pg/ml together with patent ductus arteriosus(PDA)additively predicted the risk of BPD.The sensitivity,specificity,and positive and negative predictive values of fetal pulmonary inflammation for the identification of BPD were 73%,71%,58%and 83%,respectively.Conclusion:IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA. | Chang W. C Kim B. I Kim H. - S 郭战宏(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 2 |
| 18 | Wide diameter of butterfly networks 显示文摘 | LIAW S C CHANG G J | 1999 | Taiwanese Journal of Mathematics1999，3，： | 2 |
| 19 | Rabin numbers of butterfly networks 显示文摘 | LIAW S C CHANG G J | 1999 | Discrete Mathematics1999，196，： | 2 |
| 20 | Generalized diameters and Rabin numbers of networks 显示文摘 | LIAW S C CHANG G J | 1999 | Journal of Combinatorial Optimization1999，4，： | 2 |
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