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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 3 | Trends of Extreme Precipitation in Eastern China and Their Possible Causes显示文摘Significant increases of heavy precipitation and decreases of light precipitation have been reported over widespread regions of the globe. Global warming and effects of anthropogenic aerosols have both been proposed as possible causes of these changes. We examine data from urban and rural meteorological stations in eastern China(1955–2011) and compare them with Global Precipitation Climatology Project(GPCP) data(1979–2007) and reanalysis data in various latitude zones to study changes in precipitation extremes. Significant decreases in light precipitation and increases in heavy precipitation are found at both rural and urban stations, as well as low latitudes over the ocean, while total precipitation shows little change.Characteristics of these changes and changes in the equatorial zone and other latitudes suggest that global warming rather than aerosol effects is the primary cause of the changes. In eastern China, increases of annual total dry days(28 days) and 10 consecutive dry days(36%) are due to the decrease in light precipitation days, thereby establishing a causal link among global warming, changes in precipitation extremes, and higher meteorological risk of floods and droughts. Further, results derived from the GPCP data and reanalysis data suggest that the causal link exists over widespread regions of the globe. | LIU Run LIU Shaw Chen Ralph J.CICERONE SHIU Chein-Jung LI Jun WANG Jingli ZHANG Yuanhang | 2015 | Advances in Atmospheric Sciences2015，32，8： | 19 |
| 4 | 帕博利珠单抗(pembrolizumab)与化疗治疗微卫星不稳定性高/错配修复缺陷型转移性结直肠癌的比较:KEYNOTE-177的3期研究显示文摘背景:KEYNOTE-177 (NCT02563002)是一项3期随机、开放标签的临床研究,评估了帕博利珠单抗与标准化疗±贝伐珠单抗或西妥昔单抗作为微卫星不稳定性高/错配修复缺陷(MSI-H/d MMR)型转移性结直肠癌患者一线治疗的效果和安全性。本次公布了终期PFS分析的结果。方法:共有307名由当地医疗机构评判的MSI-H/d MMR且ECOG PS评分为0或1的转移性结直肠癌患者按1:1比例随机分组接受治疗,治疗方案为一线帕博利珠单抗(200 mg,Q3W,最长治疗时限为2年),或为研究者所选择的化疗方案,包括m FOLFOX6或FOLFIRI Q2W±贝伐珠单抗或西妥昔单抗(随机选择化疗方案)。治疗终止于出现PD、无法耐受的毒性、患者/研究者决定退出治疗或完成35个周期治疗(仅对于帕博利珠单抗而言)。确诊PD后,接受化疗组患者可转入帕博利珠单抗组并接受最长为35个周期的治疗。主要终点是PFS (RECIST v1.1,中心审查)和OS。主要的次要终点包括ORR (RECIST v1.1,中心审查)和安全性。该中期分析的数据截止日期是2020年2月19日。该研究仍将继续随访评估OS。结果:截止数据纳入时,153名患者被随机分至帕博利珠单抗组,154名患者被随机分至化疗组。帕博利珠单抗组的中位随访为28.4个月(0.2~48.3个月),化疗组为27.2个月(0.8~46.6个月)。帕博利珠单抗组PFS优于化疗组(中位时间16.5个月vs. 8.2个月;HR=0.60,95%CI:0.45~0.80,P=0.0002)。帕博利珠单抗组的12个月和24个月PFS率分别为55.3%和48.3%,化疗组则相应分别为37.3%和18.6%。帕博利珠单抗组与化疗组经确认的ORR分别为43.8%与33.1%;帕博利珠单抗组与化疗组中位持续反应时间分别为未达到(2.3+~41.4+个月)和10.6个月(2.8~37.5+个月)。帕博利珠单抗组3~5级与治疗相关的不良事件(AE)发生率为22%,化疗组为66%。化疗组中有1例患者因治疗相关的AE死亡。结论:与化疗相比,帕博利珠单抗作为MSI-H/d MMR型转移性结直肠癌的一线治疗可提供具有临床意义和统计学意义的PFS获益,同时观察到较少的与治疗相关的AE,应该成为这类患者的新的标准治疗方案。 | 陈功 ANDRé T SHIU K K KIM T W | 2020 | 结直肠肛门外科2020，26，6： | 15 |
| 5 | Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells显示文摘AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cay pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro.METHODS: A cytotoxic wild-type H pylori strain (TN2),its three isogenic mutants (TN2△cag, TN2△cagA and TN2△cagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45,were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter.RESULTS: The wild-type strain and the isogenic mutants,TN2△cagA and TN2△cagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2△cag did not increase the release of MIF at any of the four ratios.3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2△cagA and TN2△cagE, but not from the mutant TN2△cag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared.CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric epithelial cell proliferation. | Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong | 2005 | World Journal of Gastroenterology2005，11，13： | 12 |
| 6 | 幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受显示文摘目的 建立幽门螺杆菌 (Hp)慢性感染胃上皮细胞模型 ,并分析Hp慢性感染与胃上皮细胞凋亡的关系。方法 用HpSS1与人非肿瘤性胃上皮细胞株GES 1共培养 16周 ,建立GES 1模型细胞 ,然后采用流式细胞术分析这种模型细胞对Hp和其它肠道细菌以及抗肿瘤药物凋亡诱导剂的应答。结果 成功获得了Hp慢性感染胃上皮细胞模型 (GES 1模型细胞 )。这种模型细胞不仅对Hp诱导的凋亡耐受 ,而且对其他肠道细菌和一些凋亡诱导剂也是耐受的。结论 幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受 ,由此可能增加了胃上皮细胞癌变的危险性。 | 何兴祥 胡品津 Benjamin Chun Yu Wong Shiu Kum Lam Harry Hua Xiang Xia | 2003 | 中华医学杂志2003，83，1： | 6 |
| 7 | L(j,k)-number of Direct Product of Path and Cycle显示文摘For positive numbers j and k, an L(j,k)-labeling f of G is an assignment of numbers to vertices of G such that |f(u)-f(v)|≥j if uv∈E(G), and |f(u)-f(v)|≥k if d(u,v)=2. Then the span of f is the difference between the maximum and the minimum numbers assigned by f. The L(j,k)-number of G, denoted by λj,k(G), is the minimum span over all L(j,k)-labelings of G. In this paper, we give some results about the L(j,k)-number of the direct product of a path and a cycle for j≤k. | Wai Chee SHIU Qiong WU | 2013 | Acta Mathematica Sinica,English Series2013，29，8： | 6 |
| 8 | Super-edge-graceful Labelings of Some Cubic Graphs显示文摘The notion of super-edge-graceful graphs was introduced by Mitchem and Simoson in 1994.However,few examples except trees are known.In this paper,we exhibit two classes of infinitely manycubic graphs which are super-edge-graceful.A conjecture is proposed. | Wai Chee SHIU | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 5 |
| 9 | A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population显示文摘AIM: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment.METHODS: This was a retrospective cross-sectional study.Fifty-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of life.Noncompliance was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the consultation.Relationships between noncompliance and demographics,attitude,disease and treatment status was studied.Cost was estimated with quality of life and direct medical cost involved with noncompliance.Multivariable logistic regression on noncompliance was performed on selected factors.RESULTS: Compliance was calculated as 75%(95% CI: 64%-87%) among 57 subjects(mean age 69 y,female 51%).No statistical significant relationship was established between noncompliance and any single factors or outcomes.Age(P=0.048) and forgetfulness(P=0.064) were found to be marginally significant predictive factors on noncompliance in multivariable logistic regression.Noncompliance might be related(P=0.130) to poorer self-rated vision-associated quality of life.The societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million territory-wide.CONCLUSION: The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal levels.Age and forgetfulness are two possible independent predictors for noncompliance. | Man-Hin Lui Jason Chun Ho Lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu Lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 5 |
| 10 | Ⅱ型糖尿病患者人生取向与压力感受的相关性研究显示文摘目的 探讨人生取向(SOC)水平和压力感受水平之间的相关性。方法 采用压力感受量 表和SOC-13(人生取向)量表,以目的抽样,对220名Ⅱ型糖尿病成人患者,采取无记名自评方式进行 横断面调查。结果 人生取向平均得分(63±13.9)分,居于中等水平;压力感受总分平均74.7分,在中 度以下;Ⅱ型糖尿病患者的压力感受与SOC分值呈负相关(r=-0.404,P<0.001)。结论 Ⅱ型糖尿 病患者的压力感受与SOC分值呈负相关,表示SOC分值越高,糖尿病患者的压力感受水平越低,说明 提高Ⅱ型糖尿病患者的SOC水平,可以减轻患者的压力感受程度。 | 何彩云 袁爱华 严谨 林德群 Ann Tak-Ying Shiu | 2005 | 现代护理2005，11，3： | 5 |
| 11 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 12 | Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing显示文摘OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture healing.METHODS:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was prepared.The rats were treated with either CDR topically on the fracture site,or Sr R orally,or their combinations.Bone turnover biochemical markers in serum were measured.Microarchitecture of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical analysis.RESULTS:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of treatment.This result was consistent with the histomorphometrical analysis on the osteoid volume.Analysis of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after fracture.CONCLUSION:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption. | Siu Wing Sum Shiu Hoi Ting Shum Wai Ting Ko Chun Hay Lau Clara Bik San Hung Leung Kim Leung Ping Chung | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 4 |
| 13 | On the adjacent vertex-distinguishing acyclic edge coloring of some graphs显示文摘A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v,where uv ∈ E(G).The adjacent vertex distinguishing acyclic edge chromatic number of G,denoted by χAa(G),is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G.If a graph G has an adjacent vertex distinguishing acyclic edge coloring,then G is called adjacent vertex distinguishing acyclic.In this paper,we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures. | SHIU Wai Chee CHAN Wai Hong ZHANG Zhong-fu BIAN Liang | 2011 | Applied Mathematics(A Journal of Chinese Universities)2011，26，4： | 3 |
| 14 | Graphs Whose Critical Groups Have Larger Rank显示文摘图 G 的批评的组 C (G) 是跨越图的树的数字的精炼并且仔细与拉普拉斯算符矩阵被连接。让 r (G) 是发电机的最小的数字(即,等级) 组 C,(G) 和(G) 是 G 的独立周期的数字。在这份报纸,某禁止的导致的 subgraphs 为 r (G)= n 被给 3 并且有 r (G)=(G)= n 的所有图 3 被描绘。 | Yao Ping HOU Wai Chee SHIU Wai Hong CHAN | 2011 | Acta Mathematica Sinica,English Series2011，27，9： | 3 |
| 15 | Trends of Regional Precipitation and Their Control Mechanisms during 1979–2013显示文摘Trends in precipitation are critical to water resources. Considerable uncertainty remains concerning the trends of regional precipitation in response to global warming and their controlling mechanisms. Here, we use an interannual difference method to derive trends of regional precipitation from GPCP(Global Precipitation Climatology Project) data and MERRA(ModernEra Retrospective Analysis for Research and Applications) reanalysis in the near-global domain of 60?S–60?N during a major global warming period of 1979–2013. We find that trends of regional annual precipitation are primarily driven by changes in the top 30% heavy precipitation events, which in turn are controlled by changes in precipitable water in response to global warming, i.e., by thermodynamic processes. Significant drying trends are found in most parts of the U.S. and eastern Canada,the Middle East, and eastern South America, while significant increases in precipitation occur in northern Australia, southern Africa, western India and western China. In addition, as the climate warms there are extensive enhancements and expansions of the three major tropical precipitation centers–the Maritime Continent, Central America, and tropical Africa–leading to the observed widening of Hadley cells and a significant strengthening of the global hydrological cycle. | Run LIU Shaw Chen LIU Chein-Jung SHIU Jun LI Yuanhang ZHANG | 2016 | Advances in Atmospheric Sciences2016，33，2： | 3 |
| 16 | Inhibition of malignant trophoblastic cell proliferation in vitro and in vivo by melatonin显示文摘 | Shiu SY Xi SC Xu JN | 2000 | Life Sci2000，67，17： | 2 |
| 17 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 18 | Service worker role in encouraging customer organizational citizenship behaviors显示文摘 | Liliana L. Bove Simon J. Pervan Sharon E. Beatty Edward Shiu | 2008 | Journal of Business Research2008，，7： | 2 |
| 19 | Transferring case knowledge to adaptation knowledge: an approach for case-base maintenance显示文摘 | Shiu S C K | 2001 | Computational Intelligence2001，17，2： | 2 |
| 20 | Full Friendly Index Sets of Cartesian Products of Two Cycles显示文摘让 G =(V, E ) 是一张连接的简单的图。标记的 f:V 鈫 ?? 2 导致把 f 标记的一个边 * :E 鈫 ?? 2 由 f 定义 *(xy ) 为每 xy 鈭 ? E 的 = f (x)+ f (y) 。为 i 鈭 ?? 2,让的蠀 f (i)=| f ? 1 (i)|并且 e f (i)=| f *? 1 (i)| 。标记的 f 被叫友好如果 | 蠀 f (1 ) 吗?蠀 f (0 )|鈮 ? 1。为图 G 的友好标记 f,我们由 i f (G)= e f (1 ) 在 f 下面定义 G 的友好索引吗?ef(0) 。集合 { i f (G)|f 是 G 的一个友好标记 } 被称为 G 的完整的友好索引集合,由 FFI (G) 表示了。在这份报纸,我们将决定二个周期的每个笛卡儿的产品的完整的友好索引集合。标记的关键词顶点 - 友好标记 - 友好索引集合 - 二周期先生(2000 ) 题目分类 05C78 的笛卡儿的产品 - FRG/07-08/II-55 香港支持的 05C25 | Wai chee SHIU | 2010 | Acta Mathematica Sinica,English Series2010，26，7： | 2 |
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