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| 1 | Virologic factors associated with failure to passive–active immunoprophylaxis in infants born to HBsAg‐positive mothers显示文摘 | H.Zou Y.Chen Z.Duan H.Zhang C.Pan | 2012 | Journal of Viral Hepatitis2012，，2： | 2 |
| 2 | Technical review on Chinese digital terrestrial television broadcasting standard and measurements on some working modes显示文摘 | J.Song Z.Yang L.Yang K.Gong C.Pan J.Wang and Y.Wu | | 0，，01： | 1 |
| 3 | Plasma-Jet Forming of Sheet Metal Shapes显示文摘Plasma-jet forming is a newly proposed flexible sheet metal forming process. A non-transferred arc plasma torch is used as a controllable heat source to produce internal stress in sheet metals, causing plastic deformation without the necessity of hard tooling. This method has potential for rapid prototyping of sheet metal parts by reducing development costs and lead times. A robotic system has been used to perform simple linear bends in several different alloys. In order to develop a controllable process and to improve the forming accuracy, the effects of various process parameters on the obtained shape changes and on the resulting structure and properties have been studied. The overall goal is to understand the roles of the forming parameters and their inter-relationship in optimizing the forming procedure-a high forming speed without damage to the material structure or properties. | A.T.Male Y.W.Chen P.J.Li C.Pan and Y.M.Zhang Center for Robottes and Manufacturing Systems, University of Kentucky, Lexington, KY 40506-0108, USA | 2001 | Journal of Materials Science & Technology2001，17，1： | 1 |
| 4 | Correlating dynamic characteristics from field measurements and numerical analysis of a high‐rise building显示文摘 | J. M. W.Brownjohn T. C.Pan X. Y.Deng | 2000 | Earthquake Engng Struct Dyn2000，，4： | 1 |
| 5 | Virologic factors associated with failure to passive–active immunoprophylaxis in infants born to HBsAg‐positive mothers显示文摘 | H.Zou Y.Chen Z.Duan H.Zhang C.Pan | 2012 | Journal of Viral Hepatitis2012，，2： | 1 |
| 6 | Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing显示文摘Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental molecular pathways driving senescence instead of apoptosis could enable the identification of senolytic agents to restore tissue homeostasis.Here,we identify thrombomodulin(THBD)signaling as a key molecular determinant of the senescent cell fate.Although normally restricted to endothelial cells,THBD is rapidly upregulated and maintained throughout all phases of the senescence program in aged mammalian tissues and in senescent cell models.Mechanistically,THBD activates a proteolytic feed-forward signaling pathway by stabilizing a multi-protein complex in early endosomes,thus forming a molecular basis for the irreversibility of the senescence program and ensuring senescent cell viability.Therapeutically,THBD signaling depletion or inhibition using vorapaxar,an FDA-approved drug,effectively ablates senescent cells and restores tissue homeostasis in liver fibrosis models.Collectively,these results uncover proteolytic THBD signaling as a conserved pro-survival pathway essential for senescent cell viability,thus providing a pharmacologically exploitable senolytic target for senescence-associated diseases. | Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang | 2023 | Cell Research2023，33，7： | 0 |
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