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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | 利用洋底地震资料估算进入马里亚纳俯冲带的水通量显示文摘俯冲带水迁移是地表水进入地球深部的主要方式。但是,通过板块俯冲到底能够带入深部地幔多少水受到多种因素影响,包括俯冲带板片年龄、俯冲带几何性质、俯冲带热结构、板块汇聚速率等。目前关于俯;中带的水循环仍知之甚少。最近,华盛顿大学地球与行星科学系的Cai C博士等人收集和分析了马里亚纳海沟中心周围宽频洋底瑞利面波地震数据,估算了通过板块俯冲输入地球深部的水通量。他们的研究结果表明:板块俯冲带入深部地幔的水通量是以前估算的4.3倍,而且远大于目前对地幔输出水通量的估计。由于大量的长期净水流入地球深处与地质记录中的海平面稳定性不一致;同时也没有迹象表明马里亚纳俯冲带的板块弯曲区在形态和断裂强度与其它古俯冲带的对应区域对比有很大的不同。 | Cai C Wiens D A Shen W Eimer M 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 13 |
| 3 | Generalized crack initiation and crack damage stress thresholds of brittle rock masses near underground excavations显示文摘 | M Cai P.K Kaiser Y Tasaka T Maejima H Morioka M Minami | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，5： | 9 |
| 4 | Effects of six years of simulated N deposition on gross soil N transformation rates in an old-growth temperate forest显示文摘Elevated atmospheric nitrogen(N) deposition has been detected in many regions of China, but its effects on soil N transformation in temperate forest ecosystems are not well known. We therefore simulated N deposition with four levels of N addition rate(N0, N30, N60, and N120) for6 years in an old-growth temperate forest in Xiaoxing'an Mountains in Northeastern China. We measured gross N transformation rates in the laboratory using ^(15)N tracing technology to explore the effects of N deposition on soil gross N transformations taking advantage of N deposition soils. No significant differences in gross soil N transformation rates were observed after 6 years of N deposition with various levels of N addition rate. For all N deposition soils, the gross NH_4^+ immobilization rates were consistently lower than the gross N mineralization rates,leading to net N mineralization. Nitrate(NO_3^-) was primarily produced via oxidation of NH_4^+(i.e., autotrophic nitrification), whereas oxidation of organic N(i.e., heterotrophic nitrification) was negligible. Differences between the quantity of ammonia-oxidizing bacteria and ammonia-oxidizing archaea were not significant for any treatment, which likely explains the lack of a significant effect on gross nitrification rates. Gross nitrification rates were much higher than the total NO_3^- consumption rates,resulting in a build-up of NO_3^-, which highlights the high risk of N losses via NO_3^- leaching or gaseous N emissions from soils. This response is opposite that of typical N-limited temperate forests suffering from N deposition,suggesting that the investigated old-growth temperate forest ecosystem is likely to approach N saturation. | Peng Tian Jinbo Zhang Christoph Müller Zucong Cai Guangze Jin | 2018 | Journal of Forestry Research2018，29，3： | 3 |
| 5 | Effect of orchard age on soil nitrogen transformation in subtropical China and implications显示文摘A better understanding of nitrogen transformation in soils could reveal the capacity for biological inorganic N supply and improve the efficiency of N fertilizers. In this study, a15 N tracing study was carried out to investigate the effects of converting woodland to orchard, and orchard age on the gross rates of N transformation occurring simultaneously in subtropical soils in Eastern China. The results showed that inorganic N supply rate was remained constant with soil organic C and N contents increased after converting woodland into citrus orchard and with increasing orchard age. This phenomenon was most probably due to the increase in the turnover time of recalcitrant organic-N, which increased with decreasing soil p H along with increasing orchard age significantly. The amo A gene copy numbers of both archaeal and bacterial were stimulated by orchard planting and increased with increasing orchard age. The nitrification capacity(defined as the ratio of gross rate of nitrification to total gross rate of mineralization) increased following the Michaelis–Menten equation, sharply in the first 10 years after woodland conversion to orchard, and increased continuously but much more slowly till 30 years. Due to the increase in nitrification capacity and unchanged NO3-consumption, the dominance of ammonium in inorganic N in woodland soil was shifted to nitrate dominance in orchard soils. These results indicated that the risk of NO3-loss was expected to increase and the amount of N needed from fertilizers for fruit growth did not change although soil organic N accumulated with orchard age. | Yushu Zhang Jinbo Zhang Tongbin Zhu Christoph Müller Zucong Cai | 2015 | Journal of Environmental Sciences2015，27，8： | 3 |
| 6 | Source identification, contamination status and health risk assessment of heavy metals from road dusts in Dhaka, Bangladesh显示文摘In this study, concentrations of Cr, Mn, Ni, Cu, Zn, Cd and Pb were determined in road dusts collected from different locations in Dhaka to assess source, contamination status and health risk. Energy-dispersive X-ray fluorescence spectroscopy and energy-dispersive X-ray spectroscopy were used to determine Cr, Mn, Ni, Cu, Zn, Cd and Pb and their mean concentrations were 162.27 ± 29.46, 721.18 ± 180.14, 35.65 ± 12.55, 104.56 ± 128.33, 515.32 ± 321.90,BDL, and 342.82 ± 591.20 mg/kg, respectively. Among the heavy metals, highest concentrations of Cu, Zn and Pb were found at urban sites-7(municipal waste dumping) and 8(medical waste incineration). Highest concentration of Cr followed by Cu and Zn was found at site-5(Tejgaon, urban). Principal component analysis revealed that anthropogenic activities are the potential sources for Cr, Ni, Cu, Zn and Pb while earth crust for Mn. Pollution index and pollution load index results suggested that all the sites were contaminated and/or degraded by Cr, Cu, Zn and Pb except sites-9(urban), 10(sub-urban), 11(rural) while sites-7 and 8(urban) were extremely degraded. For noncarcinogenic health risk, hazard quotient values for dermal were higher compared to that of inhalation/ingestion. Though hazard index values were less than 1 at all the sites, these were at least one order of magnitude higher for children group than that of adult group, thus the children group may face more noncarcinogenic health risk at sites -7 and 8. Values of incremental lifetime cancer risk were from 10to 10showed no carcinogenic health risk by road dusts contaminated with the heavy metals. | Aklima Nargis Ahsan Habib Md Nazrul Islam Kai Chen Md Shafiqul Islam Sarker A N M Al-Razee Wenbin Liu Guorui Liu Minggang Cai | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 7 | Generalized crack initiation and crack damage stress thresholds of brittle rock masses near underground excavations显示文摘 | M Cai P.K Kaiser Y Tasaka T Maejima H Morioka M Minami | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，5： | 3 |
| 8 | Cancer chemopreventive activity of resveratrol,a natural product derived from grapes显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，： | 2 |
| 9 | Reductive soil disinfestation (RSD) alters gross N transformation rates and reduces NO and N 2 O emissions in degraded vegetable soils显示文摘 | Tongbin Zhu Qi Dang Jinbo Zhang Christoph Müller Zucong Cai | 2014 | 2014 (1-2)2014，，1： | 2 |
| 10 | Damping analysis of beams covered with multiple PCLD patches显示文摘 | Zheng H Tan X M Cai C | 2006 | International Journal of Mechanical Sciences2006，48，12： | 1 |
| 11 | A critical review on software reliability modeling显示文摘 | Cai K Wen C Zhang M | 1991 | Reliability Engineering and System Safety1991，，： | 1 |
| 12 | Significant correlation between micrometastasis in the lymph nodes and reduced expression of E-cadherin in early gastric cancer 显示文摘 | Cai J Ikeguchi M Tsujitani S | 2001 | Gastric Cancer2001，4，2： | 1 |
| 13 | Effects of free radical scavengers, methylprenisolone , and ulinastatin on acute xanthine and xanthine oxidase induced lung injury in rats显示文摘 | Cai M Ogawa R | 1994 | Circ Shock1994，43，1： | 1 |
| 14 | Damping analysis of beams covered with multiple PCLD patches显示文摘 | Zheng H Tan X M Cai C | 2006 | International Journal of Mechanical Sciences2006，48，： | 1 |
| 15 | Bis - ( μ -2 - aminoethanesulfonato) -K3 N,O:O' -bis显示文摘 | Jiang Y M Wang X J Liu Z M | 2004 | Acta Cryst E602004，，： | 1 |
| 16 | MAAN:A Multi-attribute Addressable Network for Grid Information Services显示文摘 | Cai Min Frank M Szekely P | 2004 | Journal of Grid Computing2004，2，1： | 1 |
| 17 | Tourist purchase decision involvement and information preferences显示文摘 | Cai L P Feng R M Breiter D | 2004 | Journal of Vacation Marketing2004，10，2： | 1 |
| 18 | Photocatalytic degradation of phenol in aqueous nitrogen-doped TiO2 suspensions with various light sources 显示文摘 | Wang Z P Cai W M Hong X T | 2005 | Appl Catal B Environ2005，57，： | 1 |
| 19 | The role of the Indone- sian Throughflow on ENSO dynamics in a coupled 'climate model 显示文摘 | Santoso A Cai W England M H | 2011 | Journal of Climate2011，24，： | 1 |
| 20 | Measurement of film interface ten-sion strength by the laser spallaton technique显示文摘 | ZHOU M ZHANG Y K CAI L | 2002 | Scoence in China2002，32，1： | 1 |
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