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| 1 | Scavenging of reactive oxygen and nitrogen species with nanomaterials显示文摘 | Carolina A. Ferreira Dalong Ni Zachary T. Rosenkrans Weibo Cai | 2018 | Nano Research2018，11，10： | 10 |
| 2 | In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets显示文摘Photodynamic therapy(PDT)by near-infrared(NIR)irradiation is a promising technique for treating various cancers.Here,we reported the development of free-standing wafer-scale Au nanosheets(NSs)that exhibited an impressive PDT effect.The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm.These Au NSs were found very effective in generating singlet oxygen under NIR irradiation.In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology.Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation.This performance is comparable to using 10 times mass loading of Au nanoparticles(NPs).This work suggests that two-dimensional(2D)Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency. | Ziyi Zhang Dalong Ni Fei Wang Xin Yin Shreya Goel Lazarus NGerman Yizhan Wang Jun Li Weibo Cai Xudong Wang | 2020 | Nano Research2020，13，12： | 2 |
| 3 | In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem显示文摘Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem ^(64) Cu-NOTAQD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellentimaging capability and more reliable diagnostic outcomes.By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform,as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics. | Sixiang Shi Feng Chen Shreya Goel Stephen A.Graves Haiming Luo Charles P.Theuer Jonathan W.Engle Weibo Cai | 2018 | Nano-Micro Letters2018，10，4： | 2 |
| 4 | New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology显示文摘 | Zhi-Yi Chen Yi-Xiang Wang Feng Yang Yan Lin Qiu-Lan Zhou Yang-Ying Liao Weibo Cai | 2014 | BioMed Research International2014，，： | 1 |
| 5 | Molecular imaging and therapy of cancer with radiolabeled nanoparticles显示文摘 | Hao Hong Yin Zhang Jiangtao Sun Weibo Cai | 2009 | Nano Today2009，，5： | 1 |
| 6 | Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects显示文摘 | CAI Weibo SHIN D W CHEN Kai | 2006 | Nano Lett2006，6，： | 1 |
| 7 | A Thiol-reactive ^18F-labeling agent, N- maleimide, and synthesis of RGD peptide-hased tracer for PET imaging of αvβ3 integrin expression显示文摘 | Cai Weibo Zhang Xianzhong Wu Yun | 2006 | The Journal of Nucle- ar Medicine2006，47，7： | 1 |
| 8 | Transcriptome response to phosphorus starvation in rice显示文摘 | Hongnlei Cai Weibo Xie Tong Zhu eta 1 | 2012 | Acta Physiol Plant2012，，34： | 1 |
| 9 | Are quantum dots ready for in?vivo imaging in human subjects?显示文摘 | Weibo Cai Andrew R. Hsu Zi-Bo Li Xiaoyuan Chen | 2007 | Nanoscale Research Letters2007，，6： | 1 |
| 10 | Morphological Studies on the Infraciliature of a Planktonic Ciliate,Tintinnopsis brasiliensis(Ciliophora:Tintinina)显示文摘糟糕描述的海洋的板补品有睫, Tintinnopsis brasiliensisKofoid &
坎贝尔, 1929,从 Qingdao 的太平天国的披肩镇定,中国,词法上在 protargol 受精以后基于永久准备被调查并且与另外的相关同种的物相比。根据 infraciliature,三个睫的组能被认出,它在标本之中揭示很稳定的结构并且表示 infraciliature 的模式是除了古罗马胸甲的特征,为种类鉴定的一个高度可靠的标准。 | CAI Shengfang SONG Weibo XU Dapeng CHIANG Kuoping | 2006 | Journal of Ocean University of China2006，5，1： | 1 |
| 11 | Efficient renal clearance of DNA tetrahedron nanopartides enables quantitative evaluation of kidney function显示文摘DNA tetrahedro n nano structure (DTN) is one of the simplest DNA nano structures and has bee n successfully applied for biose nsin g, imagi ng, and treatment of can cer. To facilitate its biomedical applications and pote ntial clinical tran slation, fun dame ntal un derstandi ng of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearanee of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide in sight for future optimization of DNA nano structures for biomedical applications. | Dawei Jiang Hyung-Jun lm Madeline E. Boleyn Christopher G. England Dalong Ni Lei Kang Jonathan W. Engle Peng Huang Xiaoli Lan Weibo Cai | 2019 | Nano Research2019，12，3： | 1 |
| 12 | Applications of gold nanoparticles in cancer nanotechnology显示文摘 | Weibo Cai | 2008 | Nanotechnology Science and Applications (default)2008，，： | 1 |
| 13 | Muhimodality Molecular Imaging of Tumor Angiogenesis 显示文摘 | Weibo Cai Xiaoyuan Chen | 2008 | J Nucl Med2008，49，： | 1 |
| 14 | cRGD-functionalized, DOX-conjugated, and 64 Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging显示文摘 | Xiaoqiang Yang Hao Hong Jamison J. Grailer Ian J. Rowland Alireza Javadi Samuel A. Hurley Yuling Xiao Yunan Yang Yin Zhang Robert J. Nickles Weibo Cai Douglas A. Steeber Shaoqin Gong | 2011 | Biomaterials2011，，17： | 1 |
| 15 | Transcriptome response to nitrogen starvation in rice显示文摘 | Hongmei Cai Yongen Lu Weibo Xie Tong Zhu Xingming Lian | 2012 | Journal of Biosciences2012，，4： | 1 |
| 16 | Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform显示文摘Photothermal nanotheranostics, especially in the near infrared II(NIR-II) region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II light.NIR-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSe_(x) nano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se(x = 0.43). We have also discovered that the as-prepared TeSe_(x) nano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency(77.2%),^(64)Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions. | Xiang Ling Zhaokui Jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He | 2021 | National Science Review2021，8，6： | 0 |
| 17 | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury显示文摘Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai | 2023 | Bioactive Materials2023，，1： | 0 |
| 18 | Providing free treatment for severe mental disorders in China显示文摘Following the SARS outbreak in 2003 the Chinese government substantially strengthened its public health infrastructure.One of the new programs was the‘Central Government Support for the Local Management and Treatment of Severe Mental Illnesses Project’.Initially funded in December 2004 with 6.86 million Renminbi(829,000 in 2004 US$),the ongoing project has subsequently been referred to as the‘686 Project’.The aims of the project include establishing an effective system to control and prevent violent behaviors by individuals with severe mental disorder,increasing careseeking by persons with severe mental illnesses | Yi ZHU Weibo ZHANG Yanfeng WANG Jun CAI | 2014 | 上海精神医学2014，26，2： | 0 |
| 19 | Recent biomedical advances enabled by HaloTag technology显示文摘The knowledge of interactions among functional proteins helps researchers understand disease mechanisms and design potential strategies for treatment.As a general approach,the fluorescent and affinity tags were employed for exploring this field by labeling the Protein of Interest(POI).However,the autofluorescence and weak binding strength significantly reduce the accuracy and specificity of these tags.Conversely,HaloTag,a novel self-labeling enzyme(SLE)tag,could quickly form a covalent bond with its ligand,enabling fast and specific labeling of POI.These desirable features greatly increase the accuracy and specificity,making the HaloTag a valuable system for various applications ranging from imaging to immobilization of POI.Notably,the HaloTag technique has already been successfully employed in a series of studies with excellent efficiency.In this review,we summarize the development of HaloTag and recent advanced investigations associated with HaloTag,including in vitro imaging(e.g.,POI imaging,cellular condition monitoring,microorganism imaging,system development),in vivo imaging,biomolecule immobilization(e.g.,POI collection,protein/nuclear acid interaction and protein structure analysis),targeted degradation(e.g.,L-AdPROM),and more.We also present a systematic discussion regarding the future direction and challenges of the HaloTag technique. | WEIYU CHEN MUHSIN HYOUNIS ZHONGKUO ZHAO WEIBO CAI | 2022 | BIOCELL2022，46，8： | 0 |
| 20 | Intrinsic radiolabeling of Titanium-45 using mesoporous silica nanoparticles显示文摘 | Feng CHEN Hector F VALDOVINOS Reinier HERNANDEZ Shreya GOEL Todd E BARNHART Weibo CAI | 2017 | Acta Pharmacologica Sinica2017，38，6： | 0 |
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