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| 1 | Strategies for engineering advanced nanomedicines for gas therapy of cancer显示文摘As an emerging and promising treatment method,gas therapy has attracted more and more attention for treatment of inflammation-related diseases,especially cancer.However,therapeutic/therapy-assisted gases(NO,CO,HgS,H2,O2,SO and CO2)and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release,resulting in limited cancer therapy efficacy and potential side effects.Therefore,development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired,and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also ced gas-releasingnanomedicines from four aspects:(1)stimuli-responsive strategies for controlled gas release;multi-model combination strategies based on gas therapy.Moreover,we highlight current issues and gaps in knowledge,and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer.This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.reduce their side effects.The design ofnanomedicines with these functions is vitally important,but challenging.In this review,we summarize a series of engineering strategies for construction of advar(2)catalytic strategies for controlled gas release;(3)tumor-targeted gas delivery strategies;(4) | Yingshuai Wang Tian Yang Qianjun He | 2020 | National Science Review2020，7，9： | 7 |
| 2 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 3 | Sharp bounds for Hardy type operators on higher-dimensional product spaces显示文摘Abstract We investigate a class of fractional Hardy type operators Hβ2,β2,...βm defined on higher-dimensional product spaces R^n1×R^n2×...R^nm and use novel methods to obtain their sharp result due to S.M.Wang,S.Z.Lu,and D.Y.Yan. | Qianjun HE Xiang LI Dunyan YAN | 2018 | Frontiers of Mathematics in China2018，13，6： | 3 |
| 4 | Equivalence of operator norm for Hardy-Littlewood maximal operators and their truncated operators on Morrey spaces显示文摘We will prove that for 1 | Xingsong ZHANG Mingquan WEI Dunyan YAN Qianjun HE | 2020 | Frontiers of Mathematics in China2020，15，1： | 2 |
| 5 | Whole-genome sequencing reveals selection signals among Chinese,Pakistani,and Nepalese goats显示文摘The goat(Capra hircus)is one of the oldest domesticated animal species,with archeological evidence indicating that its earliest domestication from the wild ancestor(bezoar)occurred in the Fertile Crescent 10,000 calibrated calendar years ago(Zeder and Hesse,2000).A variety of well-adapted goat breeds with excellent economic traits have been selected artificially and naturally for human needs in China,Pakistan,and Nepal.For example,cashmere goat breeds produce fine cashmere wool and are mainly distributed on the Himalayan Plateau(e.g.,Nepal and Tibet)and in cold northern China(e.g.,Inner Mongolia and Liaoning).The Toggenburg dairy goat is the most productive breed of dairy goat and is distributed in at least 50 countries on all continents(Ferro et al.,2017).Pakistani ewes are reared mostly for meat and wool purposes,but some are used as dairy goats,such as the Bugi Toori goat and Pateri goat(Bilal et al.,2018).Additionally,indigenous goats of the southern Asian regions are well adapted to the local hot environment.Their unique traits and biodiversity serve as genetic resources that can be used for the artificial breeding of goats.Recently,several studies have provided patterns of genome-wide characteristics in goat populations to explore the underlying genetic basis of trait formation and environmental adaptability in China(Zhang et al.,2018),Pakistan(Kumar et al.,2018),and Nepal(Sasazaki et al.,2021),respectively.However,due to the proximity of these geographic regions,the profiles of genetic differences,gene flow,and common genes related to high trait performance between goat populations from China,Pakistan,and Nepal remain unclear. | Yefang Li Ying Gong Zhengkai Zhang Ling Li Xuexue Liu Xiaohong He Qianjun Zhao Yabin Pu Yuehui Ma Lin Jiang | 2023 | Journal of Genetics and Genomics2023，50，5： | 2 |
| 6 | Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence显示文摘Camptothecin has a strong tumor killing ability for a variety of tumor cells with its special anti-cancer mechanism including the breast cancer. However, because of its infinite hydrophobic property, its clinical application has been greatly limited. Early prevention of loco regional recurrence for the breast cancer is critical for patients who have undergone breast-conserving therapy. In the study,CPT was used for the inhibition of the recurrence after the operation. The hollow mesoporous silica nanoparticles were used as the carrier to improve the hydrophilic property and increase its bioavailability with the high loading capacity. The ability of the cellular uptake and antitumor activity was increased. Hydrogel was the ideal carrier for local therapy, so the CPT@HMSNs were loaded into the PLEL thermo sensitive hydrogel to be injected into the tumor sites after the tumor was resected. The recurrence was reduced in the group of CPT-HMSNs-PLEL and the side effect of CPT was decreased. They exhibit distinguished potential as drug carrier for local delivery. | Jing Wu Ying Qu Kun Shi Bingyang Chu Yanpeng Jia Xue Xiao Qianjun He Zhiyong Qian | 2018 | Chinese Chemical Letters2018，29，12： | 2 |
| 7 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 8 | Fe-porphyrin:A redox-related biosensor of hydrogen molecule显示文摘Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so far.Herein,we originally reveal that Fe-porphyrin is a H_(2)-targeted molecule.We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of CO.These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials. | Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He | 2023 | Nano Research2023，16，2： | 1 |
| 9 | 显示文摘 | He Qianjun Shi Jianlin | 2011 | Journal of Materials Chemistry2011，21，16： | 1 |
| 10 | Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging显示文摘 | Qianjun He Ming Ma Chenyang Wei Jianlin Shi | 2012 | Biomaterials2012，，17： | 1 |
| 11 | A mesoporous silica nanoparticulate/ β -TCP/BG composite drug delivery system for osteoarticular tuberculosis therapy显示文摘 | Min Zhu Huixue Wang Jiyong Liu Hailong He Xuguo Hua Qianjun He Lingxia Zhang Xiaojian Ye Jianlin Shi | 2010 | Biomaterials2010，，7： | 1 |
| 12 | Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles显示文摘 | Pan Limin Liu Jianan He Qianjun | 2013 | Biomaterials2013，34，11： | 1 |
| 13 | Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles显示文摘 | Limin Pan Jianan Liu Qianjun He Lijun Wang Jianlin Shi | 2013 | Biomaterials2013，，11： | 1 |
| 14 | A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance显示文摘 | Qianjun He Yu Gao Lingxia Zhang Zhiwen Zhang Fang Gao Xiufeng Ji Yaping Li Jianlin Shi | 2011 | Biomaterials2011，，30： | 1 |
| 15 | An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles显示文摘 | Qianjun He Jianlin Shi Feng Chen Min Zhu Lingxia Zhang | 2010 | Biomaterials2010，，12： | 1 |
| 16 | Size-controlled synthesis of monodispersed mesoporous silica nano-spheres under a neutral condition显示文摘 | Qianjun He Xiangzhi Cui Fangming Cui Limin Guo Jianlin Shi | 2008 | Microporous and Mesoporous Materials2008，，3： | 1 |
| 17 | MSN Anti‐Cancer Nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance, and Metastasis Inhibition显示文摘 | Qianjun He Jianlin Shi | 2014 | Adv Mater2014，，3： | 1 |
| 18 | In vivo Biodistribution andUrinary Excretion of Mesoporous Silica Nanoparticles : Effects of ParticleSize and PEGylation显示文摘 | Qianjun He Zhiwen Zhang Fang Gao | 2011 | Small2011，，7： | 1 |
| 19 | Multifunctional nanoprobes for upconversion fluorescence, MR and CT trimodal imaging显示文摘 | Huaiyong Xing Wenbo Bu Shengjian Zhang Xiangpeng Zheng Ming Li Feng Chen Qianjun He Liangping Zhou Weijun Peng Yanqing Hua Jianlin Shi | 2011 | Biomaterials2011，，4： | 1 |
| 20 | Diffusion Kinetics of Carbonate Hydroxyapatite (CHAP) for Adsorbing F^- Dissolved in Water显示文摘系统的研究关于吸附的散开动力学被执行在为从被与 CO_3^(2-) 掺杂修改的自然 hydroxyapatite 的碳酸盐 hydroxyapatite (章) 的水里溶解 F~ 。当F~集中是相对低的时,F^-吸附的速度被膜散开控制的结果表演,被散开 Q=0.0005 的运动方程表示, C_i - C )( t - t_i ) +0.3967 ,或由空缺散开当F~集中相对高时,它被散开 ln 的运动方程表示[ C ( o , t )]为吸附F^-基于章的特征的 =8.4718-0.5048Int 溶解在水和它CO_3^(2-)的结构的特殊隧道里-修改 hydroxyapatite ,空缺散开和膜散开的模型被建立。 | HUANG Zhiliang ZHANG Lianmeng LIU Yu WANG Qilin HE Qianjun CHEN Wei | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 1 |
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