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| 1 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019,2,1: | 2 |
| 2 | Architecting Fault Tolerance with Exception Handling: Verification and Validation显示文摘When building dependable systems by integrating untrusted software components that were not originally designed to interact with each other, it is likely the occurrence of architectural mismatches related to assumptions in their failure behaviour. These mismatches, if not prevented during system design, have to be tolerated during runtime. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software systems. This abstraction comprises several components and connectors that promote an existing untrusted software element into an idealised fault-tolerant architectural element. Moreover, it is considered in the context of a rigorous software development approach based on formal methods for representing the structure and behaviour of the software architecture. The proposed approach relies on a formal specification and verification for analysing exception propagation, and verifying important dependability properties, such as deadlock freedom, and scenarios of architectural reconfiguration. The formal models are automatically generated using model transformation from UML diagrams: component diagram representing the system structure, and sequence diagrams representing the system behaviour. Finally, the formal models are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an embedded critical case study. | Patrick H. S. Brito Rogério de Lemos Cecília M. F. Rubira Eliane Martins | 2009 | Journal of Computer Science & Technology2009,24,2: | 2 |
| 3 | The brain as a source and a target of prolactin in mammals显示文摘Prolactin is a polypeptide hormone associated with an extensive variety of biological functions.Among the roles of prolactin in vertebrates,some were preserved throughout evolution.This is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous system.In the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to parenthood.Prolactin is mainly produced by specialized cells in the anterior pituitary gland.However,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the brain.This review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided. | Ana R.Costa-Brito Isabel Gonçalves Cecília R.A.Santos | 2022 | Neural Regeneration Research2022,17,8: | 2 |
| 4 | Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?显示文摘 | Cecília Dur?es Gabriela M. Almeida Raquel Seruca Carla Oliveira Fátima Carneiro | 2014 | Virchows Archiv2014,,: | 2 |
| 5 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009,,9: | 1 |
| 6 | Bone secondaries in breast cancer:the solitary metastasis显示文摘 | Todd CEC Coleman R | 1989 | J Nucl Med1989,30,8: | 1 |
| 7 | Profiling the Nature-based Tourist:A Multi-nominallogit Approach显示文摘 | Luzar EJ Diagne A Gan CEC | 1998 | Journal of Travel Research1998,37,1: | 1 |
| 8 | Mi- crostructure of NiTi orthodontic wires observations using transmission electron microscopy显示文摘 | FER CEC J JENKO D BUCHMEISTER B | 2014 | Metalurgija2014,53,4: | 1 |
| 9 | The cardiovascular aspects of a Ménière’s disease population——A pilot study显示文摘Introduction:MD is considered a rare disease.An adequate model that explains MD's pathophysiology is not well established.Recently,the vascular theory of the disease has been revived.Objectives:To characterize a MD population according to its cardiovascular risk and correlate it to the MD clinical course.Methods:In this retrospective chart study the data of 31 MD patients observed between January 2017 and April 2018 in a tertiary university hospital were reviewed.Patients included in the study were diagnosed according to the Barany Society criteria.Lost follow-ups,patients with autoimmune disease,atopy or allergy,major psychiatric disease and migraine were excluded.Age,gender,cardiovascular risk factors,audiometric and vestibular parameters,occurrence of MD attacks in the previous 6 months,vestibular medication in course and time course of MD were recorded and compared between groups(with and without cardiovascular risk factors).Results:31 patients(61.3%females)mean aged 60.3 years(±9.7)were studied.74%of the population had at least one risk factor and 51.6%of patients had attacks in the last 6 months.There was a statistically significant difference in the occurrence of MD attacks in the last 6 months(p=0.014)between MD patients with and without risk factors.Mean PTA thresholds were higher and speech discrimination was lower in individuals with more cardiovascular risk factors.Conclusions:Treatment of MD focusing on vascular risk factors may allow a better control of symptoms and result in a decreased need for ablative procedures in this disorder. | Angela Reis Rego David Dias Ana Pinto SANDra Sousa e Castro Telma Feliciano Cecília Almeida e Sousa | 2019 | Journal of Otology2019,14,2: | 1 |
| 10 | Antitumor activity of(-)-alpha-bisabololbased thiosemicarbazones against human tumor cell lines显示文摘 | Alan P da Silvaa Manuele V Martinia Cecília M de Oliveira | 2010 | Eur J Med Chem2010,45,7: | 1 |
| 11 | Antioxidant Acton of Bixin Against CisplatinInduced Chromosome Aberrations and Lipid Peroxidation in Rats显示文摘 | Cec(I)lia Rodrigues Siva Lus(a)nua M Greggu Abtyes abd Maria De Lourdes P | 2001 | Pharmacological Research2001,43,6: | 1 |
| 12 | The first record in the Americas of an autochthonous case of Leishmania ( Leishmania ) infantum chagasi in a domestic cat ( Felix catus ) from Cotia County, S?o Paulo State, Brazil显示文摘 | Elisa San Martin Mouriz Savani Maria Cec??lia Gibrail de Oliveira Camargo Mar??lia Russi de Carvalho Ricardo Andrade Zampieri Marcos Gonzaga dos Santos Sandra Regina Nicoletti D’áuria Jeffrey J Shaw Lucile Maria Floeter-Winter | 2004 | Veterinary Parasitology2004,,3: | 1 |
| 13 | Amyloid-β Peptide-Induced Secretion of Endoplasmic Reticulum Chaperone Glycoprotein GRP94显示文摘 | Ricardo J.S. Viana Clifford J. Steer Cecília M.P. Rodrigues | 2011 | Journal of Alzheimer’s Disease2011,,1: | 1 |
| 14 | Deacidification of vegetable oils by solvent extraction显示文摘 | Rodrigues CEC Cintia B G Eduardo B | 2007 | Recent Patents on Engineering2007,,1: | 1 |
| 15 | Phase equilibrium for the system rice bran oil+fatty acids+ethanol+water+γoryzanol+tocols显示文摘 | Rodrigues CEC Filho PAP Meirelles AJA | 2004 | Fluid Phase Equilibria2004,216,: | 1 |
| 16 | Phase equilibriumfor the system rice bran oil + fatty acids + ethanol + water +'yoryzanol+tocols显示文摘 | Rodrigues CEC Filho PAP Meirelles AJA | | 0,,: | 1 |
| 17 | MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells显示文摘 | Pedro M.Borralho Betsy T.Kren Rui E.Castro Isabel B.Moreira da Silva Clifford J.Steer Cecília M. P.Rodrigues | 2009 | FEBS Journal2009,,22: | 1 |
| 18 | Minor-groove recognition of dou- ble-stranded RNA by the double-stranded RNA-binding do- main from the RNA-activated protein kinase PKR显示文摘 | Bevilaequa P C Cec h T R | 1996 | Biochem- istry1996,35,31: | 1 |
| 19 | Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease显示文摘 | Camila Andrade Mendes Medeiros Pedro Felipe Carvalhedo de Bruin Lívia Ariane Lopes Maria Cecília Magalh?es Maria de Lourdes Seabra Veralice Meireles Sales de Bruin | 2007 | Journal of Neurology2007,,4: | 1 |
| 20 | Assessing Genetic Diversity of Brazilian Reef Fishes by Chromosomal and DNA Markers显示文摘 | Pedro Manoel Galetti Junior Wagner Franco Molina Paulo Roberto A. M. Affonso Cecília Teixeira Aguilar | 2006 | Genetica (-)2006,,12: | 1 |