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| 1 | Simultaneous Paragonimus infection involving the breast and lung:A case report显示文摘BACKGROUND Paragonimiasis is a food-borne parasitic infection caused by lung flukes of the genus Paragonimus. Although the most common site of infection is the pleuropulmonary area, the parasite can also reach other parts of the body on its journey from the intestines to the lungs, ending up in locations such as the brain,abdomen, skin, and subcutaneous tissues. Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.CASE SUMMARY Here, we report a rare case of simultaneous breast and pulmonary paragonimiasis in a woman presenting painless breast mass and lung nodule with a history of eating raw trout. To confirm the diagnosis, serologic testing and tissue confirmation of the breast mass were performed. The patient was treated with surgical resection of the mass and praziquantel medication.CONCLUSION Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.Thus, thorough history-taking and clinical suspicion of parasitic infection are important. | Moon Young Oh Ajung Chu Jeong Hwan Park Jong Yoon Lee Eun Youn Roh Young Jun Chai Ki-Tae Hwang | 2019 | World Journal of Clinical Cases2019，7，24： | 5 |
| 2 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 3 | Inhibitory effects of Agaricus blasei on mast cell-mediated anaphylaxis-like reaction 显示文摘 | Choi YH Yah GH Chai OH ct al | 2006 | Biol Pharm Bull2006，29，7： | 1 |
| 4 | Synergistic Inhibition of Clostridium Difficile with Nisin-lysozyme Combination Treat- ment显示文摘 | CHAI C LEE K S OH S W | 2015 | Anaerobe2015，34，： | 1 |
| 5 | Inhibitory effects of houttuynia cordata water extracts on anaphylactic reaction and mast cell activation显示文摘 | I Li GZh Chai OH Lee MS | 2005 | Biol Pharm Bull2005，28，10： | 1 |
| 6 | PPAR-7 modulates allcrgic inflammation through up-regulation of PTEN显示文摘 | Lee KS Park SJ Hwang PH Yi HK Song CH Chai OH | 2005 | FASEB J2005，19，8： | 1 |
| 7 | Inhibitory effects of Agaricus blasei on mast cell-mediated anaphylaxis-like reaction显示文摘 | Choi YH Yan GH Chai OH | 2006 | Biol Pharm Bull2006，29，： | 1 |
| 8 | Negative effects of curcumin on liver injury induced by alcohol显示文摘 | Zhao HL Song CH Chai OH | 2012 | Phytother Res2012，26，12： | 1 |
| 9 | In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells显示文摘 | Oh GS Pae HO Oh H Hong SG Kim IK Chai KY | 2001 | Cancer Lett2001，174，1： | 1 |
| 10 | Inhibitory effects of agaricus blazei on mast cell-mediated anaphylaxis-like reactions显示文摘 | Choi YH Yan GH Chai OH | | 0，，07： | 1 |
| 11 | Roles of TNF-alpha and IgE in the late phase of contact hypersensitivity induced by trimellitic anhydride显示文摘 | Chai OH Lee HK Lee YC | | 0，，05： | 1 |
| 12 | 查看详情显示文摘 | Chun S H Chai Y S Jeon B G Kim H J Oh Y S Kim I Kim H Jeon B J Haam S Y Park J Y Lee S H Chung J H Park J H Kim K H | | 0，，： | 1 |
| 13 | Inhibition of anaphylaxis -like reac- tion anti mast cell active - tion by water extract from the fruiting body of Phellinus linteus显示文摘 | Choi YH Yah GH Chai OH | 2006 | Biological & Pharmaceutical Bulletin2006，29，7： | 1 |
| 14 | Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of phellinus linteus 显示文摘 | Choi YH Yan GH Chai OH | 2006 | Biol Pharm Bull2006，29，7： | 1 |
| 15 | Amplification and sequencing of Trichuris trichiura ancient DNA extracted from archaeologi- cal sediments显示文摘 | Oh CS Seo M Chai JY | 2010 | J Archaeol Sc2010，37，： | 1 |
| 16 | PPAR-gamma modulates allergic inflammation through up-regulation of PTEN 显示文摘 | Lee KS Park SJ Hwang PH Yi HK Song CH Chai OH | 2005 | FASEB J2005，19，8： | 1 |
| 17 | Realization of Giant Magnetoelectricity in Helimagnets显示文摘 | Sae Hwan Chun Yi Sheng Chai Yoon Seok Oh | 2010 | Physical Review Letters2010，104，： | 1 |
| 18 | The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction显示文摘We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after CNCI.At 2 weeks after surgery,erectile response was assessed using electrostimulation.Penile tissues were processed for histological studies and western blot.Group I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group S.In all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were improved.Group I+L+U showed greater improvement in erectile response than Group I+L.SM content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group I.However,Group I+L did not show a significant improvement in SM content or apoptotic index.The number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+U.Akt/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+L.LIMK2/cofilin phosphorylation was improved in Groups I+L and I+L+U,but not in Group I+U.Our data indicate that combined treatment of LIMK2i and PDE5i immediate after CN injury could improve erectile function by improving cavernous apoptosis or eNOS phosphorylation and suppressing cavernous fibrosis.Rectification of Akt/eNOS and LIMK2/cofilin pathways appears to be involved in their improvement. | Min Chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong Kim | 2019 | Asian Journal of Andrology2019，21，5： | 1 |
| 19 | Epidemiology,clinical characteristics and antimicrobial resistancepatterns of community-acquired pneumonia in 1702 hospitalizedchildren in Singapore显示文摘 | Chiang WC Teoh OH Chong CY Goh A Tang JP Chay OM | 2007 | Respirology2007，12，2： | 1 |
| 20 | Inhibitory effects of Agaricus blazei on mast cell-mediated anaphylaxis-like reaction显示文摘 | CHOI YH YAN GH CHAI OH | 2006 | Biol Pharm Bull2006，29，7： | 1 |
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