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| 1 | Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy显示文摘 | Keliang Wu Cuiqing Zhong Tailai Chen Xiaoyu Zhang Wenrong Tao Jingye Zhang Hongchang Li Han Zhao Jinsong Li Zi-Jiang Chen | 2017 | Cell Research2017，27，8： | 13 |
| 2 | Neddylation of PTEN regulates its nuclear import and promotes tumor development显示文摘PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus.Nucleus–cytoplasm shuttling of PTEN is regulated by ubiquitylation,SUMOylation and phosphorylation,and nuclear PTEN has been proposed to exhibit tumor-suppressive functions.Here we show that PTEN is conjugated by Nedd8 under high glucose conditions,which induces PTEN nuclear import without effects on PTEN stability.PTEN neddylation is promoted by the XIAP ligase and removed by the NEDP1 deneddylase.We identify Lys197 and Lys402 as major neddylation sites on PTEN.Neddylated PTEN accumulates predominantly in the nucleus and promotes rather than suppresses cell proliferation and metabolism.The nuclear neddylated PTEN dephosphorylates the fatty acid synthase(FASN)protein,inhibits the TRIM21-mediated ubiquitylation and degradation of FASN,and then promotes de novo fatty acid synthesis.In human breast cancer tissues,neddylated PTEN correlates with tumor progression and poor prognosis.Therefore,we demonstrate a previously unidentified pool of nuclear PTEN in the Nedd8-conjugated form and an unexpected tumor-promoting role of neddylated PTEN. | Ping Xie Zhiqiang Peng Yujiao Chen Hongchang Li Mengge Du Yawen Tan Xin Zhang Zhe Lu Chun-Ping Cui Cui Hua Liu Fuchu He Lingqiang Zhang | 2021 | Cell Research2021，31，3： | 11 |
| 3 | SGuard:A Lightweight SDN Safe-Guard Architecture for DoS Attacks显示文摘Software Defined Networking(SDN) is a revolutionary networking paradigm towards the future network,experiencing rapid development nowadays.However,its main characteristic,the separation of control plane and data plane,also brings about new security challenges,i.e.,Denial-of-Service(DoS) attacks specific to Open Flow SDN networks to exhaust the control plane bandwidth and overload the buffer memory of Open Flow switch.To mitigate the DoS attacks in the Open Flow networks,we design and implement SGuard,a security application on top of the NOX controller that mainly contains two modules:Access control module and Classification module.We employ novel six-tuple as feature vector to classify traffic flows,meanwhile optimizing classification by feature ranking and selecting algorithms.All the modules will cooperate with each other to complete a series of tasks such as authorization,classification and so on.At the end of this paper,we experimentally use Mininet to evaluate SGuard in a software environment.The results show that SGuard works efficiently and accurately without adding more overhead to the SDN networks. | Tao Wang Hongchang Chen | 2017 | China Communications2017，14，6： | 10 |
| 4 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 5 | A Game-Theoretic Approach to Elastic Control in Software-Defined Networking显示文摘Elastic control could balance the distributed control plane in Software-Defined Networking(SDN). Dynamic switch migration has been proposed to achieve it. However, existing schemes mainly focus on how to execute migration operation, but not why. This paper designs a decision-making mechanism based on zero-sum game theory to reelect a new controller as the master for migrated switches. It first chooses a switch for migration in the heavy controller which invites its neighbors as the game players to compete for the master role of this switch in the game-playing field(GPF) which is an occasional and loose domain for game-playing. Second, based on the concept of GPF, we design a decentralized strategy to play the game and determine which player as the final master. We implement it by extending the Open Flow protocol. Finally, numerical results demonstrate that our distributed strategy can approach elastic control plane with better performance. | Hongchang Chen Guozhen Cheng Zhiming Wang | 2016 | China Communications2016，13，5： | 5 |
| 6 | Toward a Scalable SDN Control Mechanism via Switch Migration显示文摘Dynamic Controller Provisioning Problem(DCPP) is a key problem for scalable SDN. Previously, the solution to this problem focused on adapting the number of controllers and their locations with changing network conditions, but ignored balancing control loads via switch migration. In this paper, we study a scalable control mechanism to decide which switch and where it should be migrated for more balanced control plane, and we define it as Switch Migration Problem(SMP). The main contributions of this paper are as follows. First, we define a SDN model to describe the relation between controllers and switches from the view of loads. Based on this model, we form SMP as a Network Utility Maximization(NUM) problem with the objective of serving more requests under available control resources. Second, we design a synthesizing distributed algorithm for SMP--- Distributed Hopping Algorithm(DHA), by approximating our optimal objective via Log-Sum-Exp function. In DHA, individual controller performs algorithmic procedure independently. With the solution space F, we prove that the optimal gap caused by approximation is at most 1/βlog|F|, and DHA procedure is equal to implementation of a time-reversible Markov Chain process. Finally, the results are corroborated by several numerical simulations. | Guozhen Cheng Hongchang Chen Hongchao Hu Zhiming Wang | 2017 | China Communications2017，14，1： | 3 |
| 7 | Enabling network function combination via service chain instantiation显示文摘 | Guozhen Cheng Hongchang Chen Hongchao Hu Zhiming Wang Julong Lan | 2015 | Computer Networks2015，，： | 2 |
| 8 | SecIngress:An API Gateway Framework to Secure Cloud Applications Based on N-Variant System显示文摘Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation. | Dacheng Zhou Hongchang Chen Guozhen Cheng Weizhen He Lingshu Li | 2021 | China Communications2021，18，8： | 2 |
| 9 | Productivity change in Chinese industry:1953-1985显示文摘 | Chen Kuan Hongchang Wang Yuxin Zheng Gary H.Jefferson Thomas G.Rawski | | 0，，04： | 1 |
| 10 | A Mixed Direct Method for Transient Stability Assessment显示文摘 | Chang Hongchan Chen Hongchang | 1993 | Journal of the Chinese Institute of Engineers1993，，： | 1 |
| 11 | Productivity change in Chinese industry:1953-1985显示文摘 | Chen Kuan Wang Hongchang Zheng Yuxin Jefferson GH Rawski T G | 1988 | Journal of Comparative Economics1988，90，12： | 1 |
| 12 | Defending Against Link Failure in Virtual Network Embedding Using a Hybrid Scheme显示文摘Nowadays network virtualization is utterly popular.As a result,how to protect the virtual networks from attacking on the link is increasingly important.Existing schemes are mainly backup-based,which suffer from data loss and are helpless to such attacks like data tampering.To offer high security level,in this paper,we first propose a multipath and decision-making(MD) scheme which applies multipath simultaneously delivery and decision-making for protecting the virtual network.Considering different security requirement for virtual link,we devise a hybrid scheme to protect the virtual links.For the critical links,MD scheme is adopted.For the other links,we adopt the Shared Backup Scheme.Our simulation results indicate the proposed scheme can significantly increase the security level of the critical link high in the loss of less acceptance ratio. | Jianjian Ai Hongchang Chen Zehua Guo Guozhen Cheng | 2019 | China Communications2019，16，1： | 1 |
| 13 | Applications and grants of National Natural Science Foundation of China’s General Program in cardiovascular research:a 10-year review显示文摘Cardiovascular diseases(CVDs)are the major threats to global human health and the leading causes of mortality and morbidity in China(Liu et al.,2019).Although various strategies have been developed,the prevalence of CVDs is still increasing in China,and many CVDs cannot be managed well(Liu et al.,2019)because of the lack of full elucidation on many basic issues. | Juejin Wang Zhaoyang Chen Hongchang Guo Rui Wang Ruijuan Sun | 2023 | Science China(Life Sciences)2023，66，3： | 1 |
| 14 | Developments of crawler steering gearbox for combine harvester straight forward and steering in situ显示文摘Soil compaction and accumulation are caused by crawler steering.Soil characteristics would affect the ability of crawler straight forward and steering in situ.This paper studied the principle of straight forward steering and steering in situ mode of traditional unilateral brake steering gearbox of a crawler combine harvester.Then a positive and negative steering gearbox model was developed and processed.The performance of positive and negative steering gearbox was analyzed by performing two steering modes on soil compaction effect.Results showed that the positive and negative steering gearboxes can achieve three operating modes,such as straight forward,unilateral brake steering,and positive and negative steering in situ.The positive and negative steering in situ was smooth and without soil accumulation phenomenon.When the crawlers center distance,crawler grounding length,crawler width were 1150 mm,1620 mm and 450 mm respectively,the rolling area and the scratch free area of positive and negative steering gearbox were 5.37 m2 and 0.36 m2 respectively.However,the rolling area and the scratch free area produced by unilateral brake steering gearbox were 13.92 m2 and 1.88 m2 respectively,which was 8.55 m2 larger than that of positive and negative steering gearbox.The crawler with positive and negative steering gearbox has minor damage to paddy soil.This research can provide a theoretical basis for the smooth steering in situ and structural optimization of the crawler steering gearbox. | Zhong Tang Haotian Zhang Hongchang Li Yaoming Li Zhao Ding Jinsong Chen | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 1 |
| 15 | CeO2/TiO2 Monolith Catalyst for the Selective Catalytic Reduction of NOx with NH3: Influence of H2O and SO2显示文摘 | ZHANG Fan TIAN Gang WANG Hongmei WANG Hongchang ZHANG Chen CUI Yutao HUANG Jiayu SHU Yun | 2016 | Chemical Research in Chinese Universities2016，32，3： | 1 |
| 16 | Hardwarein-the-loop simulation of pneumatic ABS based on modelica显示文摘 | Zhang Hongchang Zhang Yunqing Chen Liping | 2010 | International Journal of CAD/CAM2010，10，1： | 1 |
| 17 | Nanoengineering core / shell structured brucite @ polyphosphate @ amine hybrid system for enhanced flame retardant properties显示文摘 | Wang Xuesong Pang Hongchang Chen Wendan | 2013 | Polymer Degradation and Stability2013，98，12： | 1 |
| 18 | High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer显示文摘 | Miaomiao Yang Hongchang Shen Chen Qiu Yang Ni Liguang Wang Wei Dong Yida Liao Jiajun Du | 2012 | European Journal of Cancer2012，，： | 1 |
| 19 | Nanoengineering core/shell structured brucite@polyphosphate@amine hybrid system for enhanced flame retardant properties显示文摘 | Wang Xuesong Pang Hongchang Chen Wendan | 2013 | Polymer Degradation and Stability2013，98，12： | 1 |
| 20 | TiN nanocrystal anchored on N-doped graphene as effective sulfur hosts for high-performance lithium-sulfur batteries显示文摘Lithium-sulfur(Li-S)batteries have become prospective candidates for next-generation energy storage owing to the high energy density and low cost.However,the sluggish kinetics of the electrochemical reaction and shuttle effect result in a rapid capacity decay.Herein,a titanium nitride nanocrystal/Ndoped graphene(TiN@NG)composite is developed to host elemental sulfur.The TiN nanoparticles decorated on graphene sheets attract Li polysulfides(LiPSx)and catalyze the electrochemical reduction and oxidation of LiPSx in the discharge and charge processes,respectively.These two effects effectively restrain the dissolution of the LiPSx and accelerate the electrochemical reactions,thereby,alleviating the shuttle effect.As a result,the cathode composed of TiN@NG/S delivers a remarkable reversible capacity(1390 mA h g^(-1) at 0.1 C)and excellent cycling performance(730 mA h g^(-1) after 300 cycles).We believe that this work can bring some inspiration for designing high-performance Li-S batteries. | Wenmiao Chen Hongchang Jin Shuai Xie Huanyu Xie Junfa Zhu Hengxing Ji Li-Jun Wan | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
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