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| 1 | Response of soil heat-water processes to vegetation cover on the typical permafrost and seasonally frozen soil in the headwaters of the Yangtze and Yellow Rivers显示文摘The response of soil temperature and moisture to vegetative cover in the active layer of permafrost and seasonally frozen soil were assessed and compared. Soil temperature and moisture, under a range of vegetation covers (92%, 65% and 30%) in the permafrost and vegetation covers (95%, 70%―80%, 40%―50% and 10%) in the seasonally frozen soil, were measured on a daily basis. A decline in vege-tation cover led to a decrease in the integral of freezing depth of active permafrost layer, but an increase in seasonally frozen soil. The maximum invasion depth and duration of the negative isotherm during the frozen period and of the positive isotherm during the non-frozen period clearly increased when vegetation cover declined. With a reduction of vegetation cover, the soil moisture in the active layer of the permafrost decreased for depths of 0.20―0.60 m, but increased for depths of 0.60―0.80 m, while for seasonally frozen soil, soil moisture of the entire profile (0.10―1.20 m) increased. Variation in vegetation cover alters soil heat-water processes, but the response to it is different between permafrost and seasonally frozen soil. | HU HongChang WANG GenXu WANG YiBo LIU GuangSheng LI TaiBing REN DongXing | 2009 | Chinese Science Bulletin2009，54，7： | 18 |
| 2 | Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy显示文摘 | Keliang Wu Cuiqing Zhong Tailai Chen Xiaoyu Zhang Wenrong Tao Jingye Zhang Hongchang Li Han Zhao Jinsong Li Zi-Jiang Chen | 2017 | Cell Research2017，27，8： | 13 |
| 3 | Neddylation of PTEN regulates its nuclear import and promotes tumor development显示文摘PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus.Nucleus–cytoplasm shuttling of PTEN is regulated by ubiquitylation,SUMOylation and phosphorylation,and nuclear PTEN has been proposed to exhibit tumor-suppressive functions.Here we show that PTEN is conjugated by Nedd8 under high glucose conditions,which induces PTEN nuclear import without effects on PTEN stability.PTEN neddylation is promoted by the XIAP ligase and removed by the NEDP1 deneddylase.We identify Lys197 and Lys402 as major neddylation sites on PTEN.Neddylated PTEN accumulates predominantly in the nucleus and promotes rather than suppresses cell proliferation and metabolism.The nuclear neddylated PTEN dephosphorylates the fatty acid synthase(FASN)protein,inhibits the TRIM21-mediated ubiquitylation and degradation of FASN,and then promotes de novo fatty acid synthesis.In human breast cancer tissues,neddylated PTEN correlates with tumor progression and poor prognosis.Therefore,we demonstrate a previously unidentified pool of nuclear PTEN in the Nedd8-conjugated form and an unexpected tumor-promoting role of neddylated PTEN. | Ping Xie Zhiqiang Peng Yujiao Chen Hongchang Li Mengge Du Yawen Tan Xin Zhang Zhe Lu Chun-Ping Cui Cui Hua Liu Fuchu He Lingqiang Zhang | 2021 | Cell Research2021，31，3： | 11 |
| 4 | Convergence Rates of Wavelet Estimators in Semiparametric Regression Models Under NA Samples显示文摘Consider the following heteroscedastic semiparametric regression model: y_i = Xi T β + g(ti) + σiei, 1 ≤ i ≤ n, where {Xi, 1 ≤ i ≤ n} are random design points, errors {ei, 1 ≤ i ≤ n} are negatively associated (NA) random variables, σi2 = h(ui), and {ui} and {ti} are two nonrandom sequences on [0, 1]. Some wavelet estimators of the parametric component β, the non- parametric component g(t) and the variance function h(u) are given. Under some general conditions, the strong convergence rate of these wavelet estimators is O(n^(-1/3) log n). Hence our results are extensions of those results on independent random error settings. | Hongchang HU Li WU | 2012 | Chinese Annals of Mathematics,Series B2012，33，4： | 9 |
| 5 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 6 | Novel application of bergapten and quercetin with anti-bacterial,osteogenesis-potentiating,and anti-inflammation tri-effects显示文摘The bacteria-mediated inflammatory conditions adversely affect the osseointegration process of endosseous implants,which can even lead to implant malfunction or failure.Local drug delivery has been designed to exert anti-inflammatory and antibacterial activities,but whether this strategy has an effect on the compromised osseointegration under inflammation has rarely been studied.The present study focused on the osteoinductive efficacy of two known phytoestrogens[bergapten(BP)and quercetin(QE)]on implant sites under multiple bacteria-infected conditions in situ.Furthermore,the gene expression profiles of rat bone mesenchymal stem cells(rBMSCs)treated with BP and QE in the presence of Porphyromonas gingivalis-derived lipopolysaccharide were identified.The results showed that both drugs,especially QE,had significant potentiating effects on promoting osteogenic differentiation of rBMSCs,resisting multiple pathogens,and reducing inflammatory activity.Meanwhile,RNA sequencing analysis highlighted the enriched gene ontology terms and the differentially expressed genes(Vps25,Il1r2,Csf3,Efemp1,and Ccl20)that might play essential roles in regulating the above tri-effects,which provided the basis for the drug delivery system to be used as a novel therapeutic strategy for integrating peri-implant health.Overall,our study confirmed that QE appeared to outperform BP in osteogenesis and bacterial killing but not in anti-inflammation.Moreover,both drugs possess favorable tri-effects and can serve as the pivotal agents for the drug delivery system to boost osseointegration at inflammatory implant sites. | Jianxu Wei Xiaomeng Zhang Yuan Li Xinxin Ding Yi Zhang Xue Jiang Hongchang Lai Junyu Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 4 |
| 7 | Response of gaseous carbon emissions to low-level salinity increase in tidal marsh ecosystem of the Min River estuary,southeastern China显示文摘Although estuarine tidal marshes are important contributors to the emission of greenhouse gases into the atmosphere, the relationship between carbon dioxide(CO_2), methane(CH_4)emission, and environmental factors, with respect to estuarine marshes, has not been clarified thoroughly. This study investigated the crucial factors controlling the emission of CO_2 and CH_4from a freshwater marsh and a brackish marsh located in a subtropical estuary in southeastern China, as well as their magnitude. The duration of the study period was November 2013 to October 2014. Relevant to both the field and incubation experiments, the CO_2 and CH_4emissions from the two marshes showed pronounced seasonal variations. The CO_2 and CH_4emissions from both marshes demonstrated significant positive correlations with the air/soil temperature(p < 0.01), but negative correlations with the soil electrical conductivity and the pore water/tide water Cl-and SO_4^(2-)(p < 0.01). The results indicate no significant difference in the CO_2 emissions between the freshwater and brackish marshes in the subtropical estuary, whereas there was a difference in the CH_4 emissions between the two sites(p < 0.01). Although future sea-level rise and saltwater intrusion could reduce the CH_4 emissions from the estuarine freshwater marshes, these factors had little effect on the CO_2 emissions with respect to an increase in salinity of less than 5‰. The findings of this study could have important implications for estimating the global warming contributions of estuarine marshes along differing salinity gradients. | Minjie Hu Hongchang Ren Peng Ren Jiabing Li Benjamin J.Wilson Chuan Tong | 2017 | Journal of Environmental Sciences2017，29，2： | 3 |
| 8 | Effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation显示文摘OBJECTIVE: To observe the effect of 'Yang-warming and kidney essence-replenishing' herbal paste on cold-related asthma exacerbation. METHODS: One hundred and fifty one patients with moderate to severe persistent asthma were randomly divided into a treatment group (n=74) and a control group (n=69). Both groups were given basic treatment according to the Global Initiative for Asthma scheme. The treatment group was also treated with herbal paste in the winter. The frequency of asthma exacerbation, cold and cold-re-lated asthma exacerbation, scores of the asthma control test (ACT), and kidney-deficiency syndrome during the one-year follow-up in each group were recorded. RESULTS: Compared with the control group, the onset frequencies of catching cold, asthma exacerbation, cold-related asthma exacerbation, and kidney-deficiency syndrome score were significantly reduced. There was no significant difference in scores of ACT between the two groups. CONCLUSION: 'Yang-warming and kidney essence-replenishing' herbal paste could reduce cold-related asthma exacerbation. | Binqing Tang Kehua Shi Xiaoqi Li Hongchang Wang Hong Fang Bidan Xiong Yingen Wu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 3 |
| 9 | Microbiologically influenced corrosion of 304 stainless steel by halophilic archaea Natronorubrum tibetense显示文摘The corrosion behavior of 304 stainless steel(SS)in the presence of aerobic halophilic archaea Natronorubrum tibetense was investigated.After 14 days of immersion,no obvious pitting pit was observed on the SS surface in the sterile medium.By contrast,the SS exhibited serious pitting corrosion with the largest pit depth of 5.0μm in the inoculated medium after 14 days.The results of electrochemical tests showed that the barrier property of the passive film decreased faster in the inoculated medium.The X-ray photoelectron spectroscopy results indicated that the detrimental Fe2+and Cr6+increased in the passive film under the influence of archaea N.tibetense,which resulted in the accelerated deterioration of passive film and promoted the pitting corrosion.Combined with the energy starvation tests,the microbiologically influenced corrosion mechanism of 304 SS caused by halophilic archaea N.tibetense was discussed finally. | Hongchang Qian Lingwei Ma Dawei Zhang Ziyu Li Luyao Huang Yuntian Lou Cuiwei Du | 2020 | Journal of Materials Science & Technology2020，42，11： | 3 |
| 10 | Ultrasound-guided percutaneous microwave ablationfor small liver cancers adjacent to large vessels:long-term outcomes and strategies显示文摘Objective The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation(MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment strategies.Methods From March 2009 to July 2015,a total of 86 patients with 94 tumors underwent ultrasound(US)-guided percutaneous MWA,with pathologically proven or clinically diagnosed liver cancers measuring ≤ 3 cm in diameter and located ≤ 10 mm from a major vessel(n = 94).Regular follow-up after MWA was performed to assess treatment efficacy and perioperative complications.Results The complete ablation rate at 1 month after MWA was 93.3%(84/90).The 6-,9-,12-,24-,36-,48-,60-,72-,and 84-month local recurrence rates were 2.4%,2.4%,3.7%,6.6%,8.4%,8.4%,8.4%,8.4%,and 8.4%,respectively.There were no major complications.The perioperative special complication rate was 5.32%(5/94),including 3 cases of moderate liver function damage and 2 cases of limited sub-capsular hematoma.Conclusion Percutaneous MWA for small hepatic cancers adjacent to large vessels is feasible,effective,and safe with an acceptable rate of complications.The key point is to strictly follow operative indications and adopt proper treatment strategies. | Ruobing Liu Kaiyan Li Hongchang Luo Wei Zhang Tingting Zhang Meng Gao Wenhui Zha Xinwu Cui Youbin Deng | 2017 | Oncology and Translational Medicine2017，3，2： | 3 |
| 11 | Development of wind-energy modeling technology and standards显示文摘To ensure the stable operation of power systems with large proportions of wind power,China has published a series of national,industry,and enterprise standards for wind power.The increase in the number of standards and the expansion of their application scope have given rise to a situation where multiple standards overlap and conflict with regard to the establishment of models and their applicability,resulting in unclear standard application scenarios.Therefore,it is imperative to analyze the development of wind-turbine and wind-farm modeling,along with the relevant standards.This paper presents the methods for wind-turbine modeling,the equivalent model of wind farms based on the general model of wind turbines,and the technical provisions and application scenarios involved in the relevant domestic and international standards.The adaptability of the relevant standards is examined.The results of this study are helpful for advancing wind power generation in China and ensuring the safe and stable operation of large-scale wind power systems. | Cong Wang Yan Li Yiwen Fan Yongning Chi Hongchang Qi Hongzhi Liu | 2022 | Global Energy Interconnection2022，5，2： | 3 |
| 12 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 13 | Tuning the nucleation and decomposition of Li2O_(2) by fluorine-doped carbon vesicles towards high performance Li-O_(2) batteries显示文摘Li-O_(2) batteries provide an attractive and potential strategy for energy conversion and storage with high specific energy densities.However,large over-potential in oxygen evolution reactions (OER) caused by the decomposition obstacles of Li_(2)O_(2) seriously impedes its electrochemical performances.Herein,a novel N,O,S and F co-doping vesicular carbon was prepared by self-template pyrolysis method and used in LiO_(2) battery to tune the nucleation and decomposition of Li_(2)O_(2).The introduction of F in the carbon matrix with suitable content can regulate the adsorption of intermediates,through which the morphology of Li_(2)O_(2) can be controlled to film,favorable to its decomposition in charge process.The cathode based on the optimized F doped carbon vesicle exhibits improved electrochemical performances including a low over-potential,large capacity and a long-term stability.Density functional theory (DFT) results show that F and C in C–F bond hasve a strong interaction to Li and O in Li_(2)O_(2),respectively,which can enhance the transfer of electrons from Li_(2)O_(2) to the carbon matrix to generate hole polaron and thus accelerate the delithiation and decomposition of Li_(2)O_(2).This work provides a new sight into understanding the mechanism of nucleation and decomposition of Li_(2)O_(2) for the development of high-performance Li-O_(2) batteries. | Shiyu Ma Hongchang Yao Zhongjun Li Qingchao Liu | 2022 | Journal of Energy Chemistry2022，31，7： | 2 |
| 14 | SecIngress:An API Gateway Framework to Secure Cloud Applications Based on N-Variant System显示文摘Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation. | Dacheng Zhou Hongchang Chen Guozhen Cheng Weizhen He Lingshu Li | 2021 | China Communications2021，18，8： | 2 |
| 15 | SPINDLY, ERECTA, and Its Ligand STOMAGEN Have a Role in Redox-Mediated Cortex Proliferation in the Arabidopsis Root显示文摘反应的氧种类(ROS ) 对所有生活有机体有害,因此,他们必须被移开保证正常生长和开发。ROS 也正在表明分子,但是到目前为止,很少在植物对 ROS 感觉和发展反应的机制被知道。我们这里报导那氢过氧化物在 Arabidopsis 根和那导致外皮增长细长纤弱(间谍) ,连接 O 的 glucosamine acetyltransferase,由维持细胞的氧化还原作用动态平衡调整外皮增长。我们也发现在充满白氨酸的受体 kinase ERECTA 和它的通常认为的肽 ligand STOMAGEN 的变化在根外皮增长上堵住氢过氧化物的效果。然而,而额外的外皮房间从内皮被生产, ERECTA 和 STOMAGEN 在脉管的织物被表示,建议细胞间的发信号的参与。间谍 ERECTA 显得行动下游,因为间谍变化仍然在 erecta 异种背景引起了外皮增长。我们因此有不仅获得了卓见进由哪个间谍调整根开发的机制而且揭开为在植物发信号的 ROS 的一条新奇小径。对氧化应力的保护的机制也被讨论的调停氧化还原作用的外皮增长的重要性。 | Hongchang Cui Danyu Konga Pengcheng Wei Yueling Hao Keiko U. Torii Jin Suk Lee Jie Li | 2014 | Molecular Plant2014，7，12： | 2 |
| 16 | CFD - DEM simulation of material motion in air-and-screen cleaning device 显示文摘 | Li Hongchang Li Yaoming Gao Fang | 2012 | Computers and Electronics in Agriculture2012，88，： | 1 |
| 17 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 18 | Seephen Comparison of grasshopper (Orthoptera: Acriclidae) ecology on the grasslands of the Asian steppe in inner Mongolia and the great plains of north America显示文摘 | Lockwood A J Li Hongchang Dodd L J | 1994 | Jorunal of Orthoptera Research1994，，2： | 1 |
| 19 | Removal of four kinds of volatile organic compounds mixture in air using silent discharge reactor driven by bipolar pulsed power显示文摘 | WANG Hongchang LI Duan WU Yan | 2009 | Journal of Electrostatics2009，67，： | 1 |
| 20 | Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load显示文摘 | Wei Dong Jiajun Du Hongchang Shen Dongwei Gao Zhenxiang Li Guanghui Wang Xueru Mu Qi Liu | 2010 | Cancer Immunology, Immunotherapy2010，，： | 1 |
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