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| 1 | Prediction of Soil Erosion on Different Underlaying Surface in Construction Period of Xichang to Panzhihua Expressway显示文摘In order to investigate the behavior of soil erosion on the slope of the different underlaying surface during construction,the experiment with natural rainfall on Xichang-Panzhihua high-way was conducted,to quantify the runoff and soil loss. The re-sults show that:① the main type of soil erosion is gully erosion,the amount of soil erosion caused by gully erosion is higher than that by surface erosion. ② The principal factor causing soil ero-sion on the slope of the embankment is individual amount of pre-cipitation,the width of the embankment and rain intensity. ③ The principal factor causing soil erosion on the cutting slope is indi-vidual amount of precipitation,the width of the cutting slope and rain intensity. ④ The principal factor causing soil erosion on the slope of the dumped soil area is individual amount of precipitation,the width of the flat roof and rain intensity. There are well linear relationships between the amount of soil erosion and the principal factor,and their correlation coefficient are 0.935 7-0.999 8. | CHEN Tingfang CUI Peng CHEN Xingchang | 2007 | Wuhan University Journal of Natural Sciences2007，12，4： | 2 |
| 2 | GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice显示文摘GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner. | Roumei Xing Fang Liu Yiqing Yang Xueqin Cui Tongtong Wang Ling Xie Yongliang Zhao Lei Fang Tingfang Yi Biao Zheng Mingyao Liu Huaqing Chen | 2018 | Science China(Life Sciences)2018，61，6： | 1 |
| 3 | Influence of shaped and modified Hβ zeolite on etherification of FCC light gasoline 显示文摘 | Hu Tingfang Chen Jinpeng Wang Haiyan | 2006 | Microporous Mesoporous Materials2006，94，123： | 1 |
| 4 | Influence of shaping condition on etherification performanceof Hβ zeolite 显示文摘 | Hu Tingfang Chen Jinpeng Wang Haiyan | 2006 | Petroleum Science and Technology2006，24，12： | 1 |
| 5 | Advanced nano drug delivery systems for neuroprotection against ischemic stroke显示文摘Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS. | Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
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