|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Cooling mechanism of embankment with block stone interlayer in Qinghai-Tibet railway显示文摘In order to study the cooling mechanism of embankment with block stone interlayer under open and closed conditions,an experimental railway section was built and data within one freeze-thaw cycle were collected. The results explain well the cooling mechanism of embankment with block stone interlayer. Under the open condition in cold seasons,the enforced convection effect occurs within block stone interlayer when the wind speed is large;however,the weak air convection occurs within the block stone interlayer near the bottom of the embankment when the wind speed is slow. Under the open condition in warm seasons,heat conduc-tion occurs within block stone interlayer due to the change in wind speed and di-rection. Under the closed condition,however,the enforced convection within block stone interlayer is so weak that heat conduction is dominant in the whole year be-cause wind is blocked. Therefore,the cooling effect of embankment with a block stone interlayer to the soil beneath it is produced by enforced convection and weak free air convection;both its process and the cooling intensity are controlled by the local wind speed and direction. Because of the difference in the cooling effects,the soil temperature beneath the embankment has a temperature difference of 2℃―4℃ between the open and closed conditions. | WU QingBai CHENG HongBin JIANG GuanLi MA Wei LIU YongZhi | 2007 | Science China(Technological Sciences)2007，50，3： | 8 |
| 3 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 4 | Groundwater evapotranspiration under psammophilous vegetation covers in the Mu Us Sandy Land, northern China显示文摘Groundwater is a significant component of the hydrological cycle in arid and semi-arid areas. Its evapotranspiration is an important part of the water budget because many plants are groundwater-dependent. To restore the degraded ecosystems, the need is pressing to further our understanding of the groundwater evapotranspiration(ET_g) in arid and semi-arid areas. This study employed the White method to estimate ET_g at four sites in the Mu Us Sandy Land in northern China, and the four sites are covered by Salix psammophila(SP site), Artemisia ordosica(AO site), Poplar alba(PA site), and Carex enervis(CE site), respectively. The depth of groundwater table and the duration of drainage were taken into account in calculating the specific yield(S_y) to improve the accuracy of the ET_g estimats. Our results showed that from late May to early November 2013 the ET_g were 361.87(SP site), 372.53(AO site), 597.86(PA site) and 700.76 mm(CE site), respectively. The estimated ET_g rate was also species-dependent and the descending order of the ET_g rate for the four vegetation was: C. enervis, P. alba, A. ordosica, and S. psammophila. In addition, the depth of groundwater table has an obvious effect on the ET_g rate and the effect varied with the vegetation types. Furthermore, the evapotranspiration for the vegetation solely relying on the water supply from unsaturated layers above the groundwater table was much less than that for the vegetation heavily relying on the water supply from shallow aquifers. | CHENG Donghui DUAN Jibo QIAN Kang QI Lijun Yang Hongbin CHEN Xunhong | 2017 | Journal of Arid Land2017，9，1： | 4 |
| 5 | Facile one-step synthesis of Cu_2O@Cu sub-microspheres composites as anode materials for lithium ion batteries显示文摘Cu_2O@Cu sub-microspheres composites with a narrow particle size distribution from 300 to 500 nm was successfully fabricated by one-step synthesis through the direct thermal decomposition of copper nitrate(Cu(NO_3)_2) in octadecylamine(ODA) solvent. As anode materials for lithium ion batteries, the Cu_2 O@Cu composites obviously possess high specific capacity, excellent cyclic stability and rate capability. The coulombic efficiency is about 84% in the 1 st cycle and increases significantly up to 97.8% during successive cycles at various current densities. Even under a high current density of 500 m A g^(-1), the discharge capacity of Cu_2 O@Cu composites remains up to 200 m Ah g^(-1). The excellent electrochemical properties are ascribed to the synergistic effect between high electronic conductivity and volume-buffering capacity of metallic copper composited with Cu_2 O. | Huijie Zhou Hongbin Zhao Xuan Zhang Hongwei Cheng Xionggang Lu Qian Xu | 2018 | Journal of Materials Science & Technology2018，34，7： | 3 |
| 6 | Changes in neuronal apoptosis and apoptosis modulatory factors in cerebral ischemia/reperfusion显示文摘BACKGROUND: The high concentration of glutamate release is the main cause for neuronal cell death. The relationship between glutamate level and apoptosis during ischemia/reperfusion injury is still unclear. OBJECTIVE: To observe the neuronal apoptosis at 24 and 72 hours following cerebral ischemia/reperfusion in rats,and analyze the possible influencing factors. DESIGN: A randomized controlled animal experiment. SETTING: School of Medicine,Southern Yangtze University. MATERIALS: Totally 30 male adult Sprague Dawley (SD) rats of clean grade,weighing 240-290 g,were obtained from Shanghai Experimental Animal Center,Chinese Academy of Sciences. The rats were randomly divided into sham-operated group (n=10) and model group (n=20). Each group was observed at 24 and 72 hours after ischemia/reperfusion,5 rats at each time point in the sham-operated group,whereas 12 at 24 hours and 8 at 72 hours in the model group. Kits for determining apoptosis and Bcl-2 were bought from Wuhan Boster Biological Technology,Co.,Ltd.; Kit for calcineurin from Nanjing Jiancheng Bioengineering Institute. METHODS: The experiment was carried out in the Functional Scientific Research Room of Southern Yangtze University from June to October in 2006. ① Right middle cerebral artery was occluded by inserting a thread through internal carotid artery (ICA). The surgical process for the sham-operated rats was the same as that in the model group except a nylon suture inserted the ICA. According to Longa five-degree standard,the neurological deficit evaluation of rats was evaluated after surgery,and grades 1-3 were taken as successful model establishment. The blood was recirculated by withdrawing the nylon filament under anesthesia at 2 hours after ischemia in successful rat models. ②After reperfusion,the brain tissue was quickly removed at 24 or 72 hours and the slices were obtained from optic chiasma to funnel manubrium. The changes of the number of apoptotic cells were observed using the terminal deoxynucleotidyl transferase mediated dUTP-biotin nick-end labeling method. The expressions of Bcl-2 protein were determined with immunohistochemical staining. The activity of calcineurin was determined by the inorganic phosphorus method. The content of excitatory amino acid was detected by high performance liquid chromatography. MAIN OUTCOME MEASURES: ① Glutanate content in brain tissue; ② Conditions of apoptosis; ③ Calcineurin activity in brain tissue; ④ Bcl-2 expression in brain tissue. RESULTS: Totally 30 SD rats were used,5 died and the other 25 were involved in the analysis of results. ① Changes of apoptosis: There were 0-3 apoptotic cells in the sham-operated group. In the model group,the numbers of apoptotic cells were obviously increased at 24 and 72 hours of reperfusion (P < 0.01),and it was markedly reduced at 72 hours as compared with 24 hours (P < 0.01). ② Changes of glutanate content: The glutamate contents at 24 and 72 hours of reperfusion in the model group were obviously higher than those in the sham-operated group (P < 0.01); In the model group,it was obviously increased at 24 hours as compared with 72 hours (P < 0.01). ③ Changes of Bcl-2 protein: In the model group,the Bcl-2 protein expression had no obvious changes at 24 hours of reperfusion,and it was obviously enhanced at 72 hours,which was obviously different from that in the sham-operated group and that at 24 hours (P < 0.01). ④ Changes of calcinerin activity: In the model group,the activity of calcineurin in brain tissue had no obvious changes at 24 hours of reperfusion; The activity of calcineurin at 72 hours was obviously higher than that in the sham-operated group and that at 24 hours (P < 0.01). CONCLUSION: The brain cyto-apoptosis action at different time points following reperfusion incompletely depends on the glutamate levels,while it depends on the interaction of some apoptosis related factors,such as amino acid,calcineurin,and Bcl-2,etc. | Liying Qiu Ying Li Hongbin Fan Bin Du Zhiyong Yang Jianqing Cheng | 2007 | Neural Regeneration Research2007，2，6： | 3 |
| 7 | A multi-step induced strategy to fabricate core-shell Pt-Ni alloy as symmetric electrocatalysts for overall water splitting显示文摘Devising an electrocatalyst with brilliant efficiency and satisfactory durability for hydrogen production is of considerable demand,especially for large-scale application.Herein,we adopt a multi-step consequential induced strategy to construct a bifunctional electrocatalyst for the overall water splitting.Graphene oxide(GO)was used as a carbon matrix and in situ oxygen source,which was supported by the octahedral PtNi alloy to form the PtxNiy-GO precursor.When calcinating in Ar atmosphere,the oxygen in GO induced the surface segregation of Ni from the PtNi octahedron to form a core-shell structure of Ptx@Niy.Then,the surface-enriched Ni continuously induced the reformation of C in reduced graphene oxide(rGO)to enhance the degree of graphitization.This multi-step induction formed a nanocatalyst Pt_(x)@Ni_(y)-rGO which has very high catalytic efficiency and stability.By optimizing the feeding ratio of PtNi(Pt:Ni=1:2),the electrolytic overall water splitting at 10 mA·cm^(-2) can be driven by an electrolytic voltage of as low as 1.485 V,and hydrogen evolution reaction(HER)only needs an overpotential of 37 mV in 1.0 M KOH aqueous solution.Additionally,the catalyst exhibited consistent existence form in both HER and oxygen evolution reaction(OER),which was verified by switching the anode and cathode of the cell in the electrolysis of water.This work provides a new idea for the synthesis and evaluation of the bifunctional catalysts for water splitting. | Wenjuan Xu Jinfa Chang Yinggang Cheng Hongqi Liu Jifan Li Yongjian Ai Zenan Hu Xinyue Zhang Yiming Wang Qionglin Liang Yang Yang Hongbin Sun | 2022 | Nano Research2022，15，2： | 1 |
| 8 | Fabrication of paper-based devices for in vitro tissue modeling显示文摘Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical applications.The paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional characteristic.The paper-based devices provide precise control over their structures as well as cell distributions,allowing recapitulation of certain interactions between the cells and the extracellular matrix.These features have shown great potential for the development of normal and diseased human tissue models.In this review,we discuss the fabrication of paper-based devices for in vitro tissue modeling,as well as the applications of these devices toward drug screening and personalized medicine.It is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances,such as good biocompatibility,eco-friendliness,cost-effectiveness,and amenability to various biodesign and manufacturing needs. | Hongbin Li Feng Cheng Juan A.Robledo-Lara Junlong Liao Zixuan Wang Yu Shrike Zhang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 9 | A fuzzy clustering algorithm based on evolutionary programming 显示文摘 | Dong Hongbin Dong Yuxin Cheng Zhou | 2009 | Expert Systems with Applications2009，36，11： | 1 |
| 10 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 11 | Cooperative Spectrum Sensing in Cognitive Radio Networks in the Presence of The Primary User Emulation Attack 显示文摘 | Chen Chao Cheng Hongbin Yao Yudong | 2011 | IEEE Transactions on Wireless Communications2011，10，7： | 1 |
| 12 | Development of a simple combining apparatus to perform a magnetic stirring-assisted dispersive liquid-liquid microextraction and its application for the analysis of carbamate and organophosphorus pesticides in tea drinks显示文摘 | WANG Xiuhong CHENG Jing ZHOU Hongbin | 2013 | Analytica Chimica Acta2013，787，13： | 1 |
| 13 | Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury显示文摘 | Sen Wang Hongbin Cheng Guanghui Dai Xiaodong Wang Rongrong Hua Xuebin Liu Peishen Wang Guangming Chen Wu Yue Yihua An | 2013 | Brain Research2013，，： | 1 |
| 14 | Mechanism for dimethylformamide-treatment of poly(3,4-ethylenedioxythiophene) : poly (styrene sulfonate)layer to enhance short circuit current of polymer solarcells 显示文摘 | Gong Cheng Yang Hongbin Song Qunliang | 2012 | Solar Energy Materials & Solar Cells2012，100，： | 1 |
| 15 | Morphology and properties of hollow - fiber membrane made by PAN mixing with small amount of PVDF显示文摘 | Yin Xiuli Cheng Hongbin Wang Xin | 1998 | J Membr Sci1998，149，： | 1 |
| 16 | Morphology and properties of hollow-fiber membrane made by PAN mixing with small amount of PVDF显示文摘 | Yin Xiuli Cheng Hongbin Wang )(in | 1998 | Journal of Membrane Science1998，149，： | 1 |
| 17 | Hydrolysis technology of biomass water to produce amino acids in sub-critical water 显示文摘 | CHENG Hongbin ZHU Xian ZHU Chao | 2008 | Bioresource Technology2008，99，9： | 1 |
| 18 | A fuzzyclustering algorithm based on evolutionary programming显示文摘 | Dong Hongbin Dong Yuxin Zhou Cheng | 2009 | Expert Systems with Applications2009，36，11： | 1 |
| 19 | Diabetes mellitus and incidence and mortality of kidney cancer: A meta-analysis显示文摘 | Cuiping Bao Xilin Yang Weili Xu Hongbin Luo Zhongliang Xu Cheng Su Xiuying Qi | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 20 | A Mathematical Model ofan Oscillating Heat Pipe显示文摘 | Peng Cheng Hongbin Ma | 2011 | Heat Transfer Engineering2011，32，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员