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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Transposition of left renal vein for treatment of the nutcracker phenomenon in long term follow-up显示文摘 | Markus H Ganluca D Christian H | 2002 | Urology2002，59，3： | 1 |
| 3 | Global frequency and distribution of lightning as observedfrom space by the Optical Transient Detector显示文摘 | Christian H J Blakeslee R J Boccippio D J | 2003 | Journalof Geophysical Research2003，108，： | 1 |
| 4 | Iterative wavelet- based denoising methods and robust outlier detection显示文摘 | RADU R VALER1E L D CHRISTIAN H | 2005 | IEEE Signal Processing Letters2005，12，8： | 1 |
| 5 | Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin显示文摘 | Meryl H Claire E Y Christiane M D | 2010 | J Nutr Biochem2010，21，7： | 1 |
| 6 | Sequential injection immunoassay utilizing immunomagnetic beads 显示文摘 | Pollema C H Ruzicka J Christian G D | 1992 | Anal Chem1992，64，： | 1 |
| 7 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 8 | Global frequency and distribution of lightning as observed from space by the optical transient deteetor显示文摘 | CHRISTIAN H J BLAKESLEC R J BOCCIPPIO D J | 2003 | J Geo Res2003，108，1： | 1 |
| 9 | Derivatives of γ- Valerolactone, 1,4-Pentanediol and 1,4-Di-( β-cyanoe- thoxy)-Pentane 显示文摘 | Christian R V Brown H D Hixon R M | 1947 | Journal of the American' Chemical Society1947，69，： | 1 |
| 10 | Modeling and characterization of the 3rd order charge-pump PLL: a fully event-driven approach 显示文摘 | CHRISTIAN D H HACHEM A | 1999 | Analog Integrated Circuits and Signal Processing1999，19，1： | 1 |
| 11 | Niobium and titanium diffusion in the high niobium - contai- ning Ti - 54Al - 10Nb alloy 显示文摘 | SERGIY D FRANK H CHRISTIAN K | 2006 | Intermetallics2006，14，1： | 1 |
| 12 | Bainite in steels 显示文摘 | BHADESHIA H K D H CHRISTIAN J W | 1990 | Metallurgical transactions A1990，21，： | 1 |
| 13 | Adsorption of rrsenic from water using activated neutralized red mud 显示文摘 | Genc-Fuhrman H Christian Tjell J Mcconchie D | 2004 | Environmental Science & Technology2004，38，8： | 1 |
| 14 | Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue 显示文摘 | Warne J P John C D Christian H C | 2006 | Am J Physiol Endocrinol Metab2006，291，6： | 1 |
| 15 | An Improved Optimization Algorithm and a Bayes Factor Termination Criterion for Sequential Projection Pursuit显示文摘 | Bobbie J M Webb-Robertson Kristin H J Scott D H Christian P Bob W W | 2005 | Chemometrics and Intelligence Laboratory Systems2005，77，12： | 1 |
| 16 | Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation 显示文摘 | ANDRE D CHRISTIAN J H CAROLE T | 2007 | Circulation2007，116，： | 1 |
| 17 | BerlinMOD: a benchmark for moving object databases 显示文摘 | CHRISTIAN D THOMAS B RALF H G | 2009 | The VLDB Journal2009，，18： | 1 |
| 18 | Gene expression during cold acclimation in strawberry显示文摘 | CHRISTIAN N D FRANCOIS O MARIO H | 1997 | Plant Cell Physiology1997，38，7： | 1 |
| 19 | Global frequency and distribution of lightning as observed from space by the optical transient detector显示文摘 | Christian H J Blakeslee R J Boccippio D J | 2003 | Journal of Geophysical Research2003，114，1： | 1 |
| 20 | Imaging findings of cochlear nerve deficiency 显示文摘 | Christine MG Christian D Ric H | 2002 | AJNR2002，23，4： | 1 |
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