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| 1 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | 纳米技术:基于相关指标及统计数据的述评(Ⅱ)显示文摘3 纳米技术应用领域及机构分析3.1概述研究及分析人员认为,纳米技术可能发展为下一代通用技术,这意味着纳米技术将很可能迅速发展成为在各应用领域及产业广泛应用的技术㈣。其主要依据是纳米技术使得在基本原子和分子水平更深入地认识和控制物质成为可能,从而有助于改进几乎所有产业的制造工艺。 | Christopher Palmberg Hélène Dernis Claire Miguet 张树良 | 2011 | 科技导报2011，29，23： | 5 |
| 3 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 5 | Hierarchical Struc- ture and Search in Complex Organizations显示文摘 | JURGEN M CHRISTOPH H L | 2010 | Man- agement Science2010，5，： | 1 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | An hp- adaptive pseudospectral method for solving optimal control problems显示文摘 | CHRISTOPHER L WILLIAM H RAO V | 2011 | Optimal Control Applications and Methods2011，32，4： | 1 |
| 8 | Frequent hypermethyla-tion of RASSF1A tumour suppressor gene promoter and pres- ence of Merkel cell polyomavirus in small ceil lung cancer显示文摘 | Peter H Christoph L Esther H | 2009 | European Journal of Cancer2009，45，： | 1 |
| 9 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 10 | Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys显示文摘 | Christopher L Coe Marian Kramer Boldizsár Czéh Elizabeth Gould Alison J Reeves Clemens Kirschbaum Eberhard Fuchs | 2003 | Biological Psychiatry2003，，10： | 1 |
| 11 | Knowl edge network characteristics and entrepreneurial orienta tion of multinational corporations, research policy显示文摘 | CHRISTOPHER W SOO H L RESOURCE A | 2009 | Re search Policy2009，38，8： | 1 |
| 12 | Shielding effectiveness measurements of materials using nested reverberation chambers 显示文摘 | Christopher L H David A H | 2003 | IEEE Transactions on Electromagnetic Compatibility2003，45，2： | 1 |
| 13 | Developing marketing strategies for transnational service operations 显示文摘 | CHRISTOPHER H L | 1996 | Journal of Services Marketing1996，5，1： | 1 |
| 14 | Temperature and the expression of myogenic regulatory factors(MRFs) and myosin heavy chain isoforms during embryogenesis in the com- mon carp Cyprinus carpin L显示文摘 | Nicholas J Thomas E H Christopher L | 2004 | J Expel Biol2004，207，24： | 1 |
| 15 | Combined Epstein-Barr virus and human papillomavirus infection in nasopharyngeal carcinoma显示文摘 | RASSEKH Peter L | 1998 | Largngoscope1998，108，3： | 1 |
| 16 | Intensive care unit-acquired stenotrophomonas maltophilia:Incidence,risk factors and outcome显示文摘 | Saad N Christophe DP Hélène B | 2006 | Critical Care2006，10，： | 1 |
| 17 | Synthesis,characterization,and catalytic properties of amicroporous/mesoporous material,MMM-1显示文摘 | RAJA H P POLADI R CHRISTOPHER C L | 2002 | J SolidState Chem2002，167，： | 1 |
| 18 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 19 | Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases显示文摘 | Jerzy L Christopher C Michael H | 2008 | Modern Pathology2008，21，4： | 1 |
| 20 | The value of information sharing in a two-level supply chain显示文摘 | So Kut C Tang Christopher S | 2000 | Management Science2000，46，5： | 1 |
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