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| 1 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 2 | MSM and HIV/AIDS in China显示文摘This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk behaviors. In addition, majority of MSM have also experienced sexual encounters with women sometimes in their lives, which possibly con- tribute to spread of HIV to women. Some reports documented that HIV is becoming rampant among MSM since more than 1% of them are now infected. Political, cultural and custom elements could hinder intervention activities against HIV spread among MSM. Fortunately, many cities in China have seen that MSM were in cooperation with responsible institutions carrying out certain intervention measures. The general situation is promising. The authors forecast that the fast HIV spread among MSM of China could possibly be halted within several years when the authorities become more sensible to this issue, health service institutions offer unswerving efforts toward the MSM community and those who involve in MSM undertakes necessary responsibilities. | Bei Chuan ZHANG Quan Sheng CHU | 2005 | Cell Research2005，15，11： | 26 |
| 3 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 4 | LEAFY HEAD2,which encodes a putative RNA-binding protein,regulates shoot development of rice显示文摘在植物的开发期间,更高的植物连续地在常规空间、时间的模式形成新叶子。有反常的叶的异种发展模式不仅提供大卓见进理解植物建筑学的规章的机制,而且充实方法到它庄稼产量能被改进的修正。这里,我们报导了米饭 leafy-head2 (lhd2 ) 的描述展览弄短的异种阶段的 plastochron,侏儒症,减少的 tiller 数字,和失败转移从对繁殖生长植物。而减少的 tiller 数字是 tiller 芽长出的抑制的后果,解剖、组织学的学习表明在 lhd2 的叶子的快速的出现从叶 primordia 的快速的开始被结果。分子、基因的分析证明 LHD2 与 67% 类似编码通常认为的 RNA 有约束力的蛋白质到玉米 TE1。染色体规模表示侧面在之间的比较野类型并且 lhd2 植物建议 LHD2 可以通过 KNOX 和荷尔蒙相关的基因调整米饭射击开发。LHD2 变化和 LHD2 的保存表示模式引起的类似的显型在在草控制时间的叶开始显示了保存机制。 | Guo Sheng Xiong Xing Ming Hu Yong Qing Jiao Yan Chun Yu Cheng Cai Chu Jia Yang Li Qian Qian Yong Hong Wang | 2006 | Cell Research2006，16，3： | 11 |
| 5 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 6 | Safety and feasibility of emergent percutaneous coronary intervention with the transradial access in patients with acute myocardial infarction显示文摘The use of intense anticoagulation and antiplatelettherapy in acute myocardial infarction (AMI)potentially increases the risk of bleeding complicationsduring percutaneous coronary intervention (PCI) via thetransfemoral approach. Recently, the transradial accesshas been increasingly employed as an alternative meansfor diagnostic and interventional procedures. Lowincidence of vascular access site bleeding complicationssuggests the transradial approach as a safe alternative tothe femoral technique in AMI, particularly under anaggressive anticoagulation/antiplatelet regimen.Nevertheless, the safety and feasibility of employing thetransradial approach for primary PCI in AMI has not beenthoroughly investigated so far. | LI Wei-min LI Yue ZHAO Ji-yi DUAN Ya-nan SHENG Li YANG Bao-feng WANG Feng-long GONG Yong-tai YANG Shu-sen ZHOU Li-jun LIU Pei-dong ZHANG Li CHU Shan | 2007 | Chinese Medical Journal2007，，7： | 10 |
| 7 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 8 | Breaking the barriers: advances in acoustic functional materials显示文摘Acoustics is a classical field of study that has witnessed tremendous developments over the past 25 years.Driven by the novel acoustic effects underpinned by phononic crystals with periodic modulation of elastic building blocks in wavelength scale and acoustic metamaterials with localized resonant units in subwavelength scale, researchers in diverse disciplines of physics, mathematics, and engineering have pushed the boundary of possibilities beyond those long held as unbreakable limits. More recently, structure designs guided by the physics of graphene and topological electronic states of matter have further broadened the whole field of acoustic metamaterials by phenomena that reproduce the quantum effects classically. Use of active energy-gain components, directed by the parity–time reversal symmetry principle,has led to some previously unexpected wave characteristics. It is the intention of this review to trace historically these exciting developments, substantiated by brief accounts of the salient milestones. The latter can include, but are not limited to, zero/negative refraction, subwavelength imaging, sound cloaking, total sound absorption, metasurface and phase engineering, Dirac physics and topology-inspired acoustic engineering, non-Hermitian parity–time synthetic active metamaterials, and one-way propagation of sound waves. These developments may underpin the next generation of acoustic materials and devices, and offer new methods for sound manipulation, leading to exciting applications in noise reduction, imaging, sensing and navigation, as well as communications. | Hao Ge Min Yang Chu Ma Ming-Hui Lu Yan-Feng Chen Nicholas Fang Ping Sheng | 2018 | National Science Review2018，5，2： | 7 |
| 9 | Signaling pathways involved in ischemic stroke:molecular mechanisms and therapeutic interventions显示文摘Ischemic stroke is caused primarily by an interruption in cerebral blood flow,which induces severe neural injuries,and is one of the leading causes of death and disability worldwide.Thus,it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the disease.In recent years,efforts have been made to understand the pathophysiology of ischemic stroke,including cellular excitotoxicity,oxidative stress,cell death processes,and neuroinflammation.In the meantime,a plethora of signaling pathways,either detrimental or neuroprotective,are also highly involved in the forementioned pathophysiology.These pathways are closely intertwined and form a complex signaling network.Also,these signaling pathways reveal therapeutic potential,as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic stroke.In this review,we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate in.Therapeutic approaches targeting these signaling pathways,which are associated with the pathophysiology mentioned above,are also discussed.Meanwhile,clinical trials regarding ischemic stroke,which potentially target the pathophysiology and the signaling pathways involved,are summarized in details.Conclusively,this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke,and summarize the therapeutic approaches targeted various pathophysiology,with particular reference to clinical trials and future prospects for treating ischemic stroke. | Chuan Qin Sheng Yang Yun-Hui Chu Hang Zhang Xiao-Wei Pang Lian Chen Luo-Qi Zhou Man Chen Dai-Shi Tian Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 7 |
| 10 | Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation显示文摘背景:Atrial (AF ) 被伴随由在伊朗的银币结构的改变。Calpain 活动在 AF 期间被导致。测试在 calpain 激活之间并且在伊朗的银币的一种原因的关系结构的变化, N-acetyl-Leu-Leu-Met (ALLM ) ,一个 calpain 禁止者,在一个犬的 AF 模型被利用。方法:十五条狗随机被划分成 3 个组:假冒操作组,控制组和 calpain 禁止者组;有 5 条狗的各个。持续 AF 被快速的正确中庭每分钟在 600 敲击踱步 3 个星期导致。ALLM 在 1.0 mg x kg 的剂量被管理(-1) x d (在 calpain 禁止者组的 -1) 。三个星期以后,解朊作用, TnT 和肌浆球蛋白的蛋白质表示, calpain 我本地化和结构的变化在伊朗的银币在左被检验免费的墙,就在伊朗的银币免费的墙和房间中隔分别地。房的尺寸和可收缩的功能被回响心动描记法也测量。结果:长期在在导致的显著结构的变化例如上踱步的伊朗的银币快速在伊朗的银币扩大了体积,肌溶解, TnT 和肌浆球蛋白的降级,在 mitochondrial 的肝糖和变化的累积塑造并且缩放,它是由 calpain 的增加的 paralleled 活动。在 calpain 活动和肌溶解的度之间的积极关联(r = 0.90 961, P <
0.0001 ) 被表明。除了结构的畸形,在伊朗的银币导致步可收缩的机能障碍在这研究被观察。在伊朗的银币导致步收缩性的结构的改变和损失被 calpain 禁止者 ALLM 部分阻止。结论:calpain 的激活向公开结构的改变在前进代表特色。Calpain 禁止者, ALLM,压制了增加的 calpain 活动并且颠倒了结构的改变引起了由在现在的模型在伊朗的银币支撑了纤维性颤动。Calpain 抑制可以因此在 AF 为治疗学的干预提供可能性。 | XUE Hong-jie LI Wei-min LI Yue GONG Yong-tai YANG Bao-feng JIN Cheng-luo SHENG Li CHU Shan ZHANG Li SHAN Hong-bo LIU Jie | 2008 | Chinese Medical Journal2008，，1： | 6 |
| 11 | Production of thick-walled hollow glass microspheres for inertial confinement fusion targets by sol-gel technology显示文摘To fabricate thick-walled hollow glass microspheres(HGMs)for inertial confinement fusion(ICF)targets by sol-gel technology,we investigated the effects of glass composition,blowing agent,refining temperature,pressure and composition of furnace atmosphere on the wall thickness of HGMs by numerical simulation and experiments.The results showed that the residence times of the thick-walled HGMs in the encapsulating and refining phases decreased with the increase of wall thickness of HGMs.As a response to this challenge,glass composition must be optimized with the object of high surface tension and low viscosity at refining temperature,and the blowing agents with high decomposition temperature should be used,furthermore the concentration of blowing agents in gel particles must also be precisely controlled.The higher volume fraction of argon gas in the furnace atmosphere,the thicker the wall of HGMs.Due to the limited operating range of furnace atmosphere pressure,changing furnace atmosphere pressure could not significantly increase the wall thickness of HGMs.Although increasing refining temperature can improve the yield of high quality HGMs,a higher furnace atmosphere temperature may lead to a decrease in the wall thickness of HGMs.When the volume fraction of argon gas in the furnace atmosphere ranged from 80%to 95%,the furnace atmosphere pressure ranged from 1.0×105Pa to 1.25×105 Pa,and the refining temperature ranged from 1600°C to 1800°C,we produced thick-walled(5–10-m)HGMs with good sphericity,wall thickness uniformity and surface finish.However,the yield of high quality HGMs needs to be further improved.The compressive strength,tensile strength and permeation coefficient to deuterium gas of thick-walled HGMs at ambient temperature decreased with increase of the wall thickness. | GAO Cong QI XiaoBo WEI Sheng ZHANG ZhanWen LI Bo SHI Tao CHU QiaoMei | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
| 12 | Multiscale nanowire-microfluidic hybrid strain sensors with high sensitivity and stretchability显示文摘Nanomaterials with low-dimensional morphology have been explored for enhancing the performance of strain sensors,but it remains difficult to achieve high stretchability and sensitivity simultaneously.In this work,a composite structure strain sensor based on nanomaterials and conductive liquid is designed,demonstrated,and engineered.The nanowire-microfluidic hybrid(NMH)strain sensor responds to multiscale strains from 4%to over 400%,with a high sensitivity and durability under small strain.Metal nanowires and carbon nanotubes are used to fabricate the NMH strain sensors,which simultaneously exhibit record-high average gauge factors and stretchability,far better than the conventional nanowire devices.Quantitative modeling of the electrical characteristics reveals that the effective conductivity percolation through the hybrid structures is the key to achieving high gauge factors for multiscale sensing.The sensors can operate at low voltages and are capable of responding to various mechanical deformations.When fixed on human skin,the sensors can monitor large-scale deformations(skeleton motion)and small-scale deformations(facial expressions and pulses).The sensors are also employed in multichannel,interactive electronic system for wireless control of robotics.Such demonstrations indicate the potential of the sensors as wearable detectors for human motion or as bionic ligaments in soft robotics. | Songjia Han Chunrui Liu Huihua Xu Dongyuan Yao Kanghong Yan Huanliang Zheng Hui-Jiuan Chen Xuchun Gui Sheng Chu Chuan Liu | 2018 | npj Flexible Electronics2018，2，1： | 6 |
| 13 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 14 | Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects显示文摘 | Wen-Fang Tian Ping Weng Qiong Sheng Jun-Liang Chen Peng Zhang Ji-Ru Zhang Bin Du Min-Chen Wu Qing-Feng Pang Jian-Jun Chu | 2017 | Chinese Medical Journal2017，，7： | 5 |
| 15 | Prediction of the Mooring Force of a 2-D Floating Oil Storage Tank显示文摘A Constrained Interpolation Profile(CIP)-based model is developed to predict the mooring force of a two- dimensional floating oil storage tank under wave conditions, which is validated against to a newly performed experiment. In the experiment, a box-shaped floating oil storage apparatus is used. Computations are performed by an improved CIP-based Cartesian grid model, in which the THINC/SW scheme(THINC: tangent of hyperbola for interface capturing; SW: Slope Weighting), is used for interface capturing. A multiphase flow solver is adopted to treat the water-air-body interactions. The Immersed Boundary Method(IBM) is implemented to treat the body surface. Main attention is paid to the sum force of mooring line and velocity field around the body. It is found that the sum force of the mooring line increases with increasing wave amplitude. The body suffers from water wave impact and large body motions occur near the free surface. The vortex occurs near the sharp edge, i.e., the sharp bottom corners of the floating oil storage tank and the vortex shedding can be captured by the present numerical model. The present model could be further improved by including turbulence model which is currently under development. Comparison between the computational mooring forces and the measured mooring forces is presented with a reasonable agreement. The developed numerical model can predict the mooring line forces very well. | CHU Xinjie DONG Sheng ZHAO Xizeng | 2014 | Journal of Ocean University of China2014，13，6： | 4 |
| 16 | Template matching for simple waveforms with low signal-to-noise ratio and its application to icequake detection显示文摘Template matching is a useful method to detect seismic events through waveform similarity between two signals.The traditional template matching method works well in detecting small tectonic earthquakes.However,the method has some difficulty when the signals have relatively low signal-to-noise ratios(SNRs)and simple shapes,e.g.a sinusoidal function.In this study,we modify the traditional template matching approach for this situation.We first construct a virtual three-component seismic station using vertical-component waveforms recorded by three stations.Next,we select a template event from the virtual station,and apply the traditional template matching.We then verify this method by detecting icequakes with simple waveforms on the Urumqi Glacier No.1 and compare the results with those from the short-term-averages over long-term-average(STA/LTA),the REST method,and traditional template matching method.It can be concluded that the modified template matching method using virtual stations has some advantages for seismic data with low SNRs. | Haichao Ma Risheng Chu Minhan Sheng Ziye Yu | 2020 | Earthquake Science2020，33，5： | 3 |
| 17 | Poisson's ratios and S-wave velocities of the Xishancun landslide,Sichuan,China,inferred from high-frequency receiver functions of local earthquakes显示文摘Landslides are recurrent geological phenomena on Earth that cause heavy casualties and property losses annually.In this study,we use the V_(p)-k stacking and nonlinear waveform inversion methods of high-frequency receiver functions extracted from local earthquakes,to sequentially invert Poisson’s ratios and S-wave velocities of the Quaternary Xishancun landslide,which is composed of three segments,i.e.,h1,h2,and h3 from bottom to top.Our results show that Poisson’s ratio values are generally higher than 0.33 and that the S-wave velocities vary from 0.1 to 0.9 km s^(-1).High Poisson’s ratios(>0.44)are mainly distributed in the juncture regions between different segments,as well as the western edge of h2.These zones show significant variation in landslide thickness and are potentially hazardous areas.Low velocities of 0.05–0.2 km s^(-1)with thicknesses of 10–30m are widely observed in the lower layer of the landslide.The high Poisson’s ratios and low-velocity layer may be related to water-rich materials in these areas.Our study suggests that the high-frequency receiver functions from local earthquakes can be used to delineate geotechnical structures,which is valuable for landslide stability analysis and hazard mitigation. | Zigen WEI Risheng CHU Zhiwei LI Minhan SHENG Qiu ZENG | 2021 | Science China Earth Sciences2021，64，7： | 3 |
| 18 | M5B3 Boride at the Grain Boundary of a Nickel-based Superalloy显示文摘The grain boundary microstructures of a heat-treated Ni-based cast superalloy IN792 were investigated. The results show that M_5B_3 boride precipitates at the grain boundary. A special orientation relationship between M_5B_3 phase and the matrix at one side of the grain boundary is found. At the same time, two M_5B_3 borides with different orientations could co-exist in a single M_5B_3 particle as an intergrowth besides existing alone, thus forming orientation relationship between the two M_5B_3 phases and matrix. This phenomenon could be attributed to the special orientation relationship between M_5B_3 phase and the matrix. | Beining Du Zhiwu Shi Jinxia Yang Zhaokuang Chu Chuanyong Cui Xiaofeng Sun Liyuan Sheng Yufeng Zheng | 2016 | Journal of Materials Science & Technology2016，32，3： | 2 |
| 19 | Efficiency and safety evaluation of Baimai ointment for alleviating hypermyotonia following cerebral infarction显示文摘BACKGROUND: Baimai ointment has Shujin and Huoluo efficiency. It has been confirmed by basic pharmacodynamic experiments that Baimai ointment has some therapeutic effects on stroke. However,the detailed evaluations of Baimai ointment on clinically treating stroke patients for function recovery are still insufficient with little reports. OBJECTIVE: To observe the efficiency and safety of Baimai ointment on alleviating hypermyotonia following cerebral infarction DESIGN: A randomized,parallel and controlled experiment. SETTING: Department of Neurology,Beijing Aerospace General Hospital. PARTICIPANTS: A total of 120 patients with acute front-cycle cerebral infarction were selected from Department of Neurology,Beijing Aerospace General Hospital from July to December 2006 and met the diagnosis criteria modified by Forth National Seminar on Cerebrovascular Disease. The experiment had got confirmed consent from local ethic committee. All 120 patients with cerebral infarction were randomly divided into experimental group (n =80; 32 in the acute phase,32 in the recovery phase and 16 in the sequela phase) and control group (n =40; 16 in the acute phase,16 in the recovery phase and 8 in the sequela phase). METHODS: Within 4 weeks after the patients were enrolled in this study,no other traditional Chinese medicines containing similar components were adopted besides routine supporting therapy. The Baimai ointment being consisted of Jianghuang,Roudoukou,Gansong,Yangqishi,Gancao,She,shannai,Zanghuixiang,Zangchangpu,Huajiao and Jianhua was used by trial group (20 g/ampoule,Tibet Lingzhiqizheng Tibetan Drug Factory; batch number: 050403),2–3 times per day,the ointment was moderately coated traveling parts of Baimai. MAIN OUTCOME MEASURES: The evaluation of National Institutes of Health Stroke Scale (NIHSS),Modified Rankin Scale and Modified Ashworth Scale were performed before administration,2 and 4 weeks after administration. RESULTS: All 120 patients with acute front-cycle cerebral infarction were involved in the final analysis. ① Evaluation of therapeutic effects: After 4 weeks,the comparison of overall muscular tension and muscular tension in acute phase between the two groups (acute phase,chronic phase and recovery phase) demonstrated that the experimental group improved significantly (Z =–2.25,–2.06,P < 0.05). After 2 weeks,the change of muscular tension was not significantly different from baseline (P > 0.05). Whereas after 4 weeks,the change of muscular tension in acute phase was significantly different from baseline (P < 0.05); however,the change of muscular tension in recovery phase and sequelae phase was not significantly different from baseline (P > 0.05). After the treatment,the overall NIHSS and disability score of both groups did not change significantly (P > 0.05). ② Adverse reaction and side effect: There were two adverse events in experimental groups. One patient underwent petechia,and the symptom disappeared following stopping medication which did not reappear after remedication. The other patient complained of a pain coming from the place where the medication was used,and the symptom went away without treatment. Two cases of adverse events were not significantly correlated with the usage of medication,so both of which could not be confirmed to be adverse reactions. CONCLUSION: Baimai ointment achieves some therapeutic effects on treating hypermyotonia of cerebral infarction patients,especially significantly preventing the hypermyotonia in acute phase with good safety. | Sheng da Liu Chu ming Jiang Dong hua Li Cui peng Xie Jian xin Yan | 2007 | Neural Regeneration Research2007，2，10： | 2 |
| 20 | Pyrolysis of single large biomass particle: Simulation and experiments显示文摘Pyrolysis and heat transfer characteristics of single large biomass particle were investigated using threedimensional unsteady heat transfer model coupled with chemical reactions.The consumption of biomass and the production of products were simulated.Some experiments were designed to provide model parameters for simulation calculations.The simulation was verified by pyrolysis experiments of large biomass particle in a vertical tube furnace.The simulation results show the internal heat and mass transfer law during the pyrolysis of large biomass particle.When the biomass particle diameter is between 10 and 30 mm,for every 5 mm increase in particle diameter,the time required for complete pyrolysis will increase on average by about 50 s.When the pyrolysis temperature is between 673 K and 873 K,a slight decrease in the pyrolysis temperature will cause the time required for the biomass to fully pyrolyze to rise significantly.And the phenomenon is more obvious in the low temperature range.The results indicate that the numerical simulation agrees well with the experimental results. | Kai Wang Huiyan Zhang Sheng Chu Zhenting Zha | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 2 |
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