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| 1 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 2 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 3 | Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection显示文摘 | Arie Regev Mariana Berho Lennox J Jeffers Clara Milikowski Enrique G Molina Nikolaos T Pyrsopoulos Zheng-Zhou Feng K.Rajender Reddy Eugene R Schiff | 2002 | The American Journal of Gastroenterology2002，，10： | 7 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 6 | The FIF0 -ATPase of Bifidobacterium animalis is involved in bile tolerance显示文摘 | Borja Senchez Clara G de los Reyes-Gavilen Abelardo Margolles | 2006 | Environmental Microbiology2006，8，10： | 1 |
| 7 | Development of self-assembled bacterial cellulose-starch nanocomposites 显示文摘 | Cristian J Grande Fernando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 8 | Cost and benefit analysis of routine varicella vaccination in German Children 显示文摘 | Beutels P Clara G Tormans E | 1996 | JID1996，174，3： | 1 |
| 9 | Identification of relevant micropollutants in Austrian municipal wastewater and their behaviour during wastewater treatment显示文摘 | CLARA M WINDHOFER G WEILGONY P | 2012 | Chemosphere2012，87，11： | 1 |
| 10 | Development of self-assembled bacterial cellulose-starch nanocomposites显示文摘 | Cristian J Grande Femando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 11 | Computer vision face tracking for use in a perceptual user interface显示文摘 | BRADSKI G R CLARA S | 1998 | Intelligence Technology Journal1998，2，1： | 1 |
| 12 | Influence of Livestock Soil Eutrophication on Floral Composition in the Pyrenees Mountains显示文摘Livestock behaviour in the Pyrenees includes free grazing and a long resting period that provokes the accumulation of dung and urine in some places,so-called camping areas. The aims of this study were (i) to analyze any change in floral composition,and in nutritional and chemical contents of plants in a livestock camping area; and (ii) to relate the floral composition with soil chemical properties. In a linear transect,five sampling zones were established,from the centre of the camping area to the surrounding Nardus stricta-dominant pasture. The above ground plant biomass and the topsoil were sampled in each zone with 6 replicates per zone. Plant species were classified and weighed to calculate above ground biomass,nutritional and chemical contents,and Shannon diversity and evenness indices. Additionally,soils were sampled in two periods,at the beginning and at the end of grazing period. Soil available nutrients (nitrate,ammonium,phosphorus,potassium,calcium and magnesium),total nitrogen,organic carbon and pH were measured. Plant chemical contents (protein,lignin and others) were significantly related to the proportions of grasses,legumes and other plants; so,the protein content is positively correlated with legumes plant biomass while lignin content is negatively correlated with grasses. Both plant and soil nutrients increased linearly towards the centre of the camping area. However,the relationship among plant species richness,diversity and evenness relative to its position along the studied transect was bell-shaped. From the outskirts to the centre of the camping area,plants with low nutrient demand were progressively replaced by those with medium and high nutrients demand and by pioneers. Nardus stricta-dominant pasture has low plant diversity and plant nutrient content as well as a poor soil nutrient availability. The presence of the camping area introduced patches with more soil nutrients and new species in the large spatial scale. However at a small spatial scale,the strong soil nutrient concentration into the centre of the camping area reduced floral composition again. To ensure positive effects of camping areas on plant diversity,and to manage more effectively the nutrients returned to the soil,a reduction in the stocking rate should be pursued. | BADíA David MARTí Clara SáNCHEZ José Ramón FILLAT Federico AGUIRRE Javier GóMEZ Daniel | 2008 | Journal of Mountain Science2008，5，1： | 1 |
| 13 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 14 | A novel cell-based microfluidic multichannel setup-impact of hydrodynamics and surface characteristics on the bioadhesion of polystyrene micro- spheres 显示文摘 | WANG X Y CLARA P FRANZ G | 2013 | Colloids and Surfaces B: Biointerfaces2013，102，： | 1 |
| 15 | Computer vision face tracking for use in a perceptual user interface 显示文摘 | Bradski G R Clara S | 1998 | Intd Technology Journal1998，2，： | 1 |
| 16 | Occurrence of phthalates in surface runoff,untreated and treated wastewater and fate during wastewater treatment显示文摘 | Clara M Windhofer G Hartl W | 2010 | Chemosphere2010，78，9： | 1 |
| 17 | A new black fly isolate of Bacillus thuringiensis autoagglutinating strain highly toxic to Simulium pertinax 显示文摘 | Clara F G Rodrigo N F | 2005 | Mem Inst OswaldoCruz2005，100，7： | 1 |
| 18 | Laboratory studies for light- oil air injection projects: potential application in Handil Field显示文摘 | Clara C Durandeau M Quenault G | 2000 | SPE Reservoir Evaluation & Engineering2000，3，3： | 1 |
| 19 | Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection显示文摘 | Arie Regev Mariana Berho Lennox J Jeffers Clara Milikowski Enrique G Molina Nikolaos T Pyrsopoulos Zheng-Zhou Feng K.Rajender Reddy Eugene R Schiff | 2002 | The American Journal of Gastroenterology2002，，10： | 1 |
| 20 | Computer vision face tracking for use in a perceptual user interface显示文摘 | BRADSKI G R CLARA S | 1998 | Intelligence Technology Journal1998，2，： | 1 |
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