6篇
您的检索式：作者名="CONG Peihong"
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| 1 | Morphology and microstructure of polyamide 46 wear debris and transfer film : In relation to wear mechanisms 显示文摘 | Cong Peihong Xiang Fei Liu Xujun | 2008 | Wear2008，265，78： | 1 |
| 2 | Tribophysical and tribochemical effects of a thermoplastic polyimide 显示文摘 | LI Tongsheng CONG Peihong LIU Xujun | 2000 | Journal of Materials Science2000，35，： | 1 |
| 3 | Effect of crystalline form on the tribological properties of PA46/HDPE polyblends 显示文摘 | Peihong Cong Fei Xiang Xujun Liu | 2008 | Wear2008，265，7： | 1 |
| 4 | Effect of gas pressure on tribological properties and tribochemical reactions of alumina sliding against zirconia in HFC-134a显示文摘 | CONG Peihong IMAI Jun SHIGEYUKI Mori | 2001 | Wear2001，249，： | 1 |
| 5 | The role of products of tribochemical reactions on the friction and wear properties of alumina/silicon carbide couple sliding in HFC-134a gas显示文摘 | Peihong Cong Kimihire Kobaynshi Tongsheng Li | 2002 | Wear2002，252，： | 1 |
| 6 | Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β显示文摘The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported to play an essential role in integrating phosphoinositide trafficking and lipid metabolism in diverse cellular processes but remains unexplored as a potential target for cancer treatment.Herein,data analysis of clinical cancer samples revealed that PITPα/βexpression is closely correlated with the poor prognosis.Target identification by chemical proteomic methods revealed that microcolin H,a naturally occurring marine lipopeptide,directly binds PITPα/βand displays antiproliferative activity on different types of tumour cell lines.Furthermore,we identified that microcolin H treatment increased the conversion of LC3I to LC3II,accompanied by a reduction of the level of p62 in cancer cells,leading to autophagic cell death.Moreover,microcolin H showed preeminent antitumour efficacy in nude mouse subcutaneous tumour models with low toxicity.Our discoveries revealed that by targeting PITPα/β,microcolin H induced autophagic cell death in tumours with efficient anti-proliferating activity,which sheds light on PITPα/βas a promising therapeutic target for cancer treatment. | Hange Yang Xiaowei Zhang Cong Wang Hailong Zhang Juan Yi Kun Wang Yanzhe Hou Peihong Ji Xiaojie Jin Chenghao Li Min Zhang Shan Huang Haoyuan Jia Kuan Hu Lingyun Mou Rui Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
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