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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Diabetes care, glycemic control, and complications in children with type 1 diabetes from Asia and the Western Pacific Region显示文摘 | Craig ME Jones T W Silink M | 2007 | J Diabetes and Its Complications2007，21，5： | 1 |
| 5 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 6 | Automatically utilizing secondary source to align information across sources显示文摘 | Martin M Snehal T Craig A K | 2005 | AI Magazine Spe cial Issue on Semantic Integration2005，26，1： | 1 |
| 7 | Remotely-sensed data as information source for geographical information systems in natural resource management:a review显示文摘 | CRAIG M T | 1991 | International Journal of Geographical Information System1991，5，2： | 1 |
| 8 | Micromechanical adhesion force measurements between tetrahydrofuran hydrate particles显示文摘 | Craig J T Laura E D Kelly T M | 2007 | Journal of Colloid and Interface Science2007，306，： | 1 |
| 9 | Effects of estrogen therapy on age-related differences in gray matter concentration显示文摘 | Robertson D Craig M Van Amelsvoort T | 2009 | Climacteric2009，12，4： | 1 |
| 10 | The great disruption 显示文摘 | Christensen C M Craig T Hart S L | 2001 | Foreign Policy2001，80，2： | 1 |
| 11 | Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury显示文摘 | CRAIG T R DUFFY M J SHYAMSUNDAR M | 2010 | Crit Care Med2010，38，1： | 1 |
| 12 | Does the private sector help or hurt the environment? Evidence from carbon dioxide pollution in developing countries 显示文摘 | Debabrata T Craig M | 2001 | World Development2001，29，1： | 1 |
| 13 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 14 | A review of the clini cal toleration studies of polydextrose in food显示文摘 | Flood M T Auerbaeh M H Craig S A S | 2004 | Food and Chemical Toxicology2004，42，9： | 1 |
| 15 | Electrolyte composition for Cu electrochemical mechanical planarization 显示文摘 | ABHINAV T CRAIG B IAN I S LI Y Z FRANCOIS D ALEX B JAMES M A | 2008 | Journal of The Electrochemical Society2008，155，7： | 1 |
| 16 | Nonlinear dynamics and structural change in the US hog--corn cycle: a time-varying STAR ap- proach显示文摘 | HOLT M T CRAIG L A | 2006 | American Journal of Agricultural Economics2006，88，1： | 1 |
| 17 | Whole-genome analysis of sporadic amyotrophic lateral sclerosis显示文摘 | Dunckley T Huentelman M J Craig DW | 2007 | N Engl J Med2007，357，： | 1 |
| 18 | Does the private sector help or hurt the environment? evidence from carbon dioxide pollution in developing countries 显示文摘 | DEBABRATA T CRAIG M M | 2001 | World Development2001，，29： | 1 |
| 19 | On the status of the serranid fish genus Epinephelus:evidence for paraphyly based upon 16S DNA sequence显示文摘 | Craig M T Pondella D J Franck J P C | 2001 | Mol Phylogenet Evol2001，19，1： | 1 |
| 20 | Immunology of Echinococcus granulosus infections显示文摘 | Rogan M T Craig P S | 1997 | Acta Tropic a1997，，67： | 1 |
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