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| 1 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 2 | The effect of conical flowfields on the performance of waveriders at Mach 6显示文摘The performance of 23 kinds of waveriders, derived from different conical flowfields, is analyzed by the numerical computation under the conditions of fight speed of Mach 6, attack angle of 0° and flight alti- tude of 30 km. These results indicate that the performance is influenced by the shapes and the width to height ratios (W/H ) of generating cones. The geometrical parameter and the lift coefficient are propor- tional to W/H, while the drag coefficient and the lift to drag ratio (L/D ) have extreme values. Considering the base drag and the computation errors, the waverider with the highest L/D is cut from the elliptical cone’s flowfield (W/H = 1.5―1.618), and the configuration with the lowest drag can also be obtained at W/H = 1:1.5. Accordingly, good suggestions are proposed for practical design based on these compu- tational results. | CUI Kai YANG GuoWei | 2007 | Chinese Science Bulletin2007，52，1： | 11 |
| 3 | Waverider configurations derived from general conical flowfields显示文摘基于计算液体,动力学(CFD ) 为灵活 waverider 的设计被介绍的一个方法。这个方法的产生身体能是任何锥。另外,当 waverider 的定义曲线,由二次曲面的功能的 parameterized, S 字形的功能或 B 花键工作,前缘或超音速冲压式喷气发动机的入口的侧面被使用。而且,几个数字例子被执行验证方法和相关代码。配置的 CFD 结果证明所有图案是成功的。而且,主要建议被在马赫 6 点比较导出锥的波浪骑手的几何、空气动力学的表演为实际设计建议。 | Kai Cui Dongxu Zhao Guowei Yang | 2007 | Acta Mechanica Sinica2007，23，3： | 10 |
| 4 | COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response显示文摘It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance.Our genome-wide transcriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clockassociated evening genes PRR5,ELF4 and cold-responsive genes.Chromatin immunoprecipitation indicated that CCA1 is recruited to the site containing EE elements of COR27 and COR28 promoters in a temperaturedependent way.Further genetic analysis shows COR28 is essential for the circadian function of PRR9 and PRR7.Together,our results support a role of COR27 and COR28 as nighttime repressors integrating circadian clock and plant cold stress responses. | peng wang xuan cui chunsheng zhao liyan shi guowei zhang fenglong sun xiaofeng cao li yuan qiguang xie xiaodong xu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 6 |
| 5 | Aerodynamic optimization and evaluation for the three-dimensional afterbody/nozzle integrated configuration of hypersonic vehicles显示文摘The optimization of 2D expansion lines and key parameters of three-dimensional configurations was carried out under simulated conditions of Mach 6.5 and a flight altitude of 25 km for an integrated configuration of the afterbody/nozzle of a hypersonic vehicle.First,the cubic B-spline method was applied to parameterize the expansion lines of the upper expansion ramp.The optimization procedure was established based on computational fluid dynamics and the sequential quadratic programming method.The local mesh reconstruction technique was applied to improve computational efficiency.A three-dimensional integrated configuration afterbody/nozzle was designed based on the two-dimensional optimized expansion lines.The influence rules incorporated certain key design parameters affecting the lift and thrust performance of the configuration,such as the ratio of the lengths of the lower expansion ramp to the afterbody (l/L),the dip angle of the lower expansion ramp ω,and the ratio of exit height to the length of afterbody (H/L).Under these conditions,we found that the integrated configuration has optimal performance when l/L=1/6,H/L=0.35 and =10°.We also showed that the presence of a side-board promotes lift and thrust performance,and effectively prevents the leakage of high pressure gas. | GAO TaiYuan CUI Kai WANG XiuPing HU ShouChao YANG GuoWei REN Liang | 2012 | Chinese Science Bulletin2012，57，8： | 4 |
| 6 | Alkali-activation reactivity of chemosynthetic Al_2O_3-2SiO_2 powders and their ^(27)Al and ^(29)Si magic-angle spinning nuclear magnetic resonance spectra显示文摘Pure Al_2O_3-2SiO_2 powders were prepared by sol-gel and coprecipitation methods,and their alkaliactivation reactivities were compared.The alkali-activation reactivity of the powder prepared by the sol-gel method was higher than that of the powder prepared by the coprecipitation method.The powders were investigated by ^(27)AI and ^(29)Si magic-angle spinning nuclear magnetic resonance spectroscopy(MAS NMR) to understand the relationship between their structure and alkali-activation reactivity.The ^(27)Al MAS NMR data showed that the five-coordinate AI content of the powder prepared by the sol-gel method was higher than that of the powder prepared by coprecipitation.The higher content of five-coordinate Al corresponded to higher alkali-activation reactivity.The ^(29)Si MAS NMR data showed that for the powder prepared by the sol-gel method,silicon was replaced by aluminum at secondary coordination sites of the central Si atoms during calcination.However,for the powder prepared by single-batch coprecipitation,the main change was from a low degree of polycondensation to a high degree of polycondensation. | Guangjian Zheng Xuemin Cui Dong Huang Jinying Pang Guowei Mo Shujuan Yu Zhangfa Tong | 2015 | Particuology2015，13，5： | 3 |
| 7 | Anodic dissolution mechanism of TA15 titanium alloy during counter-rotating electrochemical machining显示文摘Counter-rotating electrochemical machining(CRECM)is a novel shaping method with advantages in processing revolving parts,especially engine casings.However,few researchers have studied the anodic behaviour of the counter-rotating state.This paper aims to analyse the anode dissolution behaviour of TA15 and obtain desired surface qualities in CRECM.The anodic characteristics were measured by polarization and cyclic voltammetry curves,and the passive-trans passive behaviour of TA15 was revealed.The electrode surface structures at different stages were analysed using electrochemical impedance spectroscopy(EIS),and a quantitative dissolution model was established to illustrate the electrochemical dissolution and structural evolution of the revolving surfaces.A series of CRECM experiments were conducted,and three stages(pitting corrosion,pitting expansion,and smoothing)were detected according to the current signals.In the first stage,an oxide film with small pores was formed initially on the metal surface when exposed to air.This air-formed oxide film was broken down locally during the electrochemical reaction process,resulting in the occurrence of pitting.With the increase of electricity,the oxide layer became thinner,and the pitting areas expanded and began to connect with each other.In this stage,the surface quality was poor owing to the uneven material dissolution.When the amount of electricity approximately reached a constant,the oxide layer was completely removed,and a very thin salt film was generated at the metal-electrolyte interface.In this stage,the material was dissolved uniformly,and the surface was smooth without pitting corrosion.Based on the obtained results,anode workpieces with grid-like convex structures were fabricated using CRECM.Both the revolving surface and the sidewalls of the convex structures can be controlled from pitting to smoothness. | CAO WenJian WANG DengYong CUI GuoWei ZHU Di | 2022 | Science China(Technological Sciences)2022，65，6： | 1 |
| 8 | Response surface technique for static aeroelastic optimization on a high-aspect-ratio wing显示文摘 | Yang Guowei Chert Dawei Cui Kai | 2009 | Journal of Aircrait2009，46，4： | 1 |
| 9 | Localized FCM Clustering with Spatial Information for Medical Image Segmentation and Bias Field Estimation显示文摘 | Wenchao Cui Yi Wang Yangyu Fan Yan Feng Tao Lei Guowei Wei | 2013 | International Journal of Biomedical Imaging2013，，： | 1 |
| 10 | Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: A microarray analysis显示文摘 | Jue Cui Guowei Le Ruili Yang Yonghui Shi | 2009 | Cellular Immunology2009，，1： | 1 |
| 11 | Sn-decorated CeO_(2) with different morphologies for direct dehydrogenation of ethylbenzene显示文摘Three Sn-decorated ceria catalysts with various morphologies(rods,particles,and cubes)were prepared and applied to the direct dehydrogenation of ethylbenzene.Multi-technology characterizations,including X-ray photoelectro n spectroscopy(XPS),H_(2)-tempe rature programmed reduction(H_(2)-TPR),and Raman spectroscopy,prove that the oxygen vacancies are the active sites for ethylbenzene dehydrogenation,which can be regulated by engineering CeO_(2) morphology and enhanced via introducing metal Sn.Given the results of activity test,the catalytic activities for ethylbenzene dehydrogenation over different samples are closely dependent on the amount of oxygen vacancies.The reduced Sn-decorated CeO_(2) catalyst with nanoparticles morphology exhibits better dehydrogenation performance than the other two studied catalysts at 600℃.This work provides an effective approach to regulate the active oxygen vacancies and further enhance the dehydrogenation activities through engineering the surface morphology of the catalyst and introducing suitable additives. | Kai Zhang Guoju Cui Mengzhen Yuan Huiwen Huang Ning Li Jiale Xu Guowei Wang Chunyi Li | 2024 | Journal of Rare Earths2024，42，1： | 0 |
| 12 | Biomaterial-assisted photoimmunotherapy for synergistic suppression of cancer progression显示文摘Photoimmunotherapy is an emerging treatment modality that uses photothermal,photodynamic and photochemical processes to fight against cancer by eliciting a robust host immune response.Recently,various nanoformulations of biomaterials have been rationally designed as highly effective photosensitive agents,immunoadjuvants or carriers to enhance phototherapeutic efficacy,boost immune stimulation,amplify nano-permeability and monitor cancer progression in situ.Nevertheless,relying solely on a single-modality therapy may not completely ablate primary tumors,and the metastasis and recurrence of tumors remain a serious challenge.To solve this issue,the strategy of combining photoimmunotherapy with other immunotherapies,such as immune checkpoint blockade,chimeric antigen receptor-T cell or cytokine therapy,can greatly enhance the effectiveness of oncology treatment and reduce the traditional adverse effects.Thus,it is very valuable to summarize the research progress in biomaterial-assisted combination photoimmunotherapy for clinical translation.In this review,the recent advances in constructing multifunctional nano-biomaterials for combinatorial photoimmunotherapy of cancer are summarized.Furthermore,the opportunities,challenges,future trends and prospects in this field are also analyzed to pave the way for advancing the next generation of clinical cancer management strategies. | Yanan Li Jing Cui Chenlong Li Caiting Deng Guowei Deng Hui Zhang Feifei An | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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