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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 3 | RELIABILITY INDICES OF DISCRETE-TIME Geo^X/G/1 QUEUEING SYSTEM WITH UNRELIABLE SERVICE STATION AND MULTIPLE ADAPTIVE DELAYED VACATIONS显示文摘这篇论文从可靠性研究的观点与不可靠的加油站和多重适应推迟的假期认为排队的分离时间的 GeoX/G/1 是模型。后面的问题将被讨论:1 ) 服务者在在时间 n 的一个概括忙时期的概率;2 ) 加油站在在时间 n 的失败的概率,即,加油站的短暂 unavailability,和加油站的稳定的州的 unavailability;3 ) 加油站失败的期望的数字在时间间隔期间(0, n ] ,并且加油站的稳定的州的失败频率;4 ) 加油站故障在的期望的数字一概括的服务者忙碌时期。最后,作者证明有不可靠的加油站的一些普通分离时间的排队模型是在这篇论文讨论的模型的特殊情况。 | Yinghui TANG Miaomiao YU Xi YUN Shujuan HUANG | 2012 | Journal of Systems Science & Complexity2012，25，6： | 8 |
| 4 | De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment显示文摘Intratumoral hypoxia extremely limits the clinic applications of photodynamic therapy(PDT).Endoperoxides allow thermally releasing singlet oxygen(1O_(2))in a defned quantity and ofer promising opportunities for oxygen-independent PDT treatment of hypoxic tumors.However,previous composite systems by combining endoperoxides with photothermal reagents may result in unpredicted side efects and potential harmful impacts during therapy in vivo.Herein,we de novo design an all-in-one polymer carrier,which can photothermally release 1O_(2).Te strategy has been demonstrated to efectively enhance the production of 1O_(2) and realize the photodamage in vitro,especially in hypoxic environment.Additionally,the polymer carrier accumulates into tumor afer intravenous injection via the enhanced permeation and retention efects and accelerates the oxygen-independent generation of 1O_(2) in tumors.Te oxidative damage results in good inhibitory efect on tumor growth.Realization of the strategy in vivo paves a new way to construct photothermal-triggered oxygen-independent therapeutic platform for clinical applications. | Tianci Huang Menglong Zhao Qi Yu Zheng Feng Mingjuan Xie Shujuan Liu Kenneth Yin Zhang Qiang Zhao Wei Huang | 2019 | Research2019，，1： | 6 |
| 5 | FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma显示文摘Objective: Growing evidence indicates that FAT atypical cadherin 1(FAT1) has aberrant genetic alterations and exhibits potential tumor suppressive function in esophageal squamous cell carcinoma(ESCC). However, the role of FAT1 in ESCC tumorigenesis remains not well elucidated. The aim of this study was to further investigate genetic alterations and biological functions of FAT1, as well as to explore its transcriptional regulation and downstream targets in ESCC.Methods: The mutations of FAT1 in ESCC were achieved by analyzing a combined study from seven published genomic data, while the copy number variants of FAT1 were obtained from an analysis of our previous data as well as of The Cancer Genome Atlas(TCGA) and Cancer Cell Line Encyclopedia(CCLE) databases using the cBioPortal. The transcriptional regulation of FAT1 expression was investigated by chromatin immunoprecipitation(ChIP) and the luciferase reporter assays. In-cell western, Western blot and reverse transcription-quantitative polymerase chain reaction(RT-qPCR) were used to assess the indicated gene expression. In addition, colony formation and Transwell migration/invasion assays were employed to test cell proliferation, migration and invasion.Finally, RNA sequencing was used to study the transcriptomes.Results: FAT1 was frequently mutated in ESCC and was deleted in multiple cancers. Furthermore, the transcription factor E2 F1 occupied the promoter region of FAT1, and depletion of E2 F1 led to a decrease in transcription activity and mRNA levels of FAT1. Moreover, we found that knockdown of FAT1 promoted KYSE30 and KYSE150 cell proliferation, migration and invasion;while overexpression of FAT1 inhibited KYSE30 and KYSE410 cell proliferation, migration and invasion. In addition, knockdown of FAT1 led to enrichment of the mitogen-activated protein kinase(MAPK) signaling pathway and cell adhesion process.Conclusions: Our data provided evidence for the tumor suppressive function of FAT1 in ESCC cells and elucidated the transcriptional regulation of FAT1 by E2 F1, which may facilitate the understanding of molecular mechanisms of the progression of ESCC. | Yu Wang Guangchao Wang Yunping Ma Jinglei Teng Yan Wang Yongping Cui Yan Dong Shujuan Shao Qimin Zhan Xuefeng Liu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 6 |
| 6 | Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene显示文摘Dipentaerythritol(DPER),4,40-diphenylmethanediisocyanate(MDI)and melamine(MEL)are used as raw materials to microencapsulate ammonium polyphosphate(MAPP)in situ polymerization.The MAPP is characterized by Fourier transform infrared(FT-IR),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and thermal gravimetric analysis(TGA).The results show that the coating operation can effectively improve water resistance of ammonium polyphosphate(APP),and MAPP has higher residual rate than that of APP after combustion.The flame retardant action of MAPP and APP in polypropylene(PP)is investigated by the limited oxygen index(LOI),vertical burning test(UL-94),TGA,SEM,and cone calorimeter test(CCT).The LOI value of the PP/MAPP composite at the same loading is higher than that of PP/APP composite.UL 94 ratings of PP/MAPP composites are raised to V-0 at 20 wt%loading.The results of CCT also show that MAPP is more efficient than APP.The morphological structures observed by digital photos and SEM demonstrated that MAPP could be promoted to form the continuous and compact intumescent char layer.The flame retardant mechanism of PP/MAPP is also discussed. | Shouwu Yu Shujuan Xiao Zewen Zhao Xiaowen Huo Junfu Wei | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 6 |
| 7 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 8 | Design and synthesis of Al-MOF/PPSU mixed matrix membrane with pollution resistance显示文摘To enhance the performance of the polyphenylene sulfone(PPSU) membrane,a novel mixed matrix membrane with hydrophilicity and antifouling properties was prepared.Using PPSU as the ba sic membrane material,polyvinyl pyrrolidone(PVP) as the porogen,N-Methyl pyrrolidone(NMP) as the solvent,and MOF-CAU-1(Al_(4)(OH)_(2)(OCH_(3))_4(H_2 N-BDC)_(3)·xH_(2) O) as the filler,PPSU/CAU-1 mixed matrix membrane(MMM) was prepared by an immersion precipitation and phase transformation technique.By changing the amount of MOF-CAU-1,the properties and performance of the MMM membrane were investigated in terms of hydrophilicity,pore morphology,surface roughness,and dye removal.The results show that the highest pure water flux of the mixed reached 47.9 L·m^(-2)·h^(-1), when the CAU-1 addition amount was 1.0 wt%, which was 23% higher than that of the pure PPSU membrane.Both the rejection rate and the antifouling performance of the MMM membrane also noticeably improved. | Shujuan Xiao Xiaowen Huo Shuxin Fan Kui Zhao Shouwu Yu Xiaoyao Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 5 |
| 9 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 10 | Construction of Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with multiple hetero-interfaces for enhanced electromagnetic wave absorption显示文摘Nanocomposites with heterogeneous structures and magneto-electric synergistic losses have broad prospects for improving electromagnetic wave(EMW)absorption performance.In this study,we synthesized Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with abundant hetero-interfaces and multiple magnetoelectric loss mechanisms by a facile hydrothermal method.The excess 0.5 oxygen atoms in MnCo_(2)O_(4.5) produce more vacancies and contribute to the enhancement of electrical conductivity.Sequential nanoneedle clusters facilitate multiple reflections and absorption of EMW in the materials,which are accompanied by an abundance of heterogeneous interfaces to improve the dielectric loss.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)composites showed a minimum reflection loss(RLmin)of30.01 dB and a superior effective absorption bandwidth(EAB)of 6.12 GHz(11.88 GHze18 GHz)at a thickness of 2.00 mm.Computer Simulation Technology(CST)revealed that the obtained particles show very low radar crosssection(RCS)values and almost full coverage angles.The maximum reduction of RCS at vertical incidence reaches 19.98 dB m2.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles exhibit outstanding radar attenuation properties,which can effectively inhibit the reflection and scattering of EMW.Therefore,the prepared Co_(2)NiO_(4)@MnCo_(2)O_(4.5)absorbers have great application potential in the field of EMW absorption. | Yi Zhang Shujuan Tan Zhuoting Zhou Xiaomeng Guan Yu Liao Chen Li Guangbin Ji | 2023 | Particuology2023，，10： | 5 |
| 11 | Protective effects of MCI-186 on oxidative damage in a cell model of Alzheimer's disease显示文摘Oxidative stress has an important role in the development of Alzheimer's disease (AD). Beta amyloid protein 25-35 (Aβ25-35) can generate oxygen free radicals, and MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one, edaravone) can specifically eliminate hydroxyl radicals. The present study introduced Aβ25-35 into PC12 cells to establish a cell model of AD, and investigated the neuroprotective effects of MCI-186 on AD. Results showed that MCI-186 had a positive effect on the prevention and treatment of AD by inhibiting protein oxidative products, advanced glycation end products, lipid oxidative end products and DNA oxidative damage in PC12 cells induced by Aβ25-35. | Ming Yu Shujuan Li Wenhui Leng Han Chen Yingquan Wu Lirong Yan | 2010 | Neural Regeneration Research2010，5，16： | 5 |
| 12 | Preparation and properties of PPSU/GO mixed matrix membrane显示文摘Polyphenylene sulfone/graphene oxide(PPSU/GO) mixed matrix membranes with different GO contents are prepared by phase inversion technique using, PEG-1000 as porogen, and N,N-dimethylacetamide(DMAC) as solvent.The hydrophilicity and pure water flux of the membrane are investigated. The morphology, hydrophilicity, thermodynamic stability and compatibility of the membranes are characterized by various techniques such as SEM,TGA, FTIR and so on. The permeation properties of the membrane are measured in terms of pure water flux and bovine serum albumin(BSA) retention. The results indicate that when the GO content is 1.5 wt%, an evenly distributed finger structure has been formed in the mixed matrix membranes. Owing to the presence of GO,the hydrophilicity and the thermal stability of the membranes are improved, and the fouling resistance is also enhanced. | Shujuan Xiao Shouwu Yu Li Yan Ying Liu Xiaoyao Tan | 2017 | Chinese Journal of Chemical Engineering2017，25，4： | 4 |
| 13 | Preparation of monolayer-assembled fluorescent film and its sensing performances to hidden nitroaromatic explosives显示文摘Pyrene was chemically assembled on a glass plate surface in a monolayer manner via spacers con-taining triethylenetetramine (TETA) subunits. It has been demonstrated that the fluorescence emission of the film is sensitive to the presence of trace amount of nitroaromatic compound (NAC) vapors. As discovered in the present work, the response selectivity of the pyrene-functionalized film depends on the length of the spacer, the vapor pressure of a given NAC, and the quencher size. The film shows faster response to those quenchers which have higher vapor pressure and smaller size. Compared to the film with shorter spacers, the present film with longer flexible spacers shows a slower response to the NACs, but higher selectivity to the quencher size. Additionally, the detection limits to common ex-plosives in vapor phase, 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT), are 7.14×10-12 and 5.49×10-11 g·mL-1, respectively. Further examinations indicated that the sensing process is fully re-versible, and the vapors of those common interference such as benzene, toluene, ethanol, and perfume have little effect upon the sensing performances of the film. | LI HuiHui LU FengTing ZHANG ShuJuan HE Gang FANG Yu | 2008 | Chinese Science Bulletin2008，53，11： | 4 |
| 14 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 15 | Alkali-activation reactivity of chemosynthetic Al_2O_3-2SiO_2 powders and their ^(27)Al and ^(29)Si magic-angle spinning nuclear magnetic resonance spectra显示文摘Pure Al_2O_3-2SiO_2 powders were prepared by sol-gel and coprecipitation methods,and their alkaliactivation reactivities were compared.The alkali-activation reactivity of the powder prepared by the sol-gel method was higher than that of the powder prepared by the coprecipitation method.The powders were investigated by ^(27)AI and ^(29)Si magic-angle spinning nuclear magnetic resonance spectroscopy(MAS NMR) to understand the relationship between their structure and alkali-activation reactivity.The ^(27)Al MAS NMR data showed that the five-coordinate AI content of the powder prepared by the sol-gel method was higher than that of the powder prepared by coprecipitation.The higher content of five-coordinate Al corresponded to higher alkali-activation reactivity.The ^(29)Si MAS NMR data showed that for the powder prepared by the sol-gel method,silicon was replaced by aluminum at secondary coordination sites of the central Si atoms during calcination.However,for the powder prepared by single-batch coprecipitation,the main change was from a low degree of polycondensation to a high degree of polycondensation. | Guangjian Zheng Xuemin Cui Dong Huang Jinying Pang Guowei Mo Shujuan Yu Zhangfa Tong | 2015 | Particuology2015，13，5： | 3 |
| 16 | Interfacial engineering of Ni/V2O3 for hydrogen evolution reaction显示文摘Electrocatalytic water splitting offers a sustainable route for hydrogen production,enabling the clean and renewable alternative energy system of hydrogen economy.The scarcity and high-cost of platinum-group-metal(PGM)materials urge the exploration of high-performance non-PGM electrocatalysts.Herein,a unique hierarchical structure of NiA/2O3 with extraordinary electrocatalytic performance(e.g.t overpotentials as low as 22 mV at 20 mA·cm^-2 and 94 mV at 100 mA·cm^-2)toward hydrogen evolution reaction in alkaline electrolyte(1 M KOH)is reported.The investigation on the hierarchical NiA/2O3 with a bimodal size-distribution also offers insight of interfacial engineering that only proper NiA/2O3 interface can effectively improve H20 adsorption,H20 dissociation as well as H adsorption,for an efficient hydrogen production. | Yang Chen Yuan Rao Rongzhi Wang Yanan Yu Qiulin Li Shujuan Bao Maowen Xu Qin Yue Yanning Zhang Yijin Kang | 2020 | Nano Research2020，13，9： | 3 |
| 17 | Photothermally Responsive Conjugated Polymeric Singlet Oxygen Carrier for Phase Change-Controlled and Sustainable Phototherapy for Hypoxic Tumor显示文摘Hypoxia significantly compromises the therapeutic performance of photodynamic therapy(PDT)owing to the oxygen level which plays a key role in the production of singlet oxygen(^(1)O_(2)).Herein,the photothermally responsive phase change materials(PCM)are used to encapsulate 1,4-dimethylnaphthalene-functionalized platinum(II)-acetylide conjugated polymer(CP1)with intense nearinfrared(NIR)absorption to prepare new ^(1)O_(2) nanocarriers(CP1-NCs).The 1,4-dimethylnaphthalene moieties in CP1-NCs can trap the ^(1)O_(2) produced from CP1 under irradiation and form a stable endoperoxide.Then,the endoperoxide undergoes cycloreversion to controllably release ^(1)O_(2) via the NIR light-triggered photothermal effect of CP1 and controllable phase change of PCM,which can be used for oxygen-independent PDT for hypoxic tumor.Furthermore,the in vivo luminescence imagingguided synergistic PDT and photothermal therapy showed better efficiency in tumor ablation.The smart design shows the potent promise of CP1-NCs in PCM-controlled and sustainable phototherapy under tumor hypoxic microenvironment,providing new insights for constructing oxygen-independent precise cancer phototherapeutic platform. | Guo Li Ruyi Zhou Weili Zhao Bo Yu Jie Zhou Shujuan Liu Wei Huang Qiang Zhao | 2020 | Research2020，，1： | 3 |
| 18 | Intake of Vitamin A,Thiamine,Riboflavin,Vitamin C,and Niacin Among Children Aged 6−11 Years Old—China,2016−2017显示文摘Summary What is already known on this topic?Insufficient intake of vitamins is one of the major nutritional problems in children aged 6-11 years old in China,and the problem is particularly severe for rural populations.What is added by this report?Among children aged 6-11 years old in 2016-2017,the average intakes of vitamin A,thiamine. | Wei Piao Lahong Ju Hongyun Fang Qiya Guo Shuya Cai Xiaoli Xu Shujuan Li Xue Cheng Liyun Zhao Dongmei Yu | 2021 | China CDC weekly2021，3，11： | 3 |
| 19 | Cooking Oil and Salt Intakes Among Children Aged 6−17 Years——China,2016−2017显示文摘Summary What is already known on this topic?High-level intakes of both cooking oil and salt are issues of concern in China as they can lead to an increased risk of chronic diseases later in life.Reducing intakes of cooking oil and salt should be prioritized in children.What is added by this report?Among children aged 6-17 years in China in 2016-2017,the median intake of cooking oil and salt were 27.7 and 6.1 g/d,respectively.The percentages of children with intake of cooking oil and salt that exceeded the recommended guidelines were 50.4%and 67.8%,respectively. | Lahong Ju Dongmei Yu Wei Piao Hongyun Fang Qiya Guo Xiaoli Xu Shujuan Li Xue Cheng Shuya Cai Liyun Zhao | 2021 | China CDC weekly2021，3，31： | 3 |
| 20 | Maillard reaction in Chinese household-prepared stewed pork balls with brown sauce:potentially risky and volatile products显示文摘The stewed pork balls with brown sauce(SPB-BS)in China is well known for its delicacy and preferred by consumers.Maillard reaction(MR)is widespread in SPB-BS due to the use of sugar,meat and sauce in the thermal process.However,there is a lack of research on its risk and flavor by MR.By solid phase extraction combined with HPLC-MS,4 kinds of harmful compounds including acrylamide(AA),heterocyclic aromatic amines(HAAs),4-methylimidazole(4-MEI)and furan were analyzed in SPB-BS and their amounts ranged 0.05–0.50 mg/kg.The quantitative formula was proposed to evaluate the risk value of the SPB-BS,after taking into account the content,acceptable daily intake(ADI)and carcinogenicity of each compound.The risk values were in range of 0.57–37.93,suggesting that the risk caused by MR in SPB-BS was low.By head space-solid phase microextraction combined with GC-MS,57 volatile compounds in SPB-BS were identified with the dominant contribution of alcohols,aldehydes,acids and esters.Based on the structures of these compounds and the composition of SPB-BS,lipid oxidation and MR are inferred to be responsible for the formation of the harmful and volatile compounds.In addition,the added sauces and oil provides the main precursors to form the harmful and volatile compounds in SPB-BS,so it is necessary to point out a balance between them in the further study. | He Li Xiangyi Tang Chunjian Wu Shujuan Yu | 2021 | Food Science and Human Wellness2021，10，2： | 2 |
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