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| 1 | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis显示文摘Implant loosening remains a major clinical challenge for osteoporotic patients.This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis,which results in poor bone repair.Strontium(Sr)has been widely accepted as an anti-osteoporosis element.In this study,we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions.The results showed that Ca and Sr exhibited different mineralization behaviors.The main mineralization products for Ca were CaHPO4⋅2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased.The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased.The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion,spreading,proliferation,and osteogenic differentiation.In addition,Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion.Moreover,the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity,improve new bone formation,and enhance bone-implant integration.This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients. | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu | 2021 | Bioactive Materials2021，6，4： | 4 |
| 2 | Microstructure and mechanical propertiesof spray-deposited Al-Si-Fe-Cu-Mg alloy containing Mn显示文摘Al-20Si-5Fe-3Cu-lMg alloy was synthesized by the spray atomization and deposition technique. The microstructure and mechanical properties of the spray deposited hypereutectic Al-Si alloy were studied using optical microscopy, scanning electron microscopy, X-ray diffraction, TEM (Transmission Electron Microscope) and HREM (High-resolution Electron Microscope), DSC (Differential Scanning Calorimetry), microhardness measurement, and tensile tests. The effects of Mn on the microstructural evolution of the highsilicon aluminum alloy after extrusion and heat treatment have been examined. The results show that two kinds of phases, i.e. S (Al2CuMg) and σ(Al5Cu6Mg2), precipitated from matrix and improved the tensile strength of the alloy efficiently at both the ambient and elevated temperatures (300℃). The tensile test results indicate that the spray-deposited Al-20Si-SFe-3Cu-1Mg alloy has better strength than the powder metallurgy processed Al-20Si-3Cu-1Mg alloy at elevated temperature. | Feng Wang, Bin Yang, Hua Cui, Xianjin Duan, and Jishan ZhangState Kev Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，1： | 2 |
| 3 | Impro-ving the bioactivity of NiTi shape memory alloy by heat and alkali treatment显示文摘 | Wei Qiang Cui Zhenduo Yang Xianjin | 2008 | Applied Surface Science2008，255，： | 1 |
| 4 | Structural effects of iron oxide nanoparticles and iron ions on the hydro- thermal carbonization of starch and rice carbohydrates 显示文摘 | CUI Xianjin ANTONIETTI M YU Shuhong | 2006 | Small2006，2，6： | 1 |
| 5 | 显示文摘 | Sang Xiaoming Yang Xianjin Cui Zhenduo | 2004 | Journal of Macromolecular Science2004，43，4： | 1 |
| 6 | StructuraleffectsofironoxidenanoparticlesandironionsonthehyGdrothermalcarbonizationofstarchandricecarbohydrates显示文摘 | Cui Xianjin Antonietti M Yu Shuhong | 2006 | Small2006，2，6： | 1 |
| 7 | Effect of Zr on super-elasticity and mechanical properties of Ti–24<ce:hsp sp='0.25'/>at% Nb–(0, 2, 4)<ce:hsp sp='0.25'/>at% Zr alloy subjected to aging treatment显示文摘 | Qiang Li Mitsuo Niinomi Masaaki Nakai Zhenduo Cui Shengli Zhu Xianjin Yang | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 8 | A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration显示文摘As the population ages,more and more people are suffering from osteoarthritis(OA),resulting in an increasing requirement for joint implants.Surface modification to improve the topology and composition of the implants has been proved to be an effective way to improve the primary stability and long-term success rate of joint implants.In this work,a bionic micro/nano-structure accompanied with a strontium-substituted hydroxyapatite(SrHA)coating was fabricated on titanium(Ti)surface via electrochemical corrosion,ultrasonic treatment,and hydrothermal deposition methods.Thein vitro study demonstrated that the bionic structure and the bioactive apatite could synergistically increase the expressions of integrin-related gene(ITGα5β1)and osteoblastic genes(Col-I and OCN),and thus promote osteoblast growth.In addition,owing to the anti-bone resorption property of Sr^(2+),the coating could effectively inhibit osteoclast differentiation and proliferation.In a word,the prepared samples not only promoted osteogenesis but also inhibited osteoclastogenesis.The in vivo experiment via a rabbit model found that the bionic structured surface provided the pore for new bone ingrowth,which was beneficial to the mechanical interlocking between the implant and bone.Moreover,the bionic structure and bioactive SrHA coating had a synergistic effect on promoting bone formation,osseointegration,and bone-implant bonding strength.This study therefore presented a new strategy to fabricate bio-functionalized Ti-based implants for potential application in orthopedics field. | Zhen Geng Xueping Li Luli Ji Zhaoyang Li Zhenduo Cui Jing Wang Jingyuan Cui Xianjin Yang Changsheng Liu | 2021 | Journal of Materials Science & Technology2021，，20： | 0 |
| 9 | Functional Inorganic Materials with Complex Form: Construction, Self-assembly Principles and Property显示文摘There is a rich and long history of gaining inspiration from the nature for the design of practical materials and systems.Biominerals are well-known composites of inorganic and organic materials in the form of fascinating shapes and highly ordered structures existing in the natural world, such as pearl, oyster shells, corals, ivory, sea urchin spines, cuttlefish bone, limpet teeth, magnetic crystals in bacteria and human bones that are created by living organisms.During the past few decades, it has become one of the most influencing subjects in materials proteins, which involve in all the processes of multicell organisms, such as fertilization, differentiation, development, immunity, infection, and cancer.chemistry to explore new bio-inspired strategies for selfassembling or surface-assembling molecules or colloids to generate materials with controlled morphologies, | YU Shuhong YANG Jian LIU Biao GUO Xiaohui CUI Xianjin | 2011 | Bulletin of the Chinese Academy of Sciences2011，25，2： | 0 |
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