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| 1 | A carbon-oxygen-bridged ladder-type building block for efficient donor and acceptor materials used in organic solar cells显示文摘A carbon-oxygen-bridged ladder-type donor unit(CO5) was invented and prepared via an ‘‘intramolecular demethanolization cyclization' approach. Its single crystal structure indicates enhanced planarity compared with the carbon-bridged analogue indacenodithiophene(IDT). Owing to the stronger electron-donating capability of CO5 than IDT, CO5-based donor and acceptor materials show narrower bandgaps. A donor-acceptor(D-A) copolymer donor(PCO5TPD) and an A-D-A nonfullerene acceptor(CO5IC) demonstrated higher performance than IDT-based counterparts, PIDTTPD and IDTIC, respectively. The better performance of CO5-based materials results from their stronger light-harvesting capability and higher charge-carrier mobilities. | Zuo Xiao Fan Liu Xinjian Geng Jianqi Zhang Shizhe Wang Yujun Xie Zhen Li Huai Yang Yongbo Yuan Liming Ding | 2017 | Science Bulletin2017，62，19： | 16 |
| 2 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 3 | Interpretation Criteria for Standardized Western Blot for the Predominant Species of Borrelia Burgdorferi Sensu Lato in China显示文摘Objective Western blotting (WB;immunoblotting) is a widely used tool for the serodiagnosis of Lyme borreliosis (LB),but so far,no generally accepted criteria for its performance and interpretation have been established in China.The present study was designed to determine the criteria for standardized Western blot for the predominant species of Borrelia burgdorferi sensu lato in China,in which WB was produced with strain PD91 as the representative strain attributed to predominant genospecies Borrelia garinii of Borrelia burgdorferi sensu lato.Methods Approximately 13 bands between 14 and 100 kD were differentiated for strain PD91 by using Gel-Pro analysis software.In a study with 631 serum samples (taken from 127 patients with Lyme borreliosis and 504 controls),all observed bands were documented.To establish criteria for a positive WB result for strain PD91,receiver operating characteristic (ROC) curves were used.Results The following interpretation criteria were recommended:for IgG,at least one band of P83/100,P58,P39,P30,OspC,P17,P66,and OspA;for IgM,at least one band of P83/100,P58,OspA,P30,OspC,P17 or P41.In addition,syphilis,leptospirosis and other related diseases should be excluded when the positive band is P41 in IgM.For IgG criteria,the sensitivity is 73.2%,the specificity is 99.4% and Youden index is 0.726;for IgM criteria,the sensitivity is 50.6%,the specificity is 93.1% and Youden index is 0.437.Conclusion Standardization of WB assays is necessary for comparison of results from different laboratories.Moreover,the criteria of other genospecies of Borrelia burgdorferi sensu lato should be determined in the future to complete the criteria of WB for the diagnosis of the Lyme disease in China. | YI JIANG XUE-XIA HOU ZHEN GENG QIN HAO KANG-LIN WAN | 2010 | Biomedical and Environmental Sciences2010，23，5： | 13 |
| 4 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 5 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 6 | The horizon of bone organoid: A perspective on constructionand application显示文摘Bone defects repair and regeneration by various causes such as tumor resection, trauma, degeneration, etc. havealways been a key issue in the clinics. As one of the few organs that can regenerate after adulthood, bone itselfhas a strong regenerative ability. In recent decades, bone tissue engineering technology provides various types offunctional scaffold materials and seed cells for bone regeneration and repair, which significantly accelerates thespeed and quality of bone regeneration, and many clinical problems are gradually solved. However, the bonemetabolism mechanism is complicated, the research duration is long and difficult, which significantly restrictsthe progress of bone regeneration and repair research. Organoids as a new concept, which is built in vitro withthe help of tissue engineering technology based on biological theory, can simulate the complex biologicalfunctions of organs in vivo. Once proposed, it shows broad application prospects in the research of organdevelopment, drug screening, mechanism study, and so on. As a complex and special organ, bone organoidconstruction itself is quite challenging. This review will introduce the characteristics of bone microenvironment,the concept of organoids, focus on the research progress of bone organoids, and propose the strategies for boneorganoid construction, study direction, and application prospects. | Shuangshuang Chen Xiao Chen Zhen Geng Jiacan Su | 2022 | Bioactive Materials2022，7，12： | 9 |
| 7 | Estimating survival benefit of adjuvant therapy based on a Bayesian network prediction model in curatively resected advanced gallbladder adenocarcinoma显示文摘BACKGROUND The factors affecting the prognosis and role of adjuvant therapy in advanced gallbladder carcinoma(GBC)after curative resection remain unclear.AIM To provide a survival prediction model to patients with GBC as well as to identify the role of adjuvant therapy.METHODS Patients with curatively resected advanced gallbladder adenocarcinoma(T3 and T4)were selected from the Surveillance,Epidemiology,and End Results database between 2004 and 2015.A survival prediction model based on Bayesian network(BN)was constructed using the tree-augmented na?ve Bayes algorithm,and composite importance measures were applied to rank the influence of factors on survival.The dataset was divided into a training dataset to establish the BN model and a testing dataset to test the model randomly at a ratio of 7:3.The confusion matrix and receiver operating characteristic curve were used to evaluate the model accuracy.RESULTS A total of 818 patients met the inclusion criteria.The median survival time was 9.0 mo.The accuracy of BN model was 69.67%,and the area under the curve value for the testing dataset was 77.72%.Adjuvant radiation,adjuvant chemotherapy(CTx),T stage,scope of regional lymph node surgery,and radiation sequence were ranked as the top five prognostic factors.A survival prediction table was established based on T stage,N stage,adjuvant radiotherapy(XRT),and CTx.The distribution of the survival time(>9.0 mo)was affected by different treatments with the order of adjuvant chemoradiotherapy(cXRT)>adjuvant radiation>adjuvant chemotherapy>surgery alone.For patients with node-positive disease,the larger benefit predicted by the model is adjuvant chemoradiotherapy.The survival analysis showed that there was a significant difference among the different adjuvant therapy groups(log rank,surgery alone vs CTx,P<0.001;surgery alone vs XRT,P=0.014;surgery alone vs cXRT,P<0.001).CONCLUSION The BN-based survival prediction model can be used as a decision-making support tool for advanced GBC patients.Adjuvant chemoradiotherapy is expected to improve the survival significantly for patients with node-positive disease. | Zhi-Min Geng Zhi-Qiang Cai Zhen Zhang Zhao-Hui Tang Feng Xue Chen Chen Dong Zhang Qi Li Rui Zhang Wen-Zhi Li Lin Wang Shu-Bin Si | 2019 | World Journal of Gastroenterology2019，25，37： | 9 |
| 8 | Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis显示文摘Background:The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE)due to Clostridium perfringens.In the present study,we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids(BLJ)on growth performance and gut health using a coinfection model of NE in broiler chickens.Methods:Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2×2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged(or not challenged for the control)with Eimeria spp./C.perfringens.Results:Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial(P<0.01),a higher villus height and villus height/crypt depth ratio,and reduced intestinal C.perfringens counts,liver C.perfringens carriage,gut lesion scores and serum fluorescein isothiocyanate dextran(FITC-D)concentrations at 7 d postinfection compared with those of birds without BLJ supplementation(P<0.05).NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels(P<0.05),increased A20 mRNA expression and significantly downregulated TRAF-6,TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation(P<0.05).Compared with the uninfected and untreated birds,the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae levels.Compared with the unsupplemented NE-challenged birds,infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of Erysipelotrichaceae.Conclusion:BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function,positively modulating the gut microbiota community and differentially regulating intestinal immune responses.Our results also suggested that adding BLJ effectively controlled NE infections after experimental Eimeria and Clostridium perfringens coinfection. | Van Hieu Pham Liugang Kan Jinyu Huang Yanqiang Geng Wenrui Zhen Yuming Guo Waseem Abbas Zhong Wang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 8 |
| 9 | A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China显示文摘Objective To study the technique of Western blot for the diagnosis of Lyme disease caused by Borrelia afzelii in China and to establish the standard criteria by operational procedure. Methods FP1, which is the representative strain of B. afzelii in China, was analyzed by SDS‐PAGE, electro transfer and immunoblotting assays. The molecular weights of the protein bands of FP1 were analyzed by Gel‐Pro analysis software. In a study using 451 serum samples (159 patients with Lyme disease and 292 controls), all observed bands were recorded. The accuracy of the WB as a diagnostic test was established by using the ROC curve and Youden index. Results Criteria for a positive diagnosis of Lyme disease were established as at least one band of P83/100, P58, P39, OspB, OspA, P30, P28, OspC, P17, and P14 in the IgG test and at least one band of P83/100, P58, P39, OspA, P30, P28, OspC, P17, and P41 in the IgM test. For IgG criteria, the sensitivity, specificity and Youden index were 69.8%, 98.3%, and 0.681, respectively; for IgM criteria, the sensitivity, specificity and Youden index were 47%, 94.2%, and 0.412, respectively. Conclusion Establishment of WB criteria for B. afzelii is important in validating the diagnostic assays for Lyme disease in China. | LIU Zhi Yun HAO Qin HOU Xue Xia JIANG Yi GENG Zhen WU Yi Mou WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 7 |
| 10 | Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABA_A Receptors in Medial Prefrontal Cortex显示文摘Ethanol is widely known for its ability to cause dramatic changes in emotion, social cognition, and behavior following systemic administration in humans.Human neuroimaging studies suggest that alcohol dependence and chronic pain may share common mechanisms through amygdala-medial prefrontal cortex(m PFC) interactions. However, whether acute administration of ethanol in the m PFC can modulate pain perception is unknown.Here we showed that bilateral microinjections of ethanol into the prelimbic and infralimbic areas of the m PFC lowered the bilateral mechanical pain threshold for 48 h without influencing thermal pain sensitivity in adult rats.However, bilateral microinjections of artificial cerebrospinal fluid into the m PFC or bilateral microinjections of ethanol into the dorsolateral PFC(also termed as motor cortex area 1 in Paxinos and Watson's atlas of The Rat Brain. Elsevier Academic Press, Amsterdam, 2005) failed to do so, suggesting regional selectivity of the effects of ethanol. Moreover, bilateral microinjections of ethanol didnot change the expression of either pro-apoptotic(caspase-3 and Bax) or anti-apoptotic(Bcl-2) proteins, suggesting that the dose was safe and validating the method used in the current study. To determine whether c-aminobutyric acid A(GABA_A) receptors are involved in mediating the ethanol effects, muscimol, a selective GABA_Areceptor agonist, or bicuculline, a selective GABA_A receptor antagonist, was administered alone or co-administered with ethanol through the same route into the bilateral m PFC. The results showed that muscimol mimicked the effects of ethanol while bicuculline completely reversed the effects of ethanol and muscimol. In conclusion, ethanol increases mechanical pain sensitivity through activation of GABA_A receptors in the m PFC of rats. | Kai-Wen Geng Ting He Rui-Rui Wang Chun-Li Li Wen-Jun Luo Fang-Fang Wu Yan Wang Zhen Li Yun-Fei Lu Su-Min Guan Jun Chen | 2016 | Neuroscience Bulletin2016，32，5： | 6 |
| 11 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 12 | Effects of thermal activation conditions on the microstructure regulation of corncob-derived activated carbon for hydrogen storage显示文摘Activated carbons derived from corncob(CACs) were prepared by pyrolysis carbonization and KOH activation. Through modifying activation conditions, samples with large pore volume and ultrahigh BET specific surface area could be obtained. The sample achieved the highest hydrogen uptake capacity of 5.80 wt% at 40 bar and-196?C. The as-obtained samples were characterized by N2-sorption, transmission electron microscopy(TEM) and scanning electron microscopy(SEM). Besides, thermogravimetric analysis was also employed to investigate the activation behavior of CACs. Detailed investigation on the activation parameters reveals that moderate activation temperature and heating rate are favorable for preparing CACs with high surface area, large pore volume and optimal pore size distribution. Meanwhile, the micropore volume between 0.65 nm and 0.85 nm along with BET surface area and total pore volume has great effects on hydrogen uptake capacities. The present results indicate that CACs are the most promising materials for hydrogen storage application. | Dabin Wang Zhen Geng Cunman Zhang Xiangyang Zhou Xupeng Liu | 2014 | Journal of Energy Chemistry2014，23，5： | 6 |
| 13 | New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity显示文摘Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A-R and lavandiolides A,B,C,H,and J.Eight compounds(1,4,10,12,13,and 19-21) were unambiguously confirmed by the single-crystal X-ray diffraction analyses,and the others were elucidated based on IR,UV,HRESIMS,1 D and 2 D NMR experiments,and comparison of the experimental and calculated ECD data.Structurally,all of them were [4+2] Diels-Alder adducts of two monomeric guaianolides.The isolates were evaluated for their cytotoxicity against three human hepatoma cell lines,and 19 compounds demonstrated cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines.Especially,compounds 1,12,14,and 15 exhibited cytotoxicity with IC50 values of 4.4,3.8,7.6,and 6.7 μmol/L(HepG2),9.6,4.6,6.6,and 6.0 μmol/L(SMMC-7721),and 7.6,4.5,6.9,and 5.6 μmol/L(Huh7),respectively.Notably,compound 12 showed the most promising activity against three human hepatoma cell lines and dose-dependently inhibited cell migration and invasion,induced G2/M cell cycle arrest and cell apoptosis in HepG2 cells,down-regulated the expression of BCL-2 and PARP-1,and activated PARP-1 to up-regulate the expression of cleaved-PARP-1. | Lihua Su Xintian Zhang Yunbao Ma Changan Geng Xiaoyan Huang Jing Hu Tianze Li Shuang Tang Cheng Shen Zhen Gao Xuemei Zhang Ji-Jun Chen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 6 |
| 14 | Preparation of CS-CMC Bipolar Membrane and its Application in Electro-generated FeO_4^(2-)显示文摘CS-CMC bipolar membrane was prepared and the cross-section photograph of CS-CMC BM was observed by SEM. FT-IR spectrum indicated that CS-CMC BM contained -N=CRH2+ and -COO- functional groups. The charge density of -N=CRH2+ in CS membrane was about 14.13 mmol/g and the charge density of -COO- in CMC membrane was about 9.01 mmol/g. The electrochemistry properties of CS-CMC BM were also studied. CS-CMC BM not only can effectively stop FeO4 from diffusing into the cathode chamber, but also plays an important role in the supply of OH- consumed during the electro-generated FeO42- process. | Yu Xi REN Zhen CHEN Ri Yao CHEN Xi ZHEN Ya Ming GENG | 2006 | Chinese Chemical Letters2006，17，11： | 5 |
| 15 | Review of geometric error measurement and compensation techniques of ultra-precision machine tools显示文摘Inevitable machine motion errors change the cutting tool trajectory and degrade the machined surface quality.Compared to the mature error measurement technologies developed for traditional precision CNC machine tools,the increasing use of ultra-precision machine tools(UPMTs)has shown some distinctive characteristics in error modelling,measurement,and compensation.This paper attempts to summarise state-of-the-art research in the calibration of geometric errors of UPMTs.A general routine for a UPMT error calibration is proposed in this literature review.Various error modelling methods,instruments,and measurement methods applicable to the geometric error measurement of both the linear and rotary axes are discussed using typical case studies.With respect to these achievements,there is a real concern regarding the reproducibility of measurement sensors used for the calibration of UPMTs and it remains challenging to decompose the volumetric motion error of UPMTs.Owing to the high flexibility in practice,trial cutting and a sensitivity analysis-based error measurement and compensation provide a promising solution to achieve a fast UPMT calibration. | Zongchao Geng Zhen Tong Xiangqian Jiang | 2021 | Light(Advanced Manufacturing)2021，2，2： | 4 |
| 16 | Data Aggregation Scheduling with Guaranteed Lifetime and Efficient Latency in Wireless Sensor Networks显示文摘In scenarios of real-time data collection of long-term deployed Wireless Sensor Networks (WSNs),low-latency data collection with long network lifetime becomes a key issue.In this paper,we present a data aggregation scheduling with guaranteed lifetime and efficient latency in WSNs.We first construct a Guaranteed Lifetime Minimum Radius Data Aggregation Tree (GLMRDAT) which is conducive to reduce scheduling latency while providing a guaranteed network lifetime,and then design a Greedy Scheduling algorithM (GSM) based on finding the maximum independent set in conflict graph to schedule the transmission of nodes in the aggregation tree.Finally,simulations show that our proposed approach not only outperforms the state-of-the-art solutions in terms of schedule latency,but also provides longer and guaranteed network lifetime. | Chen Zhengyu Yang Geng Chen Lei Xu Jian Wang Haiyong Yang Zhen | 2012 | China Communications2012，9，9： | 4 |
| 17 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 18 | Calcium phosphate-based materials regulate osteoclast-mediated osseointegration显示文摘Calcium phosphate-based materials(CaP)have been widely used as bone graft substitutes with a decent osseointegration.However,the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive.The aim of this study is to find the mechanism how osteoclast behaviors mediate bone healing with CaP scaffolds.Recent reports show that behaviors of osteoclast are closely related with osteogenesis,thus we make a hypothesis that active osteoclast behaviors induced by CaP facilitate bone healing.Here,we found a new mechanism that CaP can regulate osteoclast-mediated osseointegration.Calcium phosphate cement(CPC)is selected as a representative CaP.We demonstrate that the osteoclast-mediated osseointegration can be strongly modulated by the stimulation with CaP.An appropriate Ca/P ratio in CaP can effectively promote the RANKL-RANK binding and evoke more activated NF-κB signaling transduction,which results in vigorous osteoclast differentiation.We observe significant improvement of bone healing in vivo,owing to the active coupling effect of osteoclasts.What is more noteworthy is that the phosphate ions released from CaP can be a pivotal role regulating osteoclast activity by changing Ca/P ratio readily in materials.These studies suggest the potential of harnessing osteoclast-mediated osteogenesis in order to develop a materials-manipulated approach for improving osseointegration. | Xiaogang Wang Yuanman Yu Luli Ji Zhen Geng Jing Wang Changsheng Liu | 2021 | Bioactive Materials2021，6，12： | 4 |
| 19 | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis显示文摘Implant loosening remains a major clinical challenge for osteoporotic patients.This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis,which results in poor bone repair.Strontium(Sr)has been widely accepted as an anti-osteoporosis element.In this study,we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions.The results showed that Ca and Sr exhibited different mineralization behaviors.The main mineralization products for Ca were CaHPO4⋅2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased.The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased.The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion,spreading,proliferation,and osteogenic differentiation.In addition,Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion.Moreover,the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity,improve new bone formation,and enhance bone-implant integration.This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients. | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu | 2021 | Bioactive Materials2021，6，4： | 4 |
| 20 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2显示文摘Mutations and transient conformational movements of the receptor binding domain(RBD)that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).To mitigate viral escape,we developed a cocktail of neutralizing antibodies(NAbs)targeting epitopes located on different domains of spike(S)protein.Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs,targeting the N-terminal domain(NTD)and RBD domain of S,effective at n M concentrations.Remarkably,a combination of RBD-targeting NAbs and NTD-binding NAbs,FC05,enhanced the neutralization potency in cell-based assays and an animal model.Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM)structures of antigen-binding fragments bound to S unveil determinants of immunogenicity.Combinations of immunogens,identified in the NTD and RBD of S,when immunized in rabbits and macaques,elicited potent protective immune responses against SARS-CoV-2.More importantly,two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge,without observable antibody-dependent enhancement of infection.These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD. | Li Zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng Jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang Hong-Ying Qiu Lei Wang Zhen Cui Qing Ye Geng Chen Kui-Kui Lu Yin Chen Yu-Tao Chen Hong-Xing Pan Jiaping Yu Wenrong Yao Bao-Li Zhu Jianping Chen Yong Liu Cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu | 2021 | National Science Review2021，8，8： | 4 |
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