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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 3 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 4 | Novel approaches to the treatment of non-small cell lung cancer显示文摘 | Carlos G Ferreira Cynthia Huisman Giuseppe Giaccone | 2002 | Critical Reviews in Oncology and Hematology2002，，1： | 2 |
| 5 | The Methyltetrahydro-β-Carbolines in Maca (Lepidium meyenii)显示文摘 | Gnstavo F G Cynthia G C | 2009 | Evidence-Based Complementary and Alternative Medicine2009，6，3： | 1 |
| 6 | A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabe- tes 显示文摘 | Gustavo FG Cynthia GC Manuel G | 2013 | Toxicol Mechan Methods2013，23，7： | 1 |
| 7 | Preterm premature rupture of membranes: is there an optimal gestatianal age for delivery? 显示文摘 | Joelle M Lieman MD Cynthia G | 2005 | 105(1): 12 -172005，105，1： | 1 |
| 8 | LAS glass-ce- ramic scaffolds by three-dimensional printing 显示文摘 | Andrea Z Cynthia M G Enrico B | 2013 | Jour- nal of the European Ceramic Society2013，33，9： | 1 |
| 9 | A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans显示文摘 | Daniel D G Cynthia M G | 2002 | J Am Coll Nutr2002，21，5： | 1 |
| 10 | Using diatoms to assess the biological condition of large rivers in Idaho (USA)显示文摘 | Leska S F Cynthia G | 2002 | Freshwater Biology2002，47，： | 1 |
| 11 | A quantification of short-term macroaggregate dynamics: influences of wheat residue input and texture显示文摘 | STEVEN D G JOHAN S CYNTHIA B | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 12 | Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E 2 and selective prostaglandin receptor agonists in murine osteoblastic cells显示文摘 | Yoko Sakuma Ziaodong Li Carol C Pilbeam Cynthia B Alander Daichi Chikazu Hiroshi Kawaguchi Lawrence G Raisz | 2003 | Bone2003，，5： | 1 |
| 13 | Relationship between social support and positive health practices in middle adolescents显示文摘 | CYNTHIA G A | 2008 | J Pediatr Health Care2008，22，2： | 1 |
| 14 | Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Kim A Eagle Shaun G Goodman álvaro Avezum Andrzej Budaj Cynthia M Sullivan José López-Sendón | 2002 | The Lancet . 2002 (9304)2002，，9304： | 1 |
| 15 | Study of vertical transmission of fowl adenoviruses显示文摘 | HELENA G CYNTHIA P DAVPR O | 2006 | Can J Vet Res2006，70，： | 1 |
| 16 | Serologic monitoring of a broiler breeder flock previously affected by inclusion body hepatitis and testing of the progeny for vertical transmission of fowl adenoviruses显示文摘 | CYNTHIA P HELENA G DAVOR O | 2007 | Can J Vet Res2007，71，： | 1 |
| 17 | The Methyltetrahydro-fl-Carbolines in Maca (Lepidium meyenil)显示文摘 | Gustavo F G Cynthia G C | 2009 | Evidence-Based Complementary and Alternative Medicine2009，6，3： | 1 |
| 18 | Reputation in an Internet Auction Market显示文摘 | McDonald Cynthia G V.Carlos Slawson Jr | | 0，，04： | 1 |
| 19 | Escalating world- wide use of urea a global change contributing to coastal eutroph- ication 显示文摘 | PATRICIA M G JOHN H CYNTHIA H | 2006 | Biogeochemistry2006，77，3： | 1 |
| 20 | The Effects of Intensive Glycemic Control on Neuropathy in the VA Cooperative Study on Type II Diabetes Mellitus (VA CSDM)显示文摘 | Nasrin Azad Nicholas V Emanuele Carlos Abraira William G Henderson John Colwell Seymore R Levin Frank Q Nuttall John P Comstock Clark T Sawin Cynthia Silbert Frank A Rubino | 2000 | Journal of Diabetes and Its Complications2000，，5： | 1 |
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