|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 2 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 3 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 4 | 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)显示文摘 | Hani Jneid Jeffrey L. Anderson R. Scott Wright Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2012 | Journal of the American College of Cardiology2012，，7： | 1 |
| 5 | Characterization Tests for Mineral Fillers Related to Performance of Asphalt Paving Mixtures显示文摘 | Prithvi S K Cynthia Y L Frazier P J | 1998 | NAPA Report1998，，2： | 1 |
| 6 | 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | R. Scott Wright Jeffrey L. Anderson Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats Hani Jneid A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2011 | Journal of the American College of Cardiology2011，，19： | 1 |
| 7 | Assessing the performance of biological filtration as pretreatment to low pressure membranes for drinking water显示文摘 | Cynthia H Huck P M Peldszus S | 2009 | Environ Sci Technol2009，43，10： | 1 |
| 8 | Composite variable formulations for express shipment service network design 显示文摘 | Armacost Andrew P Barnhart Cynthia Ware Keith A | 2002 | Transportation Science2002，36，： | 1 |
| 9 | Epidemiology and natural history of common bile duct stones and prediction of disease显示文摘 | Lee MS Sum P | 2002 | Gastrointest Endosc2002，56，： | 1 |
| 10 | Resources, knowl- edge and influence: the organizational effects of inter - organizational collaboration 显示文摘 | Cynthia H Nelson P Thomas B L | 2003 | Journal of Management Studies2003，40，2： | 1 |
| 11 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 12 | Anaerobic biotransformation of estrogens显示文摘 | CYNTHIA P C KATHLEEN L L | 2006 | Sci Total Environ2006，367，23： | 1 |
| 13 | Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection显示文摘 | Robinson P Okhuysen PC Cynthia L | 2001 | Cytokine2001，15，1： | 1 |
| 14 | Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica显示文摘 | Nidia L S Magda R L Cynthia O P | 2006 | Biochem Cell2006，84，： | 1 |
| 15 | Mechanisms of drug-induced liver injury显示文摘 | Michael P Cynthia Ju | 2006 | AAPS J2006，8，1： | 1 |
| 16 | Regulatory Role of Host CD8^+ T Lymphocytes in Experimental Graft-versus-Host Disease across a Single Major Histocompatibility Complex Class II Incompatibility 显示文摘 | Aurore DL Cynthia P Frederic P | 2005 | Transplantation2005，80，9： | 1 |
| 17 | Study of vertical transmission of fowl adenoviruses显示文摘 | HELENA G CYNTHIA P DAVPR O | 2006 | Can J Vet Res2006，70，： | 1 |
| 18 | Serologic monitoring of a broiler breeder flock previously affected by inclusion body hepatitis and testing of the progeny for vertical transmission of fowl adenoviruses显示文摘 | CYNTHIA P HELENA G DAVOR O | 2007 | Can J Vet Res2007，71，： | 1 |
| 19 | Nursing students ’ knowledge and attitudesregarding pain显示文摘 | Louise P Cynthia L | 2006 | Pain Management Nursing2006，17，4： | 1 |
| 20 | 2012 ACCF/ AHA/HRS focused update of the 2008 guidelines for device-based therapy of dardiac rhythm abnormalities : A report of the american college of cardiology founda- tion/american heart association task force on practice guidelines显示文摘 | Cynthia M Tracy E John P | 2012 | Circulation2012，126，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员