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| 1 | Pharmacokinetics and enterohepatic circulation of jervine,an antitumor steroidal alkaloid from Veratrum nigrum in rats显示文摘Jervine,a novel steroidal alkaloid from Veratrum nigrum L.,exhibits both antitumor effect and potential toxicity.The aim of study was to characterize the pharmacokinetic behaviors and enterohepatic circulation of jervine in rats.A rapid and simple ultra-high performance liquid chromatography-tandem mass spectrometric method was developed and validated for quantification of jervine and alpinetin (internal standard) in rat plasma.After extraction from rat plasma by a simple protein-precipitation method,the analyte was separated on a C18 column (2.1 mm×50 mm,1.7μm) using water with 0.1%formic acid and acetonitrile as the mobile phase delivered at a flow rate of 0.4mL/min.Jervine and alpinetin were determined in the positive mode with multiple reaction monitoring (MRM) of the ion transitions at m/z426.3→108.8 and m/z 271.0 166.9,respectively.Molecular docking method was used to investigate the binding of jervine to p-glycoprotein and dehydroepiandrosterone sulfotransferase.The method was well validated within acceptance limits including specificity,matrix effect,recovery,precision,accuracy,and stability,and was successfully applied to the pharmacokinetic study of jervine after oral and intravenous administration to rats.Jervine presented a small volume of distribution,fast absorption,high oral bioavailability,and enterohepatic circulation.The enterohepatic circulation was first observed in veratrum alkaloids,and was further investigated by molecular docking studies,which was related to the binding of jervine to p-glycoprotein and dehydroepiandrosterone sulfotransferase.The pharmacokinetic properties and enterohepatic circulation of jervine in rats provided a significant basis for the drug-drug interaction and toxicity study in the future. | Bingjing Zheng Caihong Wang Wenwen Song Xiaoxia Ye Zheng Xiang | 2019 | Journal of Pharmaceutical Analysis2019，9，5： | 4 |
| 2 | Antimicrobial ability of Cu^2+-montmorillonite显示文摘 | Yuhang Zhou Meisheng Xia Ying Ye Caihong Hu | 2004 | Applied Clay Science2004，27，： | 1 |
| 3 | “Nanocompoundsite”:Nano phased polymer dispersed in inorganic matrix via covalent bonds显示文摘Herein we demonstrate a new strategy to construct inorganic–organic“nanocompoundsite”,i.e.,a material that nano phased polymer is dispersed in consecutive inorganic matrix via covalent bonds,which is different from the conventional nanocomposite with polymer as matrix and inorganic nanomaterials as dispersed phase.As a representative system,SiOx/polydimethylsiloxane(PDMS)nanocompoundsite was prepared from a polymeric precursor of perhydropolysilazane(PHPS)modified by carbohydroxyl end-capped PDMS(HOC-PDMS),through a room-temperature vacuum ultraviolet(VUV)irradiation manner.By adjusting HOC-PDMS/PHPS ratio below 20%,PDMS fully binds to the PHPS derived SiOx matrix via Si-O-C bond to form the inorganic-organic SiOx/PDMS nanocompoundsite(ISPN)without noticeable phase separation.The introduction of PDMS into ISPN renders its initial decomposition temperature increase over 110℃.The remarkable enhancement of thermal stability for PDMS is due to the restriction of terminal hydroxyl induced back-biting reaction and main chain degradation by the inorganic matrix and the covalent binding between PDMS and SiOx.This novel strategy can further extend to hydroxyl terminated PDMS,polyethylene glycol,and acrylic resin,with the initial decomposition temperature of each polymer increasing by over 110,150 and 100℃,respectively.More importantly,the nanocompoundsite combines the characteristics of inorganic matrix and polymer.The coating based on SiOx/PDMS nanocompoundsite exhibits good flexibility,outstanding interfacial binding strength,ultra-high hardness as well as excellent hydrophobicity. | Xiang Guo Pengfei Li Guoming Liu Ye Tian Zongbo Zhang Caihong Xu Lei Jiang | 2022 | Nano Research2022，15，7： | 0 |
| 4 | Alantolactone inhibits proliferation,metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways显示文摘Although there are many therapeutic strategies such as surgery and chemotherapy,the prognosis of osteosarcoma(OS)is still far from being satisfactory.It is urgent to develop more effective,tolerable and safe drugs for the treatment of OS.In the present study,we investigated the anti-OS activity of Alantolactone(ALT),a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium,and probed the possible mechanism involved.We demonstrated that ALT significantly inhibited cell proliferation of various human OS cell lines while had relative lower cytotoxicity against normal cells.Then,we validated that ALT reduced migration,decreased invasion possibly through reversing epithelial mesenchymal transition(EMT)process and suppressing Matrix metalloproteinases(MMPs).Moreover,we confirmed that ALT promoted apoptosis and arrested cell cycle at G2/M phase of human OS cells in vitro.In addition,we confirmed that ALT restrained tumor growth and metastasis of OS 143 cells in a xenograft model in vivo.Mechanistically,ALT inhibited the activity of Wnt/β-catenin and p38,ERK1/2 and JNK Mitogen Activated Protein Kinases(MAPKs)signal pathway.Notably,the combination of ALT and Wnt/β-catenin inhibitor,as well as the combination of ALT and MAPKs inhibitors resulted in a synergistically effect on inhibiting the proliferation,migration and invasion of OS cells.Collectively,our results validate the ALT may inhibit proliferation,metastasis and promotes apoptosis of human OS cells possibly through suppressing Wnt/β-Catenin and MAPKs signaling pathways. | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2022 | Genes & Diseases2022，9，2： | 0 |
| 5 | Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]显示文摘 | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 6 | Diverse bacterial populations of PM_(2.5) in urban and suburb Shanghai,China显示文摘Airborne bacteria play key roles in terrestrial and marine ecosystems and human health,yet our understanding of bacterial communities and their response to the environmental variables lags significantly behind that of other components of PM_(2.5).Here,atmospheric fine particles obtained from urban and suburb Shanghai were analyzed by using the qPCR and Illumina Miseq sequencing.The bacteria with an average concentration of 2.12× 10^(3 )cells/m^(3),were dominated by Sphingomonas,Curvibacter,Acinetobacter,Bradyrhizobium,Methylobacterium,Halomonas,Aliihoeflea,and Phyllobacterium,which were related to the nitrogen,carbon,sulfur cycling and human health risk.Our results provide a global survey of bacterial community across urban,suburb,and high-altitude sites.In Shanghai(China),urban PM2.5 harbour more diverse and dynamic bacterial populations than that in the suburb.The structural equation model explained about 27%,41%,and 20%^78%of the variance found in bacteria diversity,concentration,and discrepant genera among urban and suburb sites.This work furthered the knowledge of diverse bacteria in a coastal Megacity in the Yangtze river delta and emphasized the potential impact of environmental variables on bacterial community structure. | Caihong Xu Jianmin Chen Zhikai Wang Hui Chen Hao Feng Lujun Wang Yuning Xie Zhenzhen Wang Xingnan Ye Haidong Kan Zhuohui Zhao Abdelwahid Mellouki | 2021 | Frontiers of Environmental Science & Engineering2021，15，3： | 0 |
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