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| 1 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 2 | Dynamic performance and energy efficiency of reflective and insulative composite coating on building exterior wall显示文摘Reflective and insulative composite coatings are a new energy-saving material with high solar reflectance and extremely low thermal conductivity for buildings.The optimization and impact of high solar reflectance and low thermal conductivity on the insulating capacity of walls remain uncertain.This work investigates the dynamic thermal performance and energy efficiency of a reflective and insulative composite coating in regions with hot summer and warm winter.A simplified thermal resistance-heat capacitance model of an exterior building wall is established to predict thermal performance.The dynamic temperature and heat flow of the wall are predicted to reduce heat loss through the interior surface of the wall and compared to the conventional coating.The specific impact of the thermal conductivity and solar reflectance of the coating on the heat loss is further investigated to minimize heat loss of the wall.This research shows that the composite coating shows better performance on adjusting outdoor climate change than the other coating.Compared with cement,it reduces the maximum temperature of the exterior surface of the wall by 7.45°C,and the heat loss through the interior surface of the wall by 38%.The heat loss is reduced with the increase of solar reflectance and the reduction of thermal conductivity.The results can provide a useful reference and guidance for the application of reflective and insulative composite coating on building exterior wall to promote their energy-saving use on building envelopes. | Guangpeng Zhang Huijun Wu Jia Liu Jianming Yang Huakun Huang Yujie Ding Lei Xie | 2023 | Building Simulation2023，16，12： | 1 |
| 3 | A near-complete genome assembly of the allotetrapolyploid Cenchrus fungigraminus(JUJUNCAO)provides insights into its evolution and C4 photosynthesis显示文摘JUJUNCAO(Cenchrus fungigraminus;2n=4x=28)is a Cenchrus grass with the highest biomass production among cultivated plants,and it can be used for mushroom cultivation,animal feed,and biofuel production.Here,we report a nearly complete genome assembly of JUJUNCAO and reveal that JUJUNCAO is an allopolyploid that originated2.7 million years ago(mya).Its genome consists of two subgenomes,and subgenome A shares high collinear synteny with pearl millet.We also investigated the genome evolution of JUJUNCAO and suggest that the ancestral karyotype of Cenchrus split into the A and B ancestral karyotypes of JUJUNCAO.Comparative transcriptome and DNA methylome analyses revealed functional divergence of homeologous gene pairs between the two subgenomes,which was a further indication of asymmetric DNA methylation.The three types of centromeric repeat in the JUJUNCAO genome(CEN137,CEN148,and CEN156)may have evolved independently within each subgenome,with some introgressions of CEN156 from the B to the A subgenome.We investigated the photosynthetic characteristics of JUJUNCAO,revealing its typical C4 Kranz anatomy and high photosynthetic efficiency.NADP-ME and PEPCK appear to cooperate in the major C4 decarboxylation reaction of JUJUNCAO,which is different from other C4 photosynthetic subtypes and may contribute to its high photosynthetic efficiency and biomass yield.Taken together,our results provide insights into the highly efficient photosynthetic mechanism of JUJUNCAO and provide a valuable reference genome for future genetic and evolutionary studies,as well as genetic improvement of Cenchrus grasses. | Huakun Zheng Baiyu Wang Xiuting Hua Ruiting Gao Yuhao Wang Zixin Zhang Yixing Zhang Jing Mei Yongji Huang Yumin Huang Hui Lin Xingtan Zhang Dongmei Lin Siren Lan Zhongjian Liu Guodong Lu Zonghua Wang Ray Ming Jisen Zhang Zhanxi Lin | 2023 | Plant Communications2023，4，5： | 1 |
| 4 | Smart contract token-based privacy-preserving access control system for industrial Internet of Things显示文摘Due to mobile Internet technology's rapid popularization,the Industrial Internet of Things(IIoT)can be seen everywhere in our daily lives.While IIoT brings us much convenience,a series of security and scalability issues related to permission operations rise to the surface during device communications.Hence,at present,a reliable and dynamic access control management system for IIoT is in urgent need.Up till now,numerous access control architectures have been proposed for IIoT.However,owing to centralized models and heterogeneous devices,security and scalability requirements still cannot be met.In this paper,we offer a smart contract token-based solution for decentralized access control in IIoT systems.Specifically,there are three smart contracts in our system,including the Token Issue Contract(TIC),User Register Contract(URC),and Manage Contract(MC).These three contracts collaboratively supervise and manage various events in IIoT environments.We also utilize the lightweight and post-quantum encryption algorithm-Nth-degree Truncated Polynomial Ring Units(NTRU)to preserve user privacy during the registration process.Subsequently,to evaluate our proposed architecture's performance,we build a prototype platform that connects to the local blockchain.Finally,experiment results show that our scheme has achieved secure and dynamic access control for the IIoT system compared with related research. | Weizheng Wang Huakun Huang Zhimeng Yin Thippa Reddy Gadekallu Mamoun Alazab Chunhua Su | 2023 | Digital Communications and Networks2023，9，2： | 0 |
| 5 | Alantolactone inhibits proliferation,metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways显示文摘Although there are many therapeutic strategies such as surgery and chemotherapy,the prognosis of osteosarcoma(OS)is still far from being satisfactory.It is urgent to develop more effective,tolerable and safe drugs for the treatment of OS.In the present study,we investigated the anti-OS activity of Alantolactone(ALT),a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium,and probed the possible mechanism involved.We demonstrated that ALT significantly inhibited cell proliferation of various human OS cell lines while had relative lower cytotoxicity against normal cells.Then,we validated that ALT reduced migration,decreased invasion possibly through reversing epithelial mesenchymal transition(EMT)process and suppressing Matrix metalloproteinases(MMPs).Moreover,we confirmed that ALT promoted apoptosis and arrested cell cycle at G2/M phase of human OS cells in vitro.In addition,we confirmed that ALT restrained tumor growth and metastasis of OS 143 cells in a xenograft model in vivo.Mechanistically,ALT inhibited the activity of Wnt/β-catenin and p38,ERK1/2 and JNK Mitogen Activated Protein Kinases(MAPKs)signal pathway.Notably,the combination of ALT and Wnt/β-catenin inhibitor,as well as the combination of ALT and MAPKs inhibitors resulted in a synergistically effect on inhibiting the proliferation,migration and invasion of OS cells.Collectively,our results validate the ALT may inhibit proliferation,metastasis and promotes apoptosis of human OS cells possibly through suppressing Wnt/β-Catenin and MAPKs signaling pathways. | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2022 | Genes & Diseases2022，9，2： | 0 |
| 6 | Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]显示文摘 | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 7 | How precipitation and grazing influence the ecological functions of drought-prone grasslands on the northern slopes of the Tianshan Mountains, China?显示文摘Drought-prone grasslands provide a critical resource for the millions of people who are dependent on livestock for food security.However,this ecosystem is potentially vulnerable to climate change(e.g.,precipitation)and human activity(e.g.,grazing).Despite this,the influences of precipitation and grazing on ecological functions of drought-prone grasslands in the Tianshan Mountains remain relatively unexplored.Therefore,we conducted a systematic field investigation and a clipping experiment(simulating different intensities of grazing)in a drought-prone grassland on the northern slopes of the Tianshan Mountains in China to examine the influences of precipitation and grazing on aboveground biomass(AGB),soil volumetric water content(SVWC),and precipitation use efficiency(PUE)during the period of 2014–2017.We obtained the meteorological and SVWC data using an HL20 Bowen ratio system and a PR2 soil profile hydrometer,respectively.We found that AGB was clearly affected by both the amount and seasonal pattern of precipitation,and that PUE may be relatively low in years with either low or excessive precipitation.The PUE values were generally higher in the rapid growing season(April–July)than in the entire growing season(April–October).Overall,moderate grazing can promote plant growth under water stress conditions.The SVWC value was higher in the clipped plots than in the unclipped plots in the rapid growing season(April–July),but it was lower in the clipped plots than in the unclipped plots in the slow growing season(August–October).Our findings can enhance the understanding of the ecological effects of precipitation and grazing in drought-prone grasslands and provide data that will support the effective local grassland management. | HUANG Xiaotao LUO Geping CHEN Chunbo PENG Jian ZHANG Chujie ZHOU Huakun YAO Buqing MA Zhen XI Xiaoyan | 2021 | Journal of Arid Land2021，13，1： | 0 |
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