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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 2 |
| 3 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 4 | Analysis of the strain transfer in a new FBG sensor for structural health monitoring显示文摘 | Torres B Payá-Zaforteza I Calderón P A | 2011 | Engineering Structures2011，33，2： | 1 |
| 5 | On a problem of Mihlim显示文摘 | CALDER(O)N A P ZYGMUND A | 1995 | Trans Amer Math Soc1995，78，2： | 1 |
| 6 | On singular integral with variable kernels显示文摘 | CALDER(O)N A P ZYGMUND A | 1978 | Appl Analysis1978，7，2： | 1 |
| 7 | High frequency precursor analysisprior to a rockburst显示文摘 | Calder P N Madsen D | 1990 | Rockburst an Seimicity in Mines1990，，1： | 1 |
| 8 | Parabolic maximal functions associated with a distribution显示文摘 | CALDER(o)N A P TORKINSKY A | | 0，，： | 1 |
| 9 | Parabolic maximal functions associated with a distribution Ⅱ显示文摘 | CALDER(O)N A P TORKINSKY A | | 0，，： | 1 |
| 10 | Analysis of high frequency micro seismicity recorded at an underground hard rock mine显示文摘 | BUTT S D APEL D B CALDER P N | 1997 | Pure and Applied Geophysics1997，150，34： | 1 |
| 11 | Thermoluminescence analysis for testing the irradiation of spices显示文摘 | BBeneitez P Correcher V Millán A Calderón T | 1994 | Journal of Radioanalytical and Nuclear Chemistry1994，185，： | 1 |
| 12 | New data on thermoluminescence of inorganic dust from herbs and spices显示文摘 | Calderón T Correcher V Millán A Beneitez P Rendell H M Larsson M | 1995 | Journal of Physics D-applied Physics1995，28，： | 1 |
| 13 | Chemicaldifferences in soil organic matter fractions determined by diffuse-reflectance mid-infrared spectroscopy显示文摘 | Calderón F J Reeves J B Collins H P | | 0，，02： | 1 |
| 14 | On Singular Integrals with Variable Kernels显示文摘 | Calder ó n A P Zygmund A | 1978 | Appl Anal1978，7，： | 1 |
| 15 | The use of high frequency and mine-wide microseismic systems to monitor the movement of blasting induced stresses 显示文摘 | Butt S D Calder P N Apel D B | 2000 | CIM Bulletin2000，93，1040： | 1 |
| 16 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 1 |
| 17 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 18 | Variations incarotenoids,vitamins A and E,and color in cow's plasma andmilk following a shift from hay diet to diets containing increasinglevels of carotenoids and vitamin E显示文摘 | Calderón F Chauveau-Duriot B Pradel P | 2007 | J Dairy Sci2007，90，12： | 1 |
| 19 | Antioxidant activity and rosmarinic acid changes in salicylic acid-treated Thymus membranaceus shoots显示文摘 | Víctor Pérez-Tortosa Antonio López-Orenes Ascensión Martínez-Pérez María A. Ferrer Antonio A. Calderón | 2011 | Food Chemistry2011，，2： | 1 |
| 20 | The fusion protein signal-peptide-coding region of canine distemper virus:A useful tool for phylogenetic reconstruction and lineage identification显示文摘 | Sarute N Calderón M G Pérez R | 2013 | PLoS One2013，8，63： | 1 |
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