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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Transmission electron microscopy of Listeria innocua treated by pulsed electric fields and nisin in skimmed milk显示文摘 | Calderó n-Miranda M L Barbosa-Cá novas G V Swanson B G | 1999 | International Journal of Food Microbiology1999，51，： | 1 |
| 3 | Indentification and characterization of cells infiltrating the graft and aqueous humour in rat allograft rejection显示文摘 | LARKIN D F CALDER V L LIGHTMAN S L | 1997 | Clin Exp Immunol1997，107，2： | 1 |
| 4 | Transmission electron microscopy of listeria innacua treated by PEF and nisin in skimmed milk显示文摘 | Calderón-Miranda M L Barbosa-C novas G V Swanson B G | 1999 | International Journal of Food Microbiology1999，51，1： | 1 |
| 5 | Antioxidant activity and rosmarinic acid changes in salicylic acid-treated Thymus membranaceus shoots显示文摘 | Víctor Pérez-Tortosa Antonio López-Orenes Ascensión Martínez-Pérez María A. Ferrer Antonio A. Calderón | 2011 | Food Chemistry2011，，2： | 1 |
| 6 | Lymphocyte adhesion and transendothelial migration in the central nervous system:the role of LFA-1,ICAM-1,VLA-4 and VCAM-1显示文摘 | Wang Y Calder V L | 1995 | Immunology1995，86，3： | 1 |
| 7 | Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future direetions显示文摘 | Calder P C Jensen G L Koletzko B V | 2010 | Intensive Care Med2010，36，5： | 1 |
| 8 | Identification and characterization of cells infiltrating the graft and aqueous hu- mour in rat corneal allograft rejection 显示文摘 | Larkin D F Calder V L Lightman S L | 1997 | Clin Exp Immu- nol1997，107，2： | 1 |
| 9 | Clinical and immunological features of atopic keratoconjunctivitis显示文摘 | Zhan H Smith L Calder V | | 0，，： | 1 |
| 10 | Histopathologic findings in chickens experimentally infected with Gallibacterium anatis by nasal instillation显示文摘 | Zepeda V A Calderón-Apodaca N L Paasch M L | 2010 | Avian Dis2010，54，4： | 1 |
| 11 | Inactivation of Listeria innacua in skim milk by pulsed electric fields and nisin显示文摘 | María L Calderón-Miranda Gustavo V Barbosa-Cnovas Barry G Swanson | 1999 | International Journal of Food Microbiology1999，51，1： | 1 |
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