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| 1 | Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration显示文摘在到女繁殖的道的从男性的旅行,哺乳动物的精子经验自然渗透的减少(例如在老鼠,从 ~ 在到 ~ 的尾 epididymis 的 415 mOsm 在子宫的洞的 310 mOsm ) 。精子演变为活动性激活利用这张力减退的暴露,同时高效地沉默张力减退的房间胀大的否定影响。以前的生理并且药理学研究显示出那个离子控制隧道的水流入 / 流出活跃地涉及精子的过程体积规定;然而,没有特定的精子蛋白质为这快速的 osmoadaptation 被发现负责。这里,我们报导 aquaporin3 (AQP3 ) 是在老鼠和人的一条精子水隧道。Aqp3 缺乏的精子响应张力减退显示出正常活动性激活,但是显示增加的危险到张力减退的房间胀大,在进入以后,由增加的尾巴弯曲描绘了子宫。精子缺点是在男性女性的繁殖的道转变期间响应生理的张力减退的应力胀大的损害精子体积规定和进步房间的结果。微速摄影的成像表明房间体积扩大在细胞质的微滴开始,强迫尾巴到有角并且由于机械膜段形成像发卡的结构。尾巴变丑妨碍了精子移植进输卵管,导致损害授精并且减少了男富饶。这些数据为精子作为一条必要的膜小径建议 AQP3 平衡 “ 的规章的卷减少(RVD ) ; trade-off”在在生理的张力减退之上胀大的精子活动性和房间之间,从而优化 postcopulatory 精子行为。 | Qi Chen Hongying Peng Li Lei Ying Zhang Haibin Kuang Yujing Cao Qi-xian Shi Tonghui Ma Enkui Duan | 2011 | Cell Research2011，21，6： | 13 |
| 2 | The mechanisms of traditional Chinese medicine underlying the prevention and treatment of atherosclerosis显示文摘Atherosclerosis(AS) is a chronic inflammatory disease associated with high morbidity and mortality. The incidence of AS is increasing in the last decades. So development of safe and effective therapeutics for treating AS has become prominently important. Although there are numerous chemical drugs available for treating AS, some drugs are not effective and some have serious side effects. Traditional Chinese medicine(TCM) has a long history for the prevention and treatment of AS due to its less side effects and superior efficacy. This paper describes the effectiveness and underlying mechanisms for prevention and treatment of AS by TCM or its active components. Some TCM, e.g. XuemaiNing, Tongxinluo and Salvia miltiorrhiza have been reported to have cardio-protective effect. Some active components of TCM, e.g. saikosaponin-A, kuwanon G, luteolin and β-elemene have been isolated from various TCM and demonstrated to have beneficial effects on prevention and treatment of AS. | LI Ting-Ting WANG Zhi-Bin LI Yang CAO Feng YANG Bing-You KUANG Hai-Xue | 2019 | Chinese Journal of Natural Medicines2019，17，6： | 12 |
| 3 | Commissioning of laser electron gamma beamline SLEGS at SSRF显示文摘The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and technology.It was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation Facility.The slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray beams.The SLEGS officially completed its commissioning from July to December 2021.Gamma rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the test.This paper reports the results from commissioning the SLEGS beamline. | Hong-Wei Wang Gong-Tao Fan Long-Xiang Liu Hang-Hua Xu Wen-Qing Shen Yu-Gang Ma Hiroaki Utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui Hao Kai-Jie Chen Sheng Jin Yu-Xuan Yang Xin-Rong Hu Xin-Xiang Li Pan Kuang | 2022 | Nuclear Science and Techniques2022，33，7： | 8 |
| 4 | Effects of Formulated Fertilizer Synergist on Abscisic Acid Accumulation, Proline Content and Photosynthetic Characteristics of Rice under Drought显示文摘To investigate the effects of formulated fertilizer synergist on the drought tolerance in rice,pot experiment was conducted to analyze the photosynthetic characteristics and the accumulation of abscisic acid(ABA)and proline in middle-season rice variety Peiliangyou 93.The synergist could improve the net photosynthetic rate,and coordination between the water loss and the CO2 absorption as well as reduce the harmful effect on photosynthetic process under drought conditions.Under drought,the ABA accumulated massively both in roots and leaves,while the ABA content in roots was far higher than that in leaves.The results indicate that synergist could increase the ABA accumulation,but reduce the proline accumulation in rice plant under drought. | WANG Shao-xian XIA Shi-tou PENG Ke-qin KUANG Feng-chun CAO Yong XIAO Lang-tao | 2007 | Rice science2007，14，1： | 7 |
| 5 | Numerical studies of gas hydrate evolution time in Shenhu area in the northern South China Sea显示文摘Although the Shenhu sea area has been a topic and focus of intense research for the exploration and study of marine gas hydrate in China, the mechanism of gas hydrate accumulation in this region remains controversial. The formation rate and evolution time of gas hydrate are the critical basis for studying the gas hydrate formation of the Shenhu sea area. In this paper, based on the positive anomaly characteristics of chloride concentration that measured in the GMGS3-W19 drilling site is higher than the seawater value, we numerically simulated the gas hydrate formation time of GMGS3-W19 site. The simulation results show that the gas hydrate formation rate positively correlates with the chloride concentration when the hydrate reaches the measured saturation. The formation time of gas hydrate in the GMGS3-W19 site is approximately 30 ka. Moreover, the measured chloride concentration is consistent with the in-situ chloride concentration, indicating that the formation rate of gas hydrate at the GMGS3-W19 site is very fast with a relatively short evolution time. | Yun-xin Fang Jing-an Lu Jin-qiang Liang Zeng-gui Kuang Yun-cheng Cao Duo-fu Chen | 2019 | China Geology2019，2，1： | 6 |
| 6 | Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress显示文摘目的: Sulforaphane (SFN ) ,自然饮食的 isothiocyanate,被发现为心血管的疾病施加有益的效果。这研究试图调查在心肌的 hypoxia/reoxygenation (H/R ) 的一个模型位于 SFN 的保护的效果下面的机制在 vitro.Methods 的损害: 有 SFN 的有教养的新生的老鼠 cardiomyocytes pretreated 受到组织缺氧由 3-h 氧化跟随了的 3-h。房间生存能力和 apoptosis 被检测。Caspase-3 活动和 mitochondrial 膜潜力(Δ Ψ m ) 被测量。表示嗯压力相关的 apoptotic 蛋白质与西方的污点分析被分析。沉默信息管理者 1 (SIRT1 ) 活动与 SIRT1 deacetylase fluorometric 试金 kit.Results 被决定: SFN (0.1-5 μ mol/L ) dose-dependently 改进了 cardiomyocytes,减少的 apoptotic 房间和压制的 caspase-3 的生存能力活动。同时, SFN 显著地减轻了 Δ 的损坏; Ψ m 并且减少表示嗯压力相关的 apoptosis 蛋白质(GRP78,砍和 caspase-12 ) ,在 cardiomyocytes 提高 SIRT1 和 Bcl-2/Bax 比率的表示。有 SIRT1 特定的禁止者 Ex-527 的 cardiomyocytes 的合作处理(1 μ mol/L ) 堵住了导致 SFN 的 cardioprotective effects.Conclusion : SFN 经由激活 SIRT1 小径并且随后禁止 ER 压力依赖者 apoptosis 很可能在 vitro 阻止 cardiomyocytes H/R 损害。 | Yun-peng LI Shu-lin WANG Bei LIU Lu TANG Rong-ren KUANG Xian-bao WANG Cong ZHAO Xu-dong SONG Xue-ming CAO Xiang WU Ping-zhen YANG Li-zi WANG Ai-hua CHEN | 2016 | Acta Pharmacologica Sinica2016，37，3： | 4 |
| 7 | A consensus linkage map of common carp (Cyprinus carpio L.) to compare the distribution and variation of QTLs associated with growth traits显示文摘The ability to detect and identify quantitative trait loci (QTLs) in a single population is often limited. Analyzing multiple populations in QTL analysis improves the power of detecting QTLs and provides a better understanding of their functional allelic variation and distribution. In this study, a consensus map of the common carp was constructed, based on four populations, to compare the distribution and variation of QTLs. The consensus map spans 2371.6 cM across the 42 linkage groups and comprises 257 microsatellites and 421 SNPs, with a mean marker interval of 3.7 cM/marker. Sixty-seven QTLs affecting four growth traits from the four populations were mapped to the consensus map. Only one QTL was common to three populations, and nine QTLs were detected in two populations. However, no QTL was common to all four populations. The results of the QTL comparison suggest that the QTLs are responsible for the phenotypic variability observed for these traits in a broad array of common carp germplasms. The study also reveals the different genetic performances between major and minor genes in different populations. | ZHENG XianHu KUANG YouYi LV WeiHua CAO DingChen ZHANG XiaoFeng LI Chao LU CuiYun SUN XiaoWen | 2013 | Science China(Life Sciences)2013，56，4： | 4 |
| 8 | Simulation and test of the SLEGS TOF spectrometer at SSRF显示文摘The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear motion.The goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron threshold.The SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 detectors.Geant4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF spectrometer.Under the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be separated.The performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns. | Kai-Jie Chen Long-Xiang Liu Zi-Rui Hao Yu-Gang Ma Hong-Wei Wang Gong-Tao Fan Xi-Guang Cao Hang-Hua Xu Yi-Fei Niu Xin-Xiang Li Xin-Rong Hu Yu-Xuan Yang Sheng Jin Pan Kuang | 2023 | Nuclear Science and Techniques2023，34，3： | 3 |
| 9 | Abnormal brain activity in adolescents with Internet addiction who attempt suicide: an assessment using functional magnetic resonance imaging显示文摘Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents.However,whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown.This observational cross-sectional study enrolled 41 young Internet addicts,aged from 15 to 20 years,from the Department of Psychiatry,the First Affiliated Hospital of Chongqing Medical University,China from January to May 2018.The participants included 21 individuals who attempted suicide and 20 individuals with Internet addiction without a suicidal attempt history.Brain images in the resting state were obtained by a 3.0 T magnetic resonance imaging scanner.The results showed that activity in the gyrus frontalis inferior of the right pars triangularis and the right pars opercularis was significantly increased in the suicidal attempt group compared with the non-suicidal attempt group.In the resting state,the prefrontal lobe of adolescents who had attempted suicide because of Internet addiction exhibited functional abnormalities,which may provide a new basis for studying suicide pathogenesis in Internet addicts.The study was authorized by the Ethics Committee of Chongqing Medical University,China(approval No.2017 Scientific Research Ethics(2017-157))on December 11,2017. | Yan Huang Lu Xu Li Kuang Wo Wang Jun Cao Mu-Ni Xiao | 2020 | Neural Regeneration Research2020，15，8： | 3 |
| 10 | Improved cryopreservation of human embryonic stem cells with trehalose显示文摘 | Wu CF Tsung HC Zhang W J Wang Y Lu JH Tang ZY Kuang YP Jin W Cui L Liu W Cao YL | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 11 | D-A-π-A organic sensitizers containing a benzothiazole moiety as an additional acceptor for use in solar cells显示文摘Three novel triphenylamine-based D-A-π-A-featured dyes (Z1-Z3) have been designed, synthesized and characterized for use in dye-sensitized solar cells. Benzothiazole was incorporated as an additional acceptor, which greatly enhanced the molar extinction coefficient of the dyes. Various conjugated linkers, such as benzene, furan and thiophene, were also introduced to configure the novel D-A-π-A framework in order to prolong electron flow and active transportation. Among all dyes, Z2 containing a thiophene linker exhibited the maximum overall conversion efficiency (η) of 4.16% (Jsc = 9.27 mA cm-2 , Voc = 642 mV, FF = 0.70) under standard global AM 1.5 G solar condition. | ZENG Juan ZHANG TengLong ZANG XuFeng KUANG DaiBin MEIER Herbert CAO DeRong | 2013 | Science China Chemistry2013，56，4： | 2 |
| 12 | Enhanced frameless slotted ALOHA protocol with Markov chains analysis显示文摘In this paper, we propose a novel approach to enhance the performance of frameless slotted ALOHA(SA) protocol. We employ signature codes to help the receiver identify the packets contained in collisions, and use successive interference cancellation(SIC) for packet recovery. We model the proposed scheme as a two-state Markov model represented by a uni-partite graph. We evaluate the throughput,expected delay and average memory size of the proposed scheme, and optimize the proposed scheme to maximize the throughput. We show that the theoretical analysis matches well with simulation results.The throughput and expected delay of the proposed protocol outperform the conventional slotted ALOHA protocol significantly. | Dai JIA Zesong FEI Ming XIAO Congzhe CAO Jingming KUANG | 2018 | Science China(Information Sciences)2018，61，10： | 2 |
| 13 | Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway显示文摘Diabetic nephropathy(DN)is one of the most common complications of diabetes mellitus,which is characterized in renal tubulointerstitial fibrosis(TIF).The current study was designed to investigate the protective effect of Jujuboside A(Ju A)on TIF in type 2 diabetes(T2DM)mice,and explore its underlying anti-fibrosis mechanism.A mouse T2DM model was established using high fat diet(HFD)feeding combined with intraperitoneal injection of streptozotocin(STZ).Then,diabetic mice were treated with Ju A(10,20 and 40 mg·kg^(−1)·d^(−1),i.g.)for 12 weeks.Results showed that administration of Ju A not only down-regulated fasting blood glucose(FBG)levels,but also improved hyperlipidemia and renal function in diabetic mice.Moreover,the reduced ECM accumulation was observed in the renal cortex of Ju A treated diabetic mice,while the TIF progression was also attenuated by Ju A through blocking the epithelial-to-mesenchymal transition(EMT)of renal tubular epithelial cells(RTECs).Further mechanism studies showed that Ju A treatment effectively down-regulated the protein expression and subsequent nuclear translocation of Yin Yang 1(YY1)in the renal cortex of diabetic mice,and reduced the levels of transforming growth factor-β1(TGF-β1)in the serum and renal cortex of Ju A treated mice.According to in vitro studies,the up-regulated YY1/TGF-β1 signaling pathway was restored by Ju A in high glucose(HG)cultured HK-2 cells.Taken together,these findings demonstrated that Ju A can ameliorate the TIF of DN through down-regulating the YY1/TGF-β1 signaling pathway. | LIU Yang-Yang LI Lin JI Bei HAO Shi-Long KUANG Xiao-Feng CAO Xin-Yun YUAN Jia-Yu JIANG Zhen-Zhou QIAN Si-Tong WEI Chu-Jing XU Jing YIN Xiao-Xing LU Qian YANG Ting-Ting | 2022 | Chinese Journal of Natural Medicines2022，20，9： | 2 |
| 14 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 15 | Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography显示文摘BACKGROUND The accurate classification of focal liver lesions(FLLs)is essential to properly guide treatment options and predict prognosis.Dynamic contrast-enhanced computed tomography(DCE-CT)is still the cornerstone in the exact classification of FLLs due to its noninvasive nature,high scanning speed,and high-density resolution.Since their recent development,convolutional neural network-based deep learning techniques has been recognized to have high potential for image recognition tasks.AIM To develop and evaluate an automated multiphase convolutional dense network(MP-CDN)to classify FLLs on multiphase CT.METHODS A total of 517 FLLs scanned on a 320-detector CT scanner using a four-phase DCECT imaging protocol(including precontrast phase,arterial phase,portal venous phase,and delayed phase)from 2012 to 2017 were retrospectively enrolled.FLLs were classified into four categories:Category A,hepatocellular carcinoma(HCC);category B,liver metastases;category C,benign non-inflammatory FLLs including hemangiomas,focal nodular hyperplasias and adenomas;and category D,hepatic abscesses.Each category was split into a training set and test set in an approximate 8:2 ratio.An MP-CDN classifier with a sequential input of the fourphase CT images was developed to automatically classify FLLs.The classification performance of the model was evaluated on the test set;the accuracy and specificity were calculated from the confusion matrix,and the area under the receiver operating characteristic curve(AUC)was calculated from the SoftMax probability outputted from the last layer of the MP-CDN.RESULTS A total of 410 FLLs were used for training and 107 FLLs were used for testing.The mean classification accuracy of the test set was 81.3%(87/107).The accuracy/specificity of distinguishing each category from the others were 0.916/0.964,0.925/0.905,0.860/0.918,and 0.925/0.963 for HCC,metastases,benign non-inflammatory FLLs,and abscesses on the test set,respectively.The AUC(95%confidence interval)for differentiating each category from the others was 0.92(0.837-0.992),0.99(0.967-1.00),0.88(0.795-0.955)and 0.96(0.914-0.996)for HCC,metastases,benign non-inflammatory FLLs,and abscesses on the test set,respectively.CONCLUSION MP-CDN accurately classified FLLs detected on four-phase CT as HCC,metastases,benign non-inflammatory FLLs and hepatic abscesses and may assist radiologists in identifying the different types of FLLs. | Su-E Cao Lin-Qi Zhang Si-Chi Kuang Wen-Qi Shi Bing Hu Si-Dong Xie Yi-Nan Chen Hui Liu Si-Min Chen Ting Jiang Meng Ye Han-Xi Zhang Jin Wang | 2020 | World Journal of Gastroenterology2020，26，25： | 2 |
| 16 | Surgical‐pathologic risk factors of pelvic lymph node metastasis in stage Ib1‐IIb cervical cancer显示文摘 | DONGLIN LI JING CAI YAN KUANG JIN CAO ZEHUA WANG | 2012 | Acta Obstetricia et Gynecologica Scandinavica2012，，7： | 1 |
| 17 | Survival benefit from S-1 as com- pared to fluorouracil in Asian patients with advanced gastrointesti- nal cancer:A meta-analysis显示文摘 | Cao C~Zhang X Kuang M et a/ | 2014 | Cancer Sci2014，105，8： | 1 |
| 18 | Interaction between the Circadian Clock and Chronic Stress显示文摘Life on Earth, ranging from single-celled organisms to more complex mammals, has evolved an internal circadian clock system that allows living organisms to coordinate their physiological processes and biological activities with the environmental day-night cycle^([1]). Therefore, the circadian clock system plays a critical role | KUANG Xiao Dong YU Xin Bo CAO Yuan LI Dong Shui ZHU Hai Yan | 2018 | Biomedical and Environmental Sciences2018，31，9： | 1 |
| 19 | China’s Efforts to Peak Carbon Emissions: Targets and Practice显示文摘According to the statement of President Xi Jinping at the general debate of the 75th session of the United Nations General Assembly,China aims to have CO2 emissions peak before 2030.Regions are the major units undertaking carbon emissions control.The achievement of the national emission peaking target requires the participation of all regions.However,regions still need to rationally judge their peaking targets and paths and enhance their basic capabilities while promoting carbon emissions peak.Besides,China should step up its macro-guidance for regions to peak carbon emissions in terms of top-level design,mechanisms improvement,and overall coordination. | CAO Ying Li Xiaomei YAN Haoben KUANG Shuya | 2021 | Chinese Journal of Urban and Environmental Studies2021，9，1： | 1 |
| 20 | Reactivity study and kinetic evaluation of CuO-based oxygen carriers modified by three different ores in chemical looping with oxygen uncoupling(CLOU)process显示文摘In the chemical looping with oxygen uncoupling(CLOU)process,CuO is a promising material due to the high oxygen carrier capacity and exothermic reaction in fuel reactor but limited by the low melting point.The combustion rate of carbon is faster than the decoupling rate of oxygen carrier(OC).Hence,high temperature tolerance and rapid oxygen release rate of CuO modified by three different ores were investigated in this study.The kinetics analysis of oxygen decoupling with Cu-based oxygen carriers was also evaluated.Results showed that CuO modified by chrysolite had faster oxygen release rate than that of CuO.Limestone showed obvious positive effect on the oxidization process.The selected OCs could keep stable in at least 20 cycles,for about 1200 min.Shrinking core model(SCM)fitted well for the decoupling process in the temperature range of 1123-1223 K.Reduction rate kinetic information may aid in the development of chemical looping with oxygen uncoupling(CLOU)technologies during reactor design and process modeling.Ternary doped copper oxide with chrysolite and limestone could improve the reactivity of CuO in decoupling and coupling process and also improve the high temperature tolerance. | Cao Kuang Shuzhong Wang Ming Luo Jun Zhao | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
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