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| 1 | Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing显示文摘 | Pei-Xiang Ni Xin Ding Yin-Xin Zhang Xue Yao Rui-Xue Sun Peng Wang Yan-Ping Gong Jia-Li Zhou Dong-Fang Li Hong-Long WO Xin Yi Ling Yang Yun Long | 2015 | Chinese Medical Journal2015，，7： | 13 |
| 2 | Downregulated cytotoxic CD8^(+)T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids显示文摘Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood pathogenesis,making it difficult to predict and prevent this disease in clinical settings.Identifying disease-specific signatures at the molecular and cellular levels in both the blood circulation and primary lesions is urgently needed to develop novel biomarkers for risk assessment and therapeutic targets for recurrence-free treatment.There is mounting evidence of immune cell dysregulation in keloid scarring.In this study,we aimed to profile keloid scar tissues and blood cells and found that downregulation of cytotoxic CD8^(+)T cells is a keloid signature in the peripheral blood and keloid lesions.Single-cell RNA sequencing revealed that the NKG2A/CD94 complex was specifically upregulated,which might contribute to the significant reduction in CTLs within the scar tissue boundary.In addition,the NKG2A/CD94 complex was associated with high serum levels of soluble human leukocyte antigen-E(sHLA-E).We subsequently measured sHLA-E in our hospital-based study cohort,consisting of 104 keloid patients,512 healthy donors,and 100 patients with an interfering disease.The sensitivity and specificity of sHLA-E were 83.69%(87/104)and 92.16%(564/612),respectively,and hypertrophic scars and other unrelated diseases exhibited minimal interference with the test results.Furthermore,intralesional therapy with triamcinolone combined with 5-fluorouracil drastically decreased the sHLA-E levels in keloid patients with better prognostic outcomes,while an incomplete reduction in the sHLA-E levels in patient serum was associated with higher recurrence.sHLA-E may effectively serve as a diagnostic marker for assessing the risk of keloid formation and a prognostic marker for the clinical outcomes of intralesional treatment. | Heng Xu Zhu Zhu Jian Hu Jiawei Sun Yan Wo Xianshu Wang Hongzhi Zou Bin Li Yixin Zhang | 2022 | Cellular & Molecular Immunology2022，19，4： | 3 |
| 3 | Abnormal brain activity in adolescents with Internet addiction who attempt suicide: an assessment using functional magnetic resonance imaging显示文摘Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents.However,whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown.This observational cross-sectional study enrolled 41 young Internet addicts,aged from 15 to 20 years,from the Department of Psychiatry,the First Affiliated Hospital of Chongqing Medical University,China from January to May 2018.The participants included 21 individuals who attempted suicide and 20 individuals with Internet addiction without a suicidal attempt history.Brain images in the resting state were obtained by a 3.0 T magnetic resonance imaging scanner.The results showed that activity in the gyrus frontalis inferior of the right pars triangularis and the right pars opercularis was significantly increased in the suicidal attempt group compared with the non-suicidal attempt group.In the resting state,the prefrontal lobe of adolescents who had attempted suicide because of Internet addiction exhibited functional abnormalities,which may provide a new basis for studying suicide pathogenesis in Internet addicts.The study was authorized by the Ethics Committee of Chongqing Medical University,China(approval No.2017 Scientific Research Ethics(2017-157))on December 11,2017. | Yan Huang Lu Xu Li Kuang Wo Wang Jun Cao Mu-Ni Xiao | 2020 | Neural Regeneration Research2020，15，8： | 3 |
| 4 | Can we early diagnose metabolic syndrome using brachial-ankle pulse wave velocity in community population?显示文摘 | Li Xin Zheng Liang Wu Juanli Ma Yunsheng Masanori Munakata Oleski Jessica Zhang Lijuan Wo Da Wang Jingsong Jiang Qiaoyu Zou Liling Liu Xuebo Li Jue | 2014 | Chinese Medical Journal2014，，17： | 3 |
| 5 | Antigen-binding characteristics of AbCD71 and its inhibitory effect on PHA-induced lymphoproliferation显示文摘瞄准:调查准备 recombinant 的 anti-lymphoproliferative 效果 71 单音的同种细胞的抗体(AbCD71 ) 它是创作了的区别(CD ) 的妄想的人 / 鼠科的反簇导出老鼠,抗原绑定变量区域和导出人的经常的区域。方法:在原生质标志建设和 transfection 以后,在 transfectoma 上层清液的 AbCD71 的表示被三明治 ELISA 决定。间接免疫荧光试金被用来测量抗原绑定特征和百分比表示 CD71 的外部血单音的原子房间(PBMC ) 。抗体经由 diethylaminoethyl (DEAE ) 从腹水被净化 -Sephadex A-50 层析然后由 SDS 页识别了。最后,导致公众房产管理局的 PBMC 增长上的 AbCD71 的禁止的效果被甲基 thiazolyl tetrazolium (MTT ) 计算试金。结果:重链(C (H)) 和 AbCD71 的轻链(C (L)) 的经常的领域分别地在人的 Cgamma 家庭和人的 Ckappa 家庭。AbCD71 能与它的原来的鼠科的 mAb 竞争与 CD71 积极的人的白血病房间线 CEM 房间绑。AbCD71 能禁止单音的原子房间增长由 phytohemagglutinin (公众房产管理局) 导致了的外部血以一种剂量依赖者方式的在试管内,特别在时间点 0 和 12 h 在以后感应。没有统计差别什么时候与原来的鼠科的 mAb 相比。结论:AbCD71 是有希望的抑制免疫力的药。我们与妄想的人 / 鼠科的 mAb 堵住 CD71 的途径为延长紧密相联的接枝幸存提供新奇策略。 | Ping LEI Yong HE Qing YE Hui-fen ZHU Xiao-mei YUAN Jing LIE Wei XING Sha WO Wei DAI Xin SHEN Guo-bin WANG Guan-xin SHEN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 6 | Synthesis and platelet aggregation inhibitory effects of harman and phthalide derivatives related to Ligusticum Chuanxion(Hort)conatituents显示文摘 | Foye WO Wa ng X Wang H | 1997 | Med Chem Res1997，7，3： | 1 |
| 7 | TREM-1 is a positive regulator of TNF- alphaand IL-8 production in U937 foam ceils 显示文摘 | Wang YS Li XJ Zhao WO | 2012 | Bosn J Basic Mcd Sci2012，12，2： | 1 |
| 8 | Chem Res Toxieol显示文摘 | Behnia K Cornelius G Wang J Shipkova P Johnghar S Washburn W Brigance R Stetsko P Henwood A Wo)ciec- howski J P Marathe P Rodrigues A D Humphreys W G | 2011 | 24(6) :9052011，24，6： | 1 |
| 9 | The RNA component of human telomerase 显示文摘 | Feng J Funk WO Wang SS | 1995 | Science1995，269，： | 1 |
| 10 | Molecular epidemiology of human rhi- novirus in children with acute respiratory diseases in chongqing, China 显示文摘 | Lu QB Wo Y Wang HY | 2014 | Sci Rep2014，4，： | 1 |
| 11 | A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to SiWu Tang 显示文摘 | Wang L Wang Z J Wo S | 2011 | Int JPharm2011，406，12： | 1 |
| 12 | Selected topics on lymphoid lesions in the head and neck regions 显示文摘 | Greaves WO Wang SA | 2011 | Head Neck Pathol2011，5，1： | 1 |
| 13 | A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines,application to Si Wu Tang显示文摘 | Wang L Wang Z Wo S | 2011 | Int J Pharm2011，406，12： | 1 |
| 14 | The preparation and characterization of novel charged polyacrylonitrile/PES-C blend membranes used for ultrafiltration显示文摘 | Wang M Wo L G Mo J X | 2006 | J Membr Sci2006，274，： | 1 |
| 15 | Phase II study of capecitabine and cisplatin combination as first -line chemotherapy in Chinese pa- tients withmetastatic nasopharyngeal carcinoma 显示文摘 | Li YH Wang FH Jiang WO | 2008 | Cancer Che- mother Pharmacol2008，62，3： | 1 |
| 16 | Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer ceils 显示文摘 | Arafat WO Casado E Wang M | 2000 | Clin Cancer Res2000，6，11： | 1 |
| 17 | Malakoplakia of the spleen: a case report 显示文摘 | Greaves WO Wang LJ | 2010 | Int J Surg Pathol2010，18，6： | 1 |
| 18 | Simultaneous quantication of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography mass spectrometry显示文摘 | Wang ZJ Wo SK Wang L | 2009 | J Pharm Biomed2009，50，2： | 1 |
| 19 | A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chineses medicine,application to Si Wu Tang显示文摘 | Wang L Wang Z J Siukwan Wo | | 0，，406： | 1 |
| 20 | Partial protection against malaria by immunization with Leishmania enriettii expression the Plasmodium yoelii circumsporozoite protein显示文摘 | Wang HH Rogers WO Kang YH | 1995 | Mol Biochem Parasitol1995，69，2： | 1 |
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