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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Correct formulation of theKappa coefficient of agreement显示文摘 | William D H Carl W R | | 0，，04： | 1 |
| 4 | Advances in modeling the effects of selected parameters on the SLS显示文摘 | John D W Carl R D | 1998 | Rapid Prototyping Journal1998，4，2： | 1 |
| 5 | Device-to-device com- munication as an underlay to LTE-advanced networks显示文摘 | KLAUS D MIKA R CARL W | 2009 | IEEE Communications Magazine2009，47，12： | 1 |
| 6 | Thr2446 is a novel mammalian target of rapamycin (roTOR) phosphofy- lation site regulated by nutrient status 显示文摘 | CHENG S W FRYER L G CARLING D | 2004 | J Biol Chem2004，279，15： | 1 |
| 7 | Growth and body composition of channel catfish (Ictalurus punctatus)fed diets containing various percentages of canola meal显示文摘 | Carl D W Laura G T James H T John M G | 1996 | Aquaculture1996，103，： | 1 |
| 8 | The theory of diffraction-limited resolution in microparticle image velocimetry显示文摘 | CARL D M STEVEN T W | 2003 | Measurement science and technology2003，14，7： | 1 |
| 9 | Correct formulation of the kappa coefficient of agreement显示文摘 | William D H Carl W R | 1987 | Photogram metric Engineering and Remote Sensing1987，53，4： | 1 |
| 10 | Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status显示文摘 | Cheng S W Y Fryer L G D Carling D | 2004 | Journal of Biological Chemistry2004，279，16： | 1 |
| 11 | Anastomosis group (AG) affinity of pectic isozyme ( zymogram)groups (ZG) of Rhizoctonia solani from the Western Australiancereal-belt显示文摘 | Macnish G C Carling D E Sweetingham M W | 1994 | Mycol Res1994，98，12： | 1 |
| 12 | Imidazopyrazin-8-ones,imidazotriazin-8-ones and imidazotriazin-8-ones as a2/a3 subtypeselective GABAA agonists for the treatment of anxiety显示文摘 | Goodacre S C Haller D J Carling R W | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 13 | A plastid phylogeny of the Cosmopolitan fern family Cystopteridaceae (Polypodiopsida) 显示文摘 | CARL J R MICHAEL D W KATHLEEN M P | 2013 | Systematic Botany2013，38，2： | 1 |
| 14 | Social Entrepreneurship: A Content Analysis 显示文摘 | Cukier W C Trenholm S Carl D & Gekas G | 2011 | Journal of Strategic Innovation and Sustainability2011，，01： | 1 |
| 15 | Device-to-device communication as an underlay to LTE-advanced networks 显示文摘 | KLAUS D MIKA R CARL W | 2009 | IEEE Communications Magazine2009，47，12： | 1 |
| 16 | Thr 2446 is a novel mammamlian target of rapamycin (mTOR) phosphoryla-tion site regulated by nutrient status显示文摘 | Cheng S W Fryer L G Carling D | 2004 | J Biol Chem2004，279，15： | 1 |
| 17 | Interactions of arbuscular mycorrhizae, Meloidogyne arenada, and phosphorus fertilization on peanut显示文摘 | Carling D E Roncadori R W Hussey R S | 1996 | Mycorrhiza1996，，6： | 1 |
| 18 | Thr2446 is a novel mammalian target of rapamyein (mTOR) phosphorylation site regulated by nutrient status显示文摘 | Cheng S W Fryer L G Carling D | 2004 | J Biol Chem2004，279，15： | 1 |
| 19 | Interactions of arbuscular mycorrhizae,Meloidogyne arenaria,and phosphorus fertilization on peanut显示文摘 | Carling D E Roncadori R W Hussey R S | 1996 | Mycorrhiza1996，6，： | 1 |
| 20 | Thr 2446 is a novel mammamlian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status显示文摘 | Cheng S W Fryer L G Carling D | 2004 | J Biol Chem2004，279，15： | 1 |
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