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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | Novel ion exchange chromato-graphic method using conductimetric detection显示文摘 | Small H Stevens T Bauman W | | 0，，11： | 1 |
| 4 | 查看详情显示文摘 | Small H Stevens T S Bauman W C | | 0，，： | 1 |
| 5 | Visibility and aerosol composition in Houston,Texas显示文摘 | Dzubay T G Stevens R K Lewis C W | 1982 | Environ Sci Technol1982，16，8： | 1 |
| 6 | Controllable Surface Modification of Poly( lactic-co-glycolicacid) (PLGA) by Hydrolysis or Aminolysis I: Physical,Chemical, and Theoretical Aspects显示文摘 | Croll T I O'Connor A J Stevens G W Cooper-White J J | 2004 | Biomacromolecules2004，5，2： | 1 |
| 7 | Within-stand spatial structure and relation of boreal canopy and understorey vegetation显示文摘 | Kembel Steven W Dale Mark R T | 2006 | Journal of Vegetation Science2006，17，： | 1 |
| 8 | Self-organization of large gold nanoparticle arrays显示文摘 | Beomseok K Steven L T Alexander W | 2001 | J Am Chem Soc2001，12，3： | 1 |
| 9 | Singularities of principal Direction Fields from 3-D Images 显示文摘 | Sander Peter T Zucker Steven W | 1992 | IEEE Trans1992，14，3： | 1 |
| 10 | Aerosol properties over bright-reflecting source region显示文摘 | Dzubay T G Stevens R K Lewis C W | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，3： | 1 |
| 11 | Bibliometric analysis on Australian rural healthpublications from 2006 to 2012显示文摘 | Mendis K Edwards T Stevens W McCrossin T | 2014 | The Australianjournal of rural health2014，22，4： | 1 |
| 12 | Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas显示文摘 | Michelle A Anderson Steven Carpenter Norman W Thompson Timothy T Nostrant Grace H Elta James M Scheiman | 2000 | The American Journal of Gastroenterology2000，，9： | 1 |
| 13 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 1 |
| 14 | Evaluation of the nu-cliSens easyQ assay in HIV-1-infected individuals in South Africa显示文摘 | Stevens W Wiggill T Horsfield P | 2005 | J Viro Meth2005，124，： | 1 |
| 15 | Novel ion exchange chromatographic method显示文摘 | SMALL H STEVENS T S BAUMANN W C | 1975 | Anal Chem1975，47，： | 1 |
| 16 | Diamond retention in sintered cobalt bonds for stone cutting and drilling显示文摘 | Steven W Webb T | 1999 | Diamond and Related Materials1999，8，11： | 1 |
| 17 | Novel ion exchange chromatographic method using conductimetrie detection 显示文摘 | Small H Stevens T Baunann W | 1975 | Analytic al Chemistry1975，47，11： | 1 |
| 18 | EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors 显示文摘 | Stevens L Zhang W Peck L Kuczek T Grevstad N Mahon A | 2003 | Lipids2003，38，10： | 1 |
| 19 | Development of transition edge sensor gamma-ray detectors for positron-annihilation-spectroscopy显示文摘 | Steven W L Hiroyuki T | 2008 | J Low Temperature Phys2008，151，34： | 1 |
| 20 | The theory of diffraction-limited resolution in microparticle image velocimetry显示文摘 | CARL D M STEVEN T W | 2003 | Measurement science and technology2003，14，7： | 1 |
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