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| 1 | Noninvasive diagnosis of hepatic fibrosis in chronic hepatitis C显示文摘Assessment of hepatic fibrosis is important for determining prognosis,guiding management decisions,and monitoring disease. Histological evaluation of liver biopsy specimens is currently considered the reference test for staging hepatic fibrosis. Since liver biopsy carries a small but significant risk,noninvasive tests to assess hepatic fibrosis are desirable. This editorial gives an overview on noninvasive methods currently available to determine hepatic fibrosis and their diagnostic accuracy for predicting significant fibrosis and cirrhosis in chronic hepatitis C. Based on available data,the performance of simple tests derived from routine laboratory parameters appears to be similar to that of more complex and expensive fibrosis panels. Transient elastography seems more accurate than blood tests for diagnosing cirrhosis. | Rudolf E Stauber Carolin Lackner | 2007 | World Journal of Gastroenterology2007，13，32： | 5 |
| 2 | Hepatotoxicity of NONI juice: Report of two cases显示文摘NONI juice (Morinda citrifolia) is an increasingly popular wellness drink claimed to be beneficial for many illnesses.No overt toxicity has been reported to date. We present two cases of novel hepatotoxicity of NONI juice. Causality of liver injury by NONI juice was asses-sed. Routine laboratory tests and transjugular or percutaneous liver biopsy were performed. The first patient underwent successful liver transplantation while the second patient recovered spontaneously after cessation of NONI juice.A 29-year-old man with previous toxic hepatitis associated with small doses of paracetamol developed sub-acute hepatic failure following consumption of 1.5 L NONI juice over 3 wk necessitating urgent liver transplantation. A 62-year-old woman without evidence of previous liver disease developed an episode of self-limited acutehepatitis following consumption of 2 L NONI juice for over 3 mo. The most likely hepatotoxic components of Morinda citrifolia were anthraquinones. Physicians should be aware of potential hepatotoxicity of NONI juice. | Vanessa Stadlbauer Peter Fickert Carolin Lackner Jutta Schmerlaib Peter Krisper Michael Trauner Rudolf E Stauber | 2005 | World Journal of Gastroenterology2005，11，30： | 3 |
| 3 | Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival显示文摘 | Karl Oettl Ruth Birner-Gruenberger Walter Spindelboeck Hans Peter Stueger Livia Dorn Vanessa Stadlbauer Csilla Putz-Bankuti Peter Krisper Ivo Graziadei Wolfgang Vogel Carolin Lackner Rudolf E. Stauber | 2013 | Journal of Hepatology2013，，5： | 1 |
| 4 | Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine显示文摘 | Marin E. Healy Jenny D.Y. Chow Frances L. Byrne David S. Breen Norbert Leitinger Chien Li Carolin Lackner Stephen H. Caldwell Kyle L. Hoehn | 2014 | Journal of Hepatology2014，，： | 1 |
| 5 | Effects of N-3 Fish Oil on Metabolic and Histological Parameters in NASH: A Double-Blind, Randomized, Placebo-Controlled Trial显示文摘 | Curtis K. Argo James T. Patrie Carolin Lackner Thomas D. Henry Eduard E. deLange Arthur L. Weltman Neeral L. Shah Abdullah M. Al-Osaimi Patcharin Pramoonjago Saumya Jayakumar Lukas P. Binder Winsor D. Simmons-Egolf Sandra G. Burks Yongde Bao Anne Gill Tay | 2014 | Journal of Hepatology2014，，： | 1 |
| 6 | Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M显示文摘AIM To investigate the influence of PNPLA3 genotype in heavy drinkers on serum markers and liver stiffness(LS) during alcohol withdrawal and its association with histology.METHODS Caucasian heavy drinkers(n = 521) with a mean alcohol consumption of 192.1 g/d(median alcohol consumption: 169.0 g/d; 95%CI: 179.0-203.3) were enrolled at the Salem Medical Center, University of Heidelberg. LS was measured by transient elastography(Fibroscan, Echosens SA, Paris, France). LS and serum markers were prospectively studied in these patients with all stages of alcoholic liver disease(steatosis, steatohepatitis, fibrosis) prior and after alcohol detoxification with a mean observation interval of 6.2 ± 3.2 d. A liver biopsy with histological analysis including the Kleiner score was obtained in 80 patients.RESULTS The PNPLA3 rs738409 genotype distribution for CC, CG and GG was 39.2%, 52.6% and 8.2%. GG genotype primarily correlated with histological steatohepatitis(r = 0.404, P < 0.005), ballooning(r = 0.319, P < 0.005) and less with steatosis(r = 0.264, P < 0.05). Mean LS was lowest in CC carriers(13.1 k Pa) as compared to CG and GG carriers(17.6 and 17.2 kPa). Notably, LS primarily correlated with fibrosis stage(r = 0.828, P < 0.005), ballooning(r = 0.516, P < 0.005), steatohepatitis(r = 0.319, P < 0.005) but not with steatosis. After alcohol withdrawal, LS did not change in CC carriers, significantly decreased in CG-carriers from 17.6 to 12.7 kPa but to a lesser extent in GG carriers from 17.6 to 14.5 kPa. This was due to prolonged resolution of inflammation with significantly elevated aspartate transaminase levels after alcohol withdrawal in GG carriers. Non-invasive fibrosis assessment by LS in all patients showed a significantly higher F0 rate as compared to the biopsy cohort(47% vs 6%) with 3.8% more CC carriers while 3.7% less were seen in the F4 cirrhosis group. Thus, about 20% of patients with alcoholic liver cirrhosis would be attributable to PNPLA3 G variants. The OR to develop cirrhosis corrected for age, gender and body mass index was 1.295(95%CI: 0.787-2.131) for CG + GG carriers.CONCLUSION In heavy drinkers, PNPLA3 GG primarily correlates with ballooning/steatohepatitis but not steatosis resulting in a delayed inflammation-associated resolution of LS. Consequently, sustained ballooning-associated LS elevation seems to be a potential risk factor for fibrosis progression in PNPLA3 GG carriers. | Vanessa Rausch Teresa Peccerella Carolin Lackner Eray Yagmur Helmut-Karl Seitz Thomas Longerich Sebastian Mueller | 2016 | World Journal of Hepatology2016，8，35： | 1 |
| 7 | Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)显示文摘 | Pooja Jha Astrid Knopf Harald Koefeler Michaela Mueller Carolin Lackner Gerald Hoefler Thierry Claudel Michael Trauner | 2014 | BBA - Molecular Basis of Disease2014，，： | 1 |
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