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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Novel α- and -amino acid inhibitors of influenza virus neuraminidase 显示文摘 | Kati W M Montgomery D Maring C | 2001 | Antimicrob Agents Chemother2001，45，9： | 3 |
| 3 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 4 | Observation of hearing loss in pa- tients with chronic suppurative otitis media tubotympanic type 显示文摘 | Maharjan M Katie P Bista M | 2009 | Kathmandu Univ Med J (KUMJ)2009，7，28： | 1 |
| 5 | A closterovirus (family: Closteroviridae) isolated from tobacco crops in Northern Greece (Macedonia)显示文摘 | Chatzivassiliou E K Katis N I Tchomguia M | 1999 | Plant Disease1999，83，： | 1 |
| 6 | Integration of Remote Sensing and GIS with Flood Simulation Model for Flood Hazard Mapping in the Bafmati River, NEPAL 显示文摘 | Katie T P Hazarika M K Shrestha K G | 2006 | New Technologies for Urban Safety of Mega cities in Asia2006，，： | 1 |
| 7 | The BOVIG- AM assay as ancillary test to the Tuberculin skin test 显示文摘 | Vordermeier M Katie Ewer A W Goodchild T | 2006 | Govern- ment Veterinary Journal2006，16，1： | 1 |
| 8 | The accuracy of ultrasound - estimated fetal weight in extremely preterm infants:a comparison of small for gestational age and appropriate for gestational age 显示文摘 | STEFANELLI S KATIE M G | 2014 | The Australian & New Zealand Journal of Obstetrics &Gynaecolagy2014，54，2： | 1 |
| 9 | Phylogenetie analysis of en- terovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia 显示文摘 | Peter M Katie L David P | 2001 | J Virol2001，75，16： | 1 |
| 10 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 11 | Mammary Gland Immunity and Mastitis Susceptibility显示文摘 | Lorraine M Sordillo Katie L S | 2002 | Journal of Mammary Gland Biology and Neoplasia2002，，7： | 1 |
| 12 | Heart disease in thalassemia intermedia:a review of the underlying pathophysiology显示文摘 | Aessopos A Kati M Farmakis D | | 0，，： | 1 |
| 13 | Sustainable land reuse:the influence of different stakeholders in achieving sustainable brownfield developments in England显示文摘 | Carol M Dair Katie Williams | 2006 | Environment and Planning A2006，38，7： | 1 |
| 14 | The effect of EDTA and citric acid on phytoremediation of Cd,Cr and Ni from soil using Helianthus annuus显示文摘 | Cafer Turgut Katie Pepe M Teresa Cutright J | 2004 | Environmentalpollution2004，131，： | 1 |
| 15 | Gene expression in TGFheta - induced epithelial cell differentiation in a three- dimensional intestinal epithelial cell differentiation model显示文摘 | Kati M Juuti - Uusitalo Katri Kaukinen Jarno Tuimala | 2006 | BMC Enomies2006，7，： | 1 |
| 16 | A Case Study of Organizational Capac- ity in Nonprofit Community Sport 显示文摘 | Katie M Alison D | 2009 | Journal of Sport Man- agement2009，，45： | 1 |
| 17 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 18 | Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart显示文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases. | Anastasios Lymperopoulos Shelby L Wertz Celina M Pollard Victoria L Desimine Jennifer Maning Katie A McCrink | 2019 | World Journal of Cardiology2019，11，2： | 1 |
| 19 | Characterization of crystalline cellulose in biomass: basic principles, applications, and limitations of XRD, NMR, IR, Raman, and SFG显示文摘 | Kim S H Lee C M Katie K | 2013 | Korean Journal Chemistry Engineering2013，30，12： | 1 |
| 20 | Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil显示文摘 | Katie S Nilofer P Steven M | 2008 | Randall FASEB J2008，，： | 1 |
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