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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 3 | Tenderness-An enzymatic view显示文摘 | Caroline M K Paul L S Ronald G B | 2010 | Meat Science2010，84，： | 1 |
| 4 | Development and valida- tion of methods for the trace determination of phthalates in sludge and vegetables显示文摘 | Caroline S Mireille M David B | 2005 | J Chromatogr A2005，1072，2： | 1 |
| 5 | Zolmitriptan显示文摘 | Caroline M Spencer Nishan S Gunasekara Carol Hill s | 1999 | Drugs1999，58，2： | 1 |
| 6 | DNA-DNA cross-links contribute to the mutagenic potential of the mycotoxin patulin显示文摘 | David M S Carolin M Manfred M | 2006 | Toxicol Lett2006，166，3： | 1 |
| 7 | Comparing uncertain alternatives for a possible airport island location in the North Sea显示文摘 | Caroline S K Suzanne J M H H Teunis L | 2003 | Ocean & Coastal Management2003，46，1112： | 1 |
| 8 | Eosinophilic fasciitis :a rare skin sclerosis 显示文摘 | Amandiue S Thierry C Caroline M | 2010 | Pathology Research International2010，2011，71： | 1 |
| 9 | A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity 显示文摘 | Michael M S Caroline M L C Brendan M M | 2001 | Eur J Endocrinol2001，144，： | 1 |
| 10 | ALLENEOXIDE CYCLASE (AOC) gene family members of Arabidopsis thaliana : tissue-and organ-spe- cific promoter activities and in vivo heteromerization显示文摘 | IRENE S OTTO M CAROLIN D | 2012 | J Exp Bot2012，63，17： | 1 |
| 11 | Zolmitriptan 显示文摘 | CAROLINE M SPENCER NISHAN S GUNASEKARA CAROL HILLS | 1999 | Drugs1999，58，2： | 1 |
| 12 | High-Mobility Group Box 1 Contributes to Lethality of Endotoxemia in Heme Oxygenase-1-Deficient Mice显示文摘 | Takamiya Rina Hung Chi-Chih Hall Sean R Fukunaga Koichi Nagaishi Takashi Maeno Toshitaka Owen Caroline Macias Alvaro A Fredenburgh Laura E Ishizaka Akitoshi Blumberg Richard S Baron Rebecca M Perrella Mark A | 2009 | American Journal of Respiratory Cell and Molecular Biology2009，，2： | 1 |
| 13 | Electron transfer in syntrophic communities of anaerobic bacteria and archaea 显示文摘 | ALFONS J M S CAROLINE M P | 2009 | Nature Reviews Microbiology2009，7，： | 1 |
| 14 | Combinatorial control of Arabidopsis dehydrogenase transcription by specific heterodimerisation of bZIP transcription factors显示文摘 | Fridtjof W Andrea E Caroline S M | 2006 | The EMBO Journal2006，25，： | 1 |
| 15 | Trends in U.S. Consumers’ Safe Handling and Consumption of Food and Their Risk Perceptions, 1988 through 2010显示文摘 | Fein Sara B Lando Amy M Levy Alan S Teisl Mario F Noblet Caroline | 2011 | Journal of Food Protection2011，，9： | 1 |
| 16 | Comparison of endortoxin exposure assessment by bioaerosol impinger and filter-sampling methods 显示文摘 | CAROLINE D PETER S ANNE M | 2001 | Applied and Environment Microbiology2001，67，6： | 1 |
| 17 | Pharmacists' role in the health caresystem 显示文摘 | Caroline S Z William W M | 2006 | Health Highlights2006，7，1： | 1 |
| 18 | Effectiveness of a protective environ- ment implementation for cancer patients with chemotherapyinduced neu- tropenia on fever and mortality incidence显示文摘 | Paula P Lficia S Caroline M | 2013 | Am J Infect Conn12013，41，4： | 1 |
| 19 | Broad spectrum antiviral activity of favipiravir(T-705):protection from highly lethal inhalational rrift valley fever显示文摘 | Caroline A L Powell D S Bethel L M | 2014 | PLo S Negl Trop Dis2014，8，4： | 1 |
| 20 | Adiposity, Cardiometabolie Risk, and VitaminD Status: the Framinghan Heart Study 显示文摘 | SUSAN CHENG JOSEPH M M CAROLINE S F | 2010 | Diabetes2010，59，1： | 1 |
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