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| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 3 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 4 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 5 | Angiotensin-(1-7) Counterregulates Angiotensin Ⅱ Signaling in Human Endothelial Cells显示文摘 | Sampaio WO Henrique de Castro C Santos RA | 2007 | Hypertension2007，50，6： | 1 |
| 6 | Neutrophil Activation and Resistance to Recombinant Human Erythropoietin Therapy in Hemodialysis Patients显示文摘 | Costa Elísio Rocha Susana Rocha-pereira Petronila Nascimento Henrique Castro Elisabeth Miranda Vasco Do Sameiro Faria Maria Loureiro Alfredo Quintanilha Alexandre Belo Luís Santos-silva Alice | 2008 | American Journal of Nephrology2008，，6： | 1 |
| 7 | Angiotensin-( 1 -7) counterregulates angioten-sin II signaling in human endothelial cells 显示文摘 | SAMPAIO W 0 HENRIQUE D E CASTRO C SANTOSR A | 2007 | Hyperten-sion2007，50，6： | 1 |
| 8 | Neural Networks for Short-Term Load Forecasting:A Review and Evaluation 显示文摘 | Henrique Steinherz Hippert Calos Eduardo Pedreira and Reinaldo Castro Souza | 2001 | IEEE Transaction on Power Systems2001，16，1： | 1 |
| 9 | Obstructive Sleep Apnea and P300 Evoked Auditory Potential显示文摘 | Carlos Henrique Martins Ney de Castro Orozimbo Alves Costa Filho Osmar Mesquita de Souza Neto | 2011 | Brazilian Journal of Otorhinolaryngology2011，，6： | 1 |
| 10 | Neural Networks for Short-Term Load Forecasting:A Review and Evaluation显示文摘 | Henrique Steinherz Hippert Carlos Eduardo Pedreira Reinaldo Castro Souza | | 0，，： | 1 |
| 11 | Neural networks for short-term load forecasting:A review and evaluation显示文摘 | Henrique Steinherz Hippert Carlos Eduardo Pedreira Reinaldo Castro Souza | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 12 | Proteomic survey of the pathogenic Mycoplasma hyopneumoniae strain 7448 and identification of novel post-translationally modified and antigenic proteins显示文摘 | Paulo Marcos Pinto Gustavo Chemale Luiza Amaral de Castro Ana Paula Metz Costa Jalusa Deon Kich Marilene Henning Vainstein Arnaldo Zaha Henrique Bunselmeyer Ferreira | 2006 | Veterinary Microbiology2006，，1： | 1 |
| 13 | Effects of a cosurfactant on the shear- dependent structures of systems composed of biocompatible ingredients显示文摘 | Rejane de Castro Santana Lui Henrique Fasolin Rosiane Lopes da Cunha | 2012 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2012，398，： | 1 |
| 14 | Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells显示文摘 | Sampaio WO Henrique de Castro C Santos RA | 2007 | Hypertension2007，50，6： | 1 |
| 15 | Impact of preformed donor-specific antibodies against HLA class Ⅰ on kidney graft outcomes:Comparative analysis of exclusively anti-Cw vs anti-A and/or-B antibodies显示文摘AIM To analyze the clinical impact of preformed antiH LA-Cw vs antiH LA-A and/or-B donor-specific antibodies(DSA) in kidney transplantation.METHODS Retrospective study, comparing 12 patients transplanted with DSA exclusively antiH LA-Cw with 23 patients with preformed DSA antiH LA-A and/or B.RESULTS One year after transplantation there were no differencesin terms of acute rejection between the two groups(3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1). At one year, eG FR was not significantly different between groups(median 59 mL /min in DSA-Cw group, compared to median 51 mL /min in DSA-A-B group, P = 0.192). Moreover, kidney graft survival was similar between groups at 5-years(100% in DSA-Cw group vs 91% in DSA-A-B group, P = 0.528). The sole independent predictor of antibody mediated rejection(AMR) incidence was DSA strength(HR = 1.07 per 1000 increase in MFI, P = 0.034). AMR was associated with shortened graft survival at 5-years, with 75% and 100% grafts surviving in patients with or without AMR, respectively(Log-rank P = 0.005).CONCLUSION Our data indicate that DSA-Cw are associated with an identical risk of AMR and impact on graft function in comparison with 'classical' class I DSA. | Sofia Santos Jorge Malheiro Sandra Tafulo Leonídio Dias Rute Carmo Susana Sampaio Marta Costa Andreia Campos Sofia Pedroso Manuela Almeida La Salete Martins Castro Henriques António Cabrita | 2016 | World Journal of Transplantation2016，6，4： | 1 |
| 16 | Aesthetic Refinements in Breast Augmentation with Deep Inferior Epigastric Perforator Flap: A Case Report显示文摘 | Alexandre Mendon?a Munhoz Luis Henrique Ishida Gustavo Gibin Duarte Marcelo Sacramento Cunha Eduardo Montag Gustavo Sturtz Rolf Gemperli Marcus Castro Ferreira | 2003 | Aesthetic Plastic Surgery2003，，2： | 1 |
| 17 | Neural Networks for Short-Term Load Forecasting:A Review and Evaluation 显示文摘 | Henrique Steinherz Hippert Calos Eduardo Pedreira and Reinaldo Castro Souza | 2001 | IEEE Transaction on Power Systems2001，16，1： | 1 |
| 18 | Angiotensin-(1-7) eounterregulates angiotensin II signaling inhumanendothelial cells 显示文摘 | Sampaio W O Henrique de Castro C Santos R A Schiffrin E L Touyz R M | 2007 | Hypertension2007，50，： | 1 |
| 19 | Neural networks for short-term load forecasting: a review and evaluation显示文摘 | HENRIQUE Steinherz Hippert CARLOS Eduardo Pedreira REINALDO Castro Souza | 2001 | IEEE Transac- tions on Power Systems2001，16，1： | 1 |
| 20 | Angio- tensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells 显示文摘 | Sampaio WO Henrique De Castro C Santos RA et ol | 2007 | Hypertension2007，50，6： | 1 |
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