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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | DHA supplementation im- proved both memory and reaction time in healthy young aduhs:a ran- domized controlled trial显示文摘 | WELMA S CATHRYN A C JOHN P | 2013 | Am J Clin Nutr2013，，： | 1 |
| 4 | Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome显示文摘 | Melissa R Cathryn SM Catherine A | 2001 | J Biochem Biophys Methods2001，47，： | 1 |
| 5 | recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo 显示文摘 | Christina A Cathryn S Bijoy D | 2006 | Circu Res2006，99，： | 1 |
| 6 | Iron status and self-perceived health, well-being, and fatigue in female university students living in new zealand 显示文摘 | Kathryn L Beck Cathryn A Conlon Rozanne Kruger | 2012 | Journal of the American College of Nutrition2012，31，1： | 1 |
| 7 | Inhibition of HIV-1 Ribonudease H by a novel diketo acid, 4--2, 4-dioxobutanoic Acid显示文摘 | CATHRYN A SHAW-REID MUNSHI V | 2003 | The Journal of Biological Chemistry2003，278，5： | 1 |
| 8 | Delivery of avian cytokines by adenovirus vectors显示文摘 | Michael A J Cathryn P John W L | 2000 | Dev Comp Immunol2000，24，： | 1 |
| 9 | Effects of high pressure processing on antioxidant activity, and total carotenoid content and availability, in vegetables显示文摘 | Jennifer K Mclnerney Cathryn A | 2007 | Innovative Food Science and Emerging Technologies2007，8，： | 1 |
| 10 | Comprehensive geriatric assessment:making the mostof the aging years显示文摘 | Devons Cathryn A | 2002 | Curr Opin Clin Nutr Metab Care2002，5，： | 1 |
| 11 | Dietary determinants of and possible solution to Iron deficiency for young women living in industrialized countries:a review显示文摘 | KATHRYN L B CATHRYN A C ROZANNE K | 2014 | Nutrients2014，6，9： | 1 |
| 12 | Effects of high pressure processing on antioxidant activity, and total carotenoid content and availability,in vegetables显示文摘 | Jennifer K Melnemey Cathryn A Seccafien Cynthia M Stewart eta! | 2007 | Innovative Food Science and Emerging Technologies2007，8，4： | 1 |
| 13 | Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo显示文摘 | Christina A Cathryn S Bijoy D | 2006 | Circu Res2006，99，： | 1 |
| 14 | The anaerobic degradability of thermoplastic starch: Polyvinyl alcohol blends: Potential biodegradable food packaging materials显示文摘 | Melissa A L Russo Cathryn O' Sullivan Beth Rounsefell | 2009 | Bioresource Technology2009，100，5： | 1 |
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