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| 1 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 2 | Grain yield and water use of winter wheat as affected by water and sulfur supply in the North China Plain显示文摘Water shortage has threatened sustainable development of agriculture globally as well as in the North China Plain(NCP).Irrigation,as the most effective way to increase food production in dry land,may not be readily available in the situation of drought.One of the alternatives is to supply plants with enough nutrients so that they can be more sustainable to the water stress.The objective of this study was to explore effects of irrigation and sulphur(S)application on water consumption,dry matter accumulation(DMA),and grain yield of winter wheat in NCP.Three irrigation regimes including no irrigation(rainfed,I_0)during the whole growth period,once irrigation only at jointing stage(90 mm,I_1),and twice respective irrigation at jointing and anthesis stages(90 mm plus 90 mm,I_2),and two levels of S application including 0(S_0)and 60 kg ha^(–1)(S_(60))were designed in the field experiment in NCP.Results showed that increasing irrigation times significantly increased mean grain yield of wheat by 12.5–23.7%and nitrogen partial factor productivity(NPFP)by 21.2–45.0%in two wheat seasons,but markedly decreased crop water use efficiency(YWUE).Furthermore,S supply 60 kg ha^(–1) significantly increased mean grain yield,YWUE,IWUE and NPFP by 5.6,6.1,23.2,and 5.6%(across two wheat seasons),respectively.However,we also found that role of soil moisture prior to S application was one of important greater factors on improving the absorption and utilization of storage water and nutrients of soil.Thus,water supply is still the most important factor to restrict the growth of wheat in the present case of NCP,supplying 60 kg ha^(–1) S with once irrigation 90 mm at the jointing stage is a relatively appropriate recommended combination to improve grain yield and WUE of wheat when saving water resources is be considered in irrigated wheat farmlands of NCP. | XIE Ying-xin ZHANG Hui ZHU Yun-ji ZHAO Li YANG Jia-heng CHA Fei-na LIU Cao WANG Chen-yang GUO Tian-cai | 2017 | Journal of Integrative Agriculture2017，16，3： | 6 |
| 3 | High-efficiency plastome base editing in rice with TAL cytosine deaminase显示文摘Dear Editor,Genome editing has been widely applied in nuclei but not so in organelles such as the mitochondria and chloroplasts.The challenge for organelle genome editing is the limited accessibility of editing reagents to the compartments of organelles(Zhu et al.,2020).Recently,fusion proteins of cytidine deaminase domain(DddAtox)and transcription activator-like effectors(TALEs)have been developed for DNA base editing in mitochondria of human cells and mice(Mok et al.,2020;Lee et al.,2021). | Riqing Li Si Nian Cha Bo Liu Hua Liu Xianran Li Bing Yang | 2021 | Molecular Plant2021，14，9： | 4 |
| 4 | Using Airgun Source Signals to Study Regional Wave Velocity Changes before and after the Yunlong M_S5.0 and Yangbi M_S5.1 Earthquakes显示文摘On the basis of the airgun source signals recorded by the stations from January,2016 to June,2017,we use cross-correlation detection technology to obtain the characteristics of the stable phase travel time change of each station.We used the Yunlong MS5.0 and Yangbi MS5.1 earthquakes as samples.According to regional characteristics,13 stations with high signal-to-noise ratios and complete data were selected(including 3 fixed stations and 10 active source stations).They are divided into four regions,and on the basis of the GNSS baseline data,the characteristics of regional wave velocity changes before and after the earthquake are analyzed.The results show that the station phase travel time change and the regional stress characteristics represented by the GNSS baseline data have good correlation in the short-term.Due to different degrees of regional stress,there are differences in the travel time changes of different stations in the four regions.Before the Yunlong MS5.0 and Yangbi MS5.1 earthquakes,with regional stress adjustment,there is an upward trend in the travel time changes of related stations in the adjacent areas of up to 0.02 s.The difference is that there are differences in the time nodes and duration of the travel time anomalies,and there is a reverse descent process after the Yangbi MS5.1 earthquake.There are different degrees of travel time fluctuations in the relevant stations before and after the two earthquakes,but the fluctuation range before and after the earthquake was small.Compared with the water level change of the reservoir,the adjustment of the regional stress is more likely to have a substantial impact on the travel time changes of the relevant stations. | YANG Jianwen LI Lei ZHANG Pengying YE Beng HE Yingwen CHEN Jia CHA Wenjian | 2019 | Earthquake Research in China2019，33，2： | 4 |
| 5 | Multifunctional SnO2/3D graphene hybrid materials for sodium-ion and lithium-ion batteries with excellent rate capability and long cycle life显示文摘 | Jung-ln Lee Junhua Song Younghwan Cha Shaofang Fu Chengzhou Zhu Xiaolin Li Yuehe Lin Min-Kyu Song | 2017 | Nano Research2017，10，12： | 2 |
| 6 | A Periodicity Analysis of the Light Curve of 3C 454.3显示文摘我们分析了 3C 的收音机光曲线 454.3 在频率从 Metsaehovi 收音机天文台的数据库的 22 和 37 GHztaken,和 quasi-periodicactivity 的发现证据。有很复杂的非正弦的变化的轻曲线表演伟人活动。Twopossible 时期,一很弱 1.57 ±之一 0.12 年并且一很强壮 6.15 ±之一 0.50 年被二个方法, Jurkevich 方法和力量一致地识别光谱评价。6.15 ±的 Theperiod 0.50 年与 Ciaramella 等以前报导的结果一致。并且韦布等。把二进制黑洞模型用于我们发现了黑洞的中央结构 1.53 x 10 ~ 集中 9 太阳的质量和 1.86 x 10 ~ 8 太阳的质量,并且预言下一收音机爆发是发生在 2006 三月和 4 月。 | Huai-Zhen Li Guang-Zhong Xie Shu-Bai Zhou Hong-Tao Liu Guang-Wei Cha Li Ma Li-Sheng Mao | 2006 | Chinese Journal of Astronomy and Astrophysics2006，6，4： | 2 |
| 7 | A theoretical and 1-D numerical investigation on a valve/valveless air-breathing pulse detonation engine显示文摘The important operating characteristics of pulsed Pressure Gain Combustion(PGC)propulsion are the pressure gain of the combustor component and the propulsive performance gain of the engine.A ramjet-type valve/valveless air-breathing pulsed detonation engine with a supersonic internal compression inlet is investigated.Based on an ideal thermal cycle,the ideal equivalent pressure ratios(pcb)of the Pulsed Detonation Combustor(PDC)are obtained theoretically which are directly related with the propulsive performance of the engine.By introducing an orifice loss model into the cycles,the critical pressure drop ratios through the orifice for the PDC achieving pressure gain and the engine achieving thrust gain are studied.More influencing factors are investigated by the use of a one-dimensional(1-D)numerical simulation model.The operating characteristics of the pulse detonation engine are investigated with changes of the valve type,the inlet/outlet area ratio of the PDC,the nozzle area ratio,and flight conditions.All these factors can affect pcbof the PDC,and pcbcan be optimized by changing the geometry of the engine.The most important influence parameter is the valve type.When using an orifice-type aerodynamic valve,simulation results show that the PDC cannot achieve the pressure gain characteristics.When a supersonic internal compression inlet is introduced to the engine,whether the Pulse Detonation Engine(PDE)can achieve thrust gain comparable with that of an ideal Brayton cycle engine not only is related to the pressure gain of the combustor,but also needs to optimize the engine structure to reduce the total pressure loss. | Hua QIU Cha XIONG Jianling LI | 2021 | Chinese Journal of Aeronautics2021，34，1： | 2 |
| 8 | Chitosan and β-cyclodextrin Microspheres as Pulmonary Sustained Delivery Systems显示文摘Chitosan andβ-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method.The characteristics,mucociliotoxicity,permeation rate and drug release were studied.The drug entrapments of microspheresⅠ,ⅡandⅢ were from 35.70%to 21.09% and 13.33%,while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities(0.34-0.48 g/cm3),appropriate diameters(3.35-3.94μm)and theoretical aerodynamics diameters(2.20-3.04μm).SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces.FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin.The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine.The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheresⅡ had a prolong release,providing the release of 72.00%in 12 h.The results suggestes that chitosan/β-cyclodextrin microspheresⅡare a promising carrier as sustained release for pulmonary delivery. | ZHANG Weifen CHEN Xiguang LI Piwu HE Qiangzhi ZHOU Huiyun CHA Dongsu | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 2 |
| 9 | The role of IL-8 in the SDF-1α/CXCR4-induced angiogenesis of laryngeal and hypopharyngeal squamous cell carcinoma显示文摘 | Kai-Chun Li Ying-Hsuan Huang Ching-Yin Ho Chia-Yu Chu Shih-Ting Cha Hung-Huey Tsai Jenq-Yuh Ko Cheng-Chi Chang Ching-Ting Tan | 2012 | Oral Oncology2012，，6： | 2 |
| 10 | Investigation of hot jet on active control of oblique detonation waves显示文摘The hot jet injection is utilized to actively control the oblique detonation wave,such as initiating and stabilizing an oblique detonation wave at a desired position that is shorter than the length of induction zone,and adjust the height of the oblique detonation wave at the exit of combustor when the oblique detonation wave engine is working on off-design flight conditions.The fifth order Weighted Essentially Non-Oscillatory(WENO)scheme and a two-step reversible reaction mechanism of the stoichiometric H_2/Air are adopted in the simulations.With the help of hot jet injection,the transition from inert oblique shock wave to the oblique detonation wave immediately occurs near the position of hot jet injection,and consequently the length of combustor can be reduced.The angle of oblique detonation wave also decreases as the hot jet injection approaches the nose of wedge.Additionally,the height of the oblique detonation wave at the exit of combustor can be flexibly adjusted,and also depends on the injection position and the strength of the hot jet.If the velocity of the hot jet is too weak to directly trigger the overall oblique detonation wave at the position of injection,increasing the injection pressure will improve the strength of the hot jet and results in a successful transition. | Hongbin LI Jianling LI Cha XIONG Wei FAN Lei ZHAO Wenhu HAN | 2020 | Chinese Journal of Aeronautics2020，33，3： | 2 |
| 11 | Electrochemical Sensors Applied for In vitro Diagnosis显示文摘Electrochemical sensing technology has received extensive attention from researchers for its unique detection and analysis methods as well as the promising applications in clinical diagnosis.Compared with other detection methods,such as capillary electrophoresis,high‐performance liquid chromatography and liquid chromatography-tandem mass spectrometry,the electrochemical sensor overcomes the disadvantages of expensive cost and complicated operation,as an ideal device for in vitro detection.In this article,we mainly introduce some methods for the detection of biologically important compounds and cancer biomarkers,and briefly summarize the characteristics of these methods at first.And then,we also focus on the latest research progress in the application of electrochemical sensing technology to biologically important compounds’and cancer biomarkers’detection.Finally,the development trend and challenges of electrochemical sensing technology for in vitro diagnosis are also prospected. | LI Duo WU Cha TANG Xuehui ZHANG Yue WANG Tie | 2021 | Chemical Research in Chinese Universities2021，37，4： | 2 |
| 12 | Comparative outcomes of subcutaneous and transvenous cardioverter-defibrillators显示文摘Background: The comparative outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous (T-ICD) have not been well studied. The aim of this study was to evaluate the safety and efficacy of currently available S-ICD and T-ICD. Methods: The study included 86 patients who received an S-ICD and 1:1 matched to those who received single-chamber T-ICD by gender, age, diagnosis, left ventricular ejection fraction (LVEF), and implant year. The clinical outcomes and implant complications were compared between the two groups. Results: The mean age of the 172 patients was 45 years, and 129 (75%) were male. The most common cardiac condition was hypertrophic cardiomyopathy (HCM, 37.8%). The mean LVEF was 50%. At a mean follow-up of 23 months, the appropriate and inappropriate ICD therapy rate were 1.2% vs. 4.7%(X^2= 1.854, P=0.368) and 9.3% vs. 3.5%(X^2 = 2.428, P = 0.211) in S-ICD and T-ICD groups respectively. There were no significant differences in device-related major and minor complications between the two groups (7.0% vs. 3.5%, X^2 = 1.055, P = 0.496). The S-ICD group had higher T-wave oversensing than T-ICD group (9.3% vs. 0%, X^2 = 8.390, P=0.007). Sixty-five patients had HCM (32 in S-ICD and 33 in T-ICD). The incidence of major complications was not significantly different between the two groups. Conclusions: The efficacy of an S-ICD is comparable to that of T-ICD, especially in a dominantly HCM patient population. The S-ICD is assodated with fewer major complications demanding reoperation. | Jin-Jun Liang Hideo Okamura Roshini Asirvatham Andrew Schneider David O. Hodge Mei Yang Xu-Ping Li Ming-Yan Dai Ying Tian Pei Zhang Bryan C. Cannon Cong-Xin Huang Paul A. Friedman Yong-Mei Cha | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 13 | Sulphur-TiO2 yolk-shell nanoarchi- tecmre with internal void space for long-cycle lithium-sulphur bat- teries显示文摘 | WEI S Z LI W CHA J J | 2013 | Nature Communications2013，4，： | 1 |
| 14 | Supplementing fat grafts with adipose stromal cells for cosmetic facial contouring显示文摘 | Li J Gao J Cha P | 2013 | Dermatol Surg2013，39，31： | 1 |
| 15 | Functional display of foreign protein on surface of coli using N-terminal domain of ice nucleation protein 显示文摘 | LI L KANGD G CHA H J | 2004 | Biotechnology and Bioengineering2004，85，2： | 1 |
| 16 | Sulphur-TiO2 yolk-shell nanoarchitecture with internal void space for long-cycle lithium- sulphur batteries显示文摘 | Seh Z W Li Weiyang Cha J J | 2013 | Nat Comm2013，4，： | 1 |
| 17 | Control of apoptosis and mitotic spindle cheekpoint by surriving 显示文摘 | Li F Ambrosini G Cha EY | 1998 | Nature1998，396，： | 1 |
| 18 | Sulphur-Ti O2 yolk-shell nanoarchitecture with internal void space for long-cycle lithium-sulphur batteries显示文摘 | Seh Z W Li W Y Cha J J | 2013 | Nature Communications2013，4，： | 1 |
| 19 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
| 20 | Functional Display of Foreign Protein on Surface of Escherichia coli Using N-terminal Domain of Ice Nucleation Protein显示文摘 | LI L KANG D G CHA H J | 2004 | Biotechnology Bioengineering2004，85，2： | 1 |
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