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| 1 | Using Airgun Source Signals to Study Regional Wave Velocity Changes before and after the Yunlong M_S5.0 and Yangbi M_S5.1 Earthquakes显示文摘On the basis of the airgun source signals recorded by the stations from January,2016 to June,2017,we use cross-correlation detection technology to obtain the characteristics of the stable phase travel time change of each station.We used the Yunlong MS5.0 and Yangbi MS5.1 earthquakes as samples.According to regional characteristics,13 stations with high signal-to-noise ratios and complete data were selected(including 3 fixed stations and 10 active source stations).They are divided into four regions,and on the basis of the GNSS baseline data,the characteristics of regional wave velocity changes before and after the earthquake are analyzed.The results show that the station phase travel time change and the regional stress characteristics represented by the GNSS baseline data have good correlation in the short-term.Due to different degrees of regional stress,there are differences in the travel time changes of different stations in the four regions.Before the Yunlong MS5.0 and Yangbi MS5.1 earthquakes,with regional stress adjustment,there is an upward trend in the travel time changes of related stations in the adjacent areas of up to 0.02 s.The difference is that there are differences in the time nodes and duration of the travel time anomalies,and there is a reverse descent process after the Yangbi MS5.1 earthquake.There are different degrees of travel time fluctuations in the relevant stations before and after the two earthquakes,but the fluctuation range before and after the earthquake was small.Compared with the water level change of the reservoir,the adjustment of the regional stress is more likely to have a substantial impact on the travel time changes of the relevant stations. | YANG Jianwen LI Lei ZHANG Pengying YE Beng HE Yingwen CHEN Jia CHA Wenjian | 2019 | Earthquake Research in China2019，33，2： | 4 |
| 2 | A thermosensitive chitosan-based hydrogel for controlled release of insulin显示文摘现在的学习为胰岛素的控制版本在综合瞄准 thermosensitive hydrogel。根据一个修改方法, hydroxybutyl chitosan (HBC ) hydrogel 拥有了热敏感被准备它能在 25T 上形成 hydrogel | Ting-Ting GAO Ming KONG Xiao-Jie CHENG Gui-Xue XIA Yuan-Yuan GAO Xi-Guang CHEN Dong Su CHA HyunJin PARK | 2014 | Frontiers of Materials Science2014，8，2： | 3 |
| 3 | One-year record of organic and elemental carbon in fine particles in downtown Beijing and Shanghai显示文摘 | Yang F. He K. Ye B. Chen X. Cha L. Cadle S. H. Chan T. Mulawa P. A | 2005 | Atmospheric Chemistry and Physics2005，，51： | 3 |
| 4 | Combination Therapy of Sophoraflavanone B against MRSA: In Vitro Synergy Testing显示文摘 | Su-Hyun Mun Ok-Hwa Kang Dae-Ki Joung Sung-Bae Kim Yun-Soo Seo Jang-Gi Choi Young-Seob Lee Seon-Woo Cha Young-Sup Ahn Sin-Hee Han Dong-Yeul Kwon Tzeng-Ji Chen | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 5 | Innovation Requirements and Progress of Dialysis Water Treatment System显示文摘With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more. | Jun Ke Lifong Yan Taksui Wong Bo Hu Shuang Cui Sibo Huang Aiyun Cha Jie Huang Hongwei Hu Dawen Yun Shaofeng Huang Jie Shu Mingming Ma Lianghong Yin Xiangnan Dong Chen Yun Zuhui Chen Fanna Liu | 2017 | 临床医学工程2017，24，S1： | 2 |
| 6 | Chitosan and β-cyclodextrin Microspheres as Pulmonary Sustained Delivery Systems显示文摘Chitosan andβ-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method.The characteristics,mucociliotoxicity,permeation rate and drug release were studied.The drug entrapments of microspheresⅠ,ⅡandⅢ were from 35.70%to 21.09% and 13.33%,while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities(0.34-0.48 g/cm3),appropriate diameters(3.35-3.94μm)and theoretical aerodynamics diameters(2.20-3.04μm).SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces.FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin.The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine.The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheresⅡ had a prolong release,providing the release of 72.00%in 12 h.The results suggestes that chitosan/β-cyclodextrin microspheresⅡare a promising carrier as sustained release for pulmonary delivery. | ZHANG Weifen CHEN Xiguang LI Piwu HE Qiangzhi ZHOU Huiyun CHA Dongsu | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 2 |
| 7 | The general geometrical models of the design and 2 - axis NC machining of a helical end - mill with constant pitch显示文摘 | REN Bing - Yin TANG Yu - Yong CHEN Cha - Kuang | 2001 | Material Processing Technology2001，115，3： | 2 |
| 8 | Metabotropic Glutamate Receptor 2/3 in the Hippocampus of Patients with Mesiel Temporal Lobe Epilepsy, and of Rats and Mice after Pilocarpine-lndueed Status Epilepticus 显示文摘 | Tang FR Cha SC Chen PM | 2004 | Epilepsy Res2004，59，23： | 1 |
| 9 | Electrokinetically driven flow mixing in microchannel with wavy surface 显示文摘 | CHEN Cha'o-Kuang CHO Ching-Chang | 2007 | Journal of Colloid and Interface Science2007，312，2： | 1 |
| 10 | Triple Mechanisms of Glyphosate-resistance in a Naturally Occurring Glyphosateresistant Plant Dicliptera chinensis 显示文摘 | YUAN C I CHAING M Y CHEN Y M | 2002 | Plant Sci2002，163，： | 1 |
| 11 | An 8-year retrcpective study: 1,100 patients re-ceiving 1,557 implants using the minimally invasive hydraulic si-nus condensing technique显示文摘 | Chen L Cha J | 2005 | J Periodontol2005，76，3： | 1 |
| 12 | Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging显示文摘 | Cha S Lupo JM Chen MH | 2007 | AJNR Am J Neuroradiol2007，28，6： | 1 |
| 13 | Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth显示文摘 | CHA TL QIU L CHEN CT WEN Y HUNG MC | 2005 | Cancer Res2005，65，： | 1 |
| 14 | An 8-year retrospective study: 1 100 patients receiving 1 557 implants using the minimally invasive hydraulic sinus condensing technique 显示文摘 | Chen L Cha J | 2005 | J Periodontol2005，76，3： | 1 |
| 15 | miR-107 promotestumor progression by targeting the let-7 microRNAin mice and humans 显示文摘 | Chen PS Su JL Cha ST | 2011 | J Clin Invest2011，121，9： | 1 |
| 16 | Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibihty- weighted contrast - enhanced perfusion MR imaging显示文摘 | Cha S Lupo JM Chen MH | 2007 | American Journal of Neuroradiology2007，28，6： | 1 |
| 17 | Targeted ablation of the histidine-rich Ca 2+ -binding protein (HRC) gene is associated with abnormal SR Ca 2+ -cycling and severe pathology under pressure-overload stress显示文摘 | Chang Sik Park Shan Chen Hoyong Lee Hyeseon Cha Jae Gyun Oh Sunghee Hong Peidong Han Kenneth S. Ginsburg Sora Jin Inju Park Vivek P. Singh Hong-Sheng Wang Clara Franzini-Armstrong Woo Jin Park Donald M. Bers Evangelia G. Kranias Chunghee Cho Do Han Kim | 2013 | Basic Research in Cardiology2013，，3： | 1 |
| 18 | Bifurcation Analysis in Flexible Rotor Supported by Active Magnetic Bearing显示文摘 | Ming-Jyi Jang Cha'O-Kuang Chen | 2001 | International Journal of Bifurcation and Chaos2001，11，8： | 1 |
| 19 | A study on analyzing the problem of the spherical form error显示文摘 | Cha' o-Kuang Chen Chien-Hong Liu | 2000 | Precision Engi- neering2000，24，： | 1 |
| 20 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
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