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| 1 | ABA Signaling in Guard Cells Entails a Dynamic Protein-Protein Interaction Relay from the PYL-RCAR Family Receptors to Ion Channels显示文摘植物荷尔蒙 abscisic 酸(骆驼毛的织物) 用作象干旱那样的环境压力的一个综合者由在警卫房间调整特定的离子隧道触发有气孔的闭合。我们以前报导了那 SLAC1,为有气孔的闭合要求的一条外面的阴离子隧道,经由包含表明部件,包括的蛋白质磷酸酶 2C 成员和 SnRK2 类型 kinase (OST1 ) 的骆驼毛的织物的可逆蛋白质 phosphorylation 事件被调整。在这研究,我们重新组成从 PYL/RCAR-type 受体作为一个 proteinprotein 相互作用继电器表明小径的 ABA 到 PP2CSnRK2 phosphatasekinase 对,到离子隧道 SLAC1。骆驼毛的织物受体交往了与并且对 SnRK2 类型 kinase 禁止了 PP2C 磷酸酶活动,导致减少的警卫房间 turgor 和有气孔的闭合,释放活跃 SnRK2 kinase phosphorylate,并且激活 SLAC1 隧道。二混血儿的酵母和双分子的荧光互补试金被用来在小径在部件之中验证相互作用。这些生物化学的试金由他们的相互作用搭挡表明了磷酸酶和 kinases 的活动修正。SLAC1 隧道活动为发信号的小径的力量被用作端点读出,取决于表明部件的不同联合的存在。用 ABA 受体之一表明了那个变化的转基因的植物 overexpressing 的进一步的学习交往的搭挡的相对水平将变化骆驼毛的织物敏感。 | Sung Chul Lee Chae Woo Lim Wenzhi Lan Kai He Sheng Luan | 2013 | Molecular Plant2013，6，2： | 7 |
| 2 | Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation显示文摘Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive responses.However,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be defined.Here,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase HOS15.Upon ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress response.When the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via HOS15.Notably,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal onset.The unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of OST1.This model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization. | Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang Woo Sik Chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun | 2019 | Molecular Plant2019，12，11： | 5 |
| 3 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Tae Yoon Sun Min Lim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Mong Cho Jun Woo Lee Seung Up Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 4 | Six-Month Versus 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents: The Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) Randomized, Multicenter Study显示文摘 | Hyeon-Cheol Gwon Joo-Yong Hahn Kyung Woo Park Young Bin Song In-Ho Chae Do-Sun Lim Kyoo-Rok Han Jin-Ho Choi Seung-Hyuk Choi Hyun-Jae Kang Bon-Kwon Koo Taehoon Ahn Jung-Han Yoon Myung-Ho Jeong Taek-Jong Hong Woo-Young Chung Young-Jin Choi Seung-Ho Hur Hyuc | 2012 | Circulation2012，，3： | 1 |
| 5 | Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer显示文摘 | Hyun-Chul Lee Jong Gwang Kim Yee Soo Chae Sang Kyun Sohn Byung Woog Kang Joon Ho Moon Seong Woo Jeon Myung-Hoon Lee Kyoung-Hoon Lim Jin Young Park Gyu Seog Choi Soo-Han Jun | 2010 | Journal of Cancer Research and Clinical Oncology2010，，7： | 1 |
| 6 | Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer显示文摘 | Hyun-Chul Lee Jong Gwang Kim Yee Soo Chae Sang Kyun Sohn Byung Woog Kang Joon Ho Moon Seong Woo Jeon Myung-Hoon Lee Kyoung-Hoon Lim Jin Young Park Gyu Seog Choi Soo-Han Jun | 2010 | Journal of Cancer Research and Clinical Oncology2010，，7： | 1 |
| 7 | NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/β-catenin signaling显示文摘 | Jong-Tae Kim Jae Wha Kim Yun Hee Kang Kwang Dong Kim Seon-Jin Lee Seung-Chul Choi Kwang Soo Kim Suhn-Kee Chae Jung Woo Kim Jong-Seok Lim Hee Gu Lee | 2012 | FEBS Letters2012，，22： | 1 |
| 8 | Detent Force Minimization Techniques in Permanent Magnet Linear Synchronous Motors 显示文摘 | Ki - Chae Lim Joon - Keun Woo Gyu - Hung Kang | 2002 | IEEE TRANSACTIONS ON MAGNETICS2002，38，2： | 1 |
| 9 | Characterization of a cDNA encoding cysteine proteinase inhibitor from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds显示文摘 | Chae Oh Lim Soo In Lee Woo Sik Chung Sung Han Park Inhwan Hwang Moo Je Cho | 1996 | Plant Molecular Biology1996，，2： | 1 |
| 10 | Isolation and functional analysis of a pepper lipid transfer protein Ⅲ (CALTP Ⅲ )gene promoter during signaling to pathogen 显示文摘 | Jung Ho Won Lim Chae Woo Hwang Byung Kook | 2006 | Plant Science2006，170，： | 1 |
| 11 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Tae Yoon Sun Min Lim Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Mong Cho Jun Woo Lee Seung Up Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 12 | Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin显示文摘 | Jong Gwang Kim Yee Soo Chae Sang Kyun Sohn Joon Ho Moon Hun Mo Ryoo Sung Hwa Bae YoonSeop Kum Seong Woo Jeon Kyoung-Hoon Lim Byung-Mo Kang In-Ja Park Gyu Seog Choi Soo-Han Jun | 2009 | Cancer Chemotherapy and Pharmacology2009，，5： | 1 |
| 13 | Mononeuropathy multiplex associated with systemic vasculitis:A case report显示文摘BACKGROUND Vasculitis,a systemic disorder with inflammation of blood vessel walls,can develop broad spectrum of signs and symptoms according to involvement of various organs,and therefore,early diagnosis of vasculitis is challenging.We herein describe a patient who developed a special case of systemic vasculitis with mononeuropathy multiplex,rectal perforation and antiphospholipid syndrome(APS)presented with pulmonary embolism.CASE SUMMARY A 61-year-old woman visited hospital with complaints of myalgia and occasional fever.She was initially diagnosed as proctitis and treated with antibiotics,however,there was no improvement.In addition,she also complained right foot drop with hypesthesia,and left 2^(nd) and 3^(rd) finger tingling sensation.She underwent nerve conduction study for evaluation,and it revealed sensorimotor polyneuropathy in the left arm and bilateral legs.Subsequent sural nerve biopsy strongly suggested vasculitic neuropathy.Based on nerve biopsy and clinical manifestation,she was diagnosed with vasculitis and treated with immunosuppressive therapy.During treatment,sudden rectal perforation and pulmonary thromboembolism occurred,and further laboratory study suggested probable concomitant APS.Emergency Hartmann operation was performed for rectal perforation,and anti-coagulation therapy was started for APS.After few cycles of immunosuppressive therapy,tingling sensation and weakness in her hand and foot had been partially recovered and vasculitis was considered to be stationary.CONCLUSION Vasculitis can be presented with a variety of signs and symptoms,therefore,clinicians should always consider the possibility of diagnosis. | Hyun Jun Chae Jung Woo Kim Yae Lim Lee Jeong Hwan Park Sang Yoon Lee | 2021 | World Journal of Clinical Cases2021，9，7： | 0 |
| 14 | A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway显示文摘Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of lymphoma.Moreover,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib resistance.We developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in vivo.In rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and inflammation.KIC-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in ABC-DLBCLs.In addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 kinase.Our results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas. | Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
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