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| 1 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 2 | Electroconvulsive therapy and/or plasmapheresis in autoimmune encephalitis?显示文摘Autoimmune encephalitis is a poorly understood condition that can present with a combination of neurological and psychiatric symptoms, either of which may predominate. There are many autoantibodies associated with a variety of clinical syndromes-anti-N-Methyl-D-Aspartate receptor(NMDAR) is the commonest. Currently, the most widely used therapy is prompt plasmapheresis and steroid treatment(and tumour resection if indicated), followed by second line immunosuppression if this fails. Given the growing awareness of autoimmune encephalitis as an entity, it is increasingly important that we consider it as a potential diagnosis in order to provide timely, effective treatment. We discuss several previously published case reports and one new case. These reports examined the effects of electroconvulsive therapy(ECT) on patients with autoimmune encephalitis, particularly those in whom psychiatric symptoms are especially debilitating and refractory to standard treatment. We also discuss factors predicting good outcome and possible mechanisms by which ECT may be effective. Numerous cases, such as those presented by Wingfield, Tsutsui, Florance, Sansing, Braakman and Matsumoto, demonstrate effective use of ECT in anti-NMDAR encephalitis patients with severe psychiatric symptoms such as catatonia, psychosis, narcolepsy and stupor who had failed to respond to standard treatments alone. We also present a new case of a 71-year-old female who presented to a psychiatric unit initially with depression, which escalated to catatonia, delusions, nihilism and auditory hallucinations. After anti-NMDAR antibodies were isolated, she was treated by the neurology team with plasmapheresis and steroids, with a partial response. She received multiple sessions of ECT and her psychiatric symptoms completely resolved and she returned to her premorbid state. For this reason, we suggest that ECT should be considered, particularly in those patients who are non-responders to standard therapies. | Jessica L Gough Jan Coebergh Brunda Chandra Ramin Nilforooshan | 2016 | World Journal of Clinical Cases2016，4，8： | 8 |
| 3 | On solving the forward kinematics of 3RPR planar parallel manipulator using hybrid metaheuristics显示文摘 | CHANDRA R ROLLAND L | 2011 | Applied Mathematics and Compuation2011，217，： | 1 |
| 4 | Morphology and mechanical properties of intermetallic compounds in SnAgCu solderjoints显示文摘 | Chandra Rao B S S Weng J Shen L | 2010 | MicroelectronEngineering2010，87，11： | 1 |
| 5 | Differential display of genome subsets containing specific interspersed repeats显示文摘 | Broude N E Chandra A Smith C L | 1997 | Proceeding National Academy Sciences USA1997，94，： | 1 |
| 6 | An effcient method foraromatic Friedel-Crafts alkylation, acylation, benzoylation, andsulfonylation reactions显示文摘 | Singh R P Kamble R M Chandra K L | 2001 | Tetrahedron2001，57，： | 1 |
| 7 | Comparing EBLUP and CEBLUP for small area estimation显示文摘 | Chandra H Chambers R L | 2005 | Statistics in Transition2005，，7： | 1 |
| 8 | The mid-latitude total ozone trends in the northern hemisphere显示文摘 | Chandra S Varotsos C Flynn L E | 1996 | Geophys Res Letts1996，23，5： | 1 |
| 9 | Morphology and mechanical properties of intermetallic compounds in Sn-Ag-Cu solder joints显示文摘 | Chandra Rao B S S Weng J Shen L | 2010 | Microelectronic Engineering2010，87，11： | 1 |
| 10 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 11 | Elastic properties of the human chest during cardiopulmonary resuscitation显示文摘 | TSITLIK J E WEISFELDT M L CHANDRA N | 1983 | Crit Care Med1983，11，9： | 1 |
| 12 | Maternal serum creatine kinase as a biochemical marker of tubal pregnancy显示文摘 | Chandra L Jain A | 1995 | Int J Gynaecol Obstet1995，49，1： | 1 |
| 13 | From ab initio quantum chemistry to molecular dynamics: The delicate case of hydrogen bonding in ammonia显示文摘 | Boese A D Chandra A Martin J M L | 2003 | J Chem Phys2003，119，12： | 1 |
| 14 | Oxidation of some sugars with copper(III)显示文摘 | CHANDRA S YADAVA K L | 1968 | Talanta1968，15，： | 1 |
| 15 | Uplift capacity of pile group an- chars 显示文摘 | Vanitha L Patra N R Chandra S | 2007 | 25 ( 3 ) : 339 -3472007，25，3： | 1 |
| 16 | Development of carbon nanotubes and nanofluids based microbial fuel cell 显示文摘 | Tushar S Reddy A L M Chandra T S | 2008 | Int J Hydrogen Energy2008，33，22： | 1 |
| 17 | Morphology and mechanical properties of intermetaUic compounds in SnAgCu solder joints显示文摘 | Chandra Rao B B S Weng J Shen L | 2010 | Microelectronic Engineering2010，87，： | 1 |
| 18 | Fibre size does not appear to influence the ease of enzymatic hydrolysis of organosolv-pretreated softwoods显示文摘 | De1 Rio L F Chandra R P Saddler J N | 2012 | Bioresour Technol2012，107，： | 1 |
| 19 | Optimizing information efficiency in a direct-sequence mobile packet radio network显示文摘 | Madhavi W Chandra Brian L Hughes | 2003 | IEEE Tran on Commun2003，51，1： | 1 |
| 20 | Evidence for a mechanically induced oxidative burst显示文摘 | Yahraus T Chandra S Legendre L | 1995 | Plant Physiol1995，109，： | 1 |
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