|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 3 | Lattice Boltzmann Flux Solver:An Efficient Approach for Numerical Simulation of Fluid Flows显示文摘A lattice Boltzmann flux solver(LBFS)is presented for simulation of fluid flows.Like the conventional computational fluid dynamics(CFD)solvers,the new solver also applies the finite volume method to discretize the governing differential equations,but the numerical flux at the cell interface is not evaluated by the smooth function approximation or Riemann solvers.Instead,it is evaluated from local solution of lattice Boltzmann equation(LBE)at cell interface.Two versions of LBFS are presented in this paper.One is to locally apply one-dimensional compressible lattice Boltzmann(LB)model along the normal direction to the cell interface for simulation of compressible inviscid flows with shock waves.The other is to locally apply multi-dimensional LB model at cell interface for simulation of incompressible viscous and inviscid flows.The present solver removes the drawbacks of conventional lattice Boltzmann method(LBM)such as limitation to uniform mesh,tie-up of mesh spacing and time interval,limitation to viscous flows.Numerical examples show that the present solver can be well applied to simulate fluid flows with non-uniform mesh and curved boundary. | Shu Chang Wang Y Yang L M Wu J | 2014 | Transactions of Nanjing University of Aeronautics and Astronautics2014，31，1： | 7 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 5 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 6 | 饲料中添加发酵豆粕对岩鱼生长性能、身体组成、抗氧化酶活性和抗病性能的影响显示文摘试验研究用发酵豆粕鱼料(FSM)代替常规鱼料(FM)对幼鱼期和生长期岩鱼(又名许氏鲆鲉)生长性能、身体组成、抗氧化酶活性和抗病能力的影响。FSM含量分别为0、8%、16%、24%和32%的等氮(51%)和等热量(MJ·kg^(-1))鱼料代替FM蛋白质含量约0、10%、20%、30%和40%的鱼料(分别为FSM0组、FSM8组、FSM16组、FSM24组和FSM32组)。每组鱼料分别饲喂3组幼生期岩鱼(1.2±0.04 g;EXPⅠ组)和3组生长期岩鱼(148.2±2.9 g;EXPⅡ组),2次·d^(-1),共8周。与FSM0组、FSM8组和FSM16组相比,饲喂FSM32组幼生期岩鱼的体增重(WG)显著降低。FSM16组、FSM24组和FSM32组的饲料效率(FE)和岩鱼蛋白质功效比值(PER)显著低于FSM0组和FSM8组。FSM24组的日采食量(DFI)显著低于FSM0组和FSM8组。但生长期岩鱼的生长性能和饲料利用率未表现出显著改变。FSM32组幼生期岩鱼的内脏指数(VSI)显著低于其他各组。FSM替代FM量达到40%,对幼生期和生长期岩鱼的整个身体和肌肉指标、氨基酸组成均无显著影响。与对照组相比,鱼料中含有FSM的生长期岩鱼的血清抗氧化酶活性显著提高。腹腔注射迟钝爱德华菌后存活的幼生期岩鱼不受饲料变化的影响。试验结果表明,FSM是一种成功的FM替代品,幼生期岩鱼鱼料中替代量可达10%,生长期岩鱼料中替代量达40%时,对其生长性能仍无不良影响。 | Sang M L Hamid M A Kyung H Chang | 2016 | 饲料博览2016，0，7： | 2 |
| 7 | Adaptive guaranteed cost control of systems with uncertain parameters显示文摘 | Chang M S L Peng T K C | 1972 | IEEE Transactions on Automatic Control1972，17，4： | 2 |
| 8 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 9 | Differentiating macroreentrant from focal atrial tachycardias’occurred after circumferential pulmona-ry vein isolation显示文摘 | Chang S L Tsao H M Lin Y J | 2011 | J Cardiovasc Electrophysiol2011，22，7： | 1 |
| 10 | Universal screening for biliary atresia using an infant stool color card in Taiwan显示文摘 | HSIAO C H CHANG M H CHEN H L | 2008 | Hepatology2008，47，4： | 1 |
| 11 | Catching Fe- based bulk metallic glass with combination of high glass forming ability, ultrahigh strength and good plasticity in Fe- Co-Nb-B system显示文摘 | Chang Z Y Huang X M Chen L Y | 2009 | Mater Sci Eng A2009，517，： | 1 |
| 12 | Analysis of the discrete-time bulk-service queue Geo/GY/1/N+B显示文摘 | Chaudhry M L Chang S H | 2004 | Operations Research Letters2004，32，4： | 1 |
| 13 | Fractionation of soil phosphorus显示文摘 | Chang S C M L Jackson | 1957 | Soil Sci1957，84，： | 1 |
| 14 | Material and electrical characterization of carbon-doped Ta2O5 films for embedded dynamic random access memory applications显示文摘 | Chu K Chang J P Steigerwald M L | 2002 | Journal of Applied Physics2002，91，1： | 1 |
| 15 | Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene显示文摘 | Li M Cheng L Chang B Wang Y | 2008 | Cancer Invest2008，6，9： | 1 |
| 16 | Dye-sensitized solar cells using ZnO-nanorod electrodes显示文摘 | HUANG L T HUANG S R CHANG M L | 2011 | Journal of the Chinese Che- mical Society2011，58，： | 1 |
| 17 | Seven new sesquiterpene gly- cosides from the root bark of Dictamnus dasycarpus 显示文摘 | Chang J Xuan L J Xu Y M | 2001 | J Nat Prod2001，64，7： | 1 |
| 18 | Recent trends and some applications of isothermal titration calorimetry in biotechnology显示文摘 | Roselin L S Lin M S Lin P H Chang Y Chen W Y | | 0，，01： | 1 |
| 19 | Fractionation of soil phosphorus显示文摘 | Chang S Jackson M L | 1957 | Soil science1957，84，2： | 1 |
| 20 | Peritoneal microvascu-lar endothelial function and the microinflammatorystate are associated with baseline peritoneal trans-port characteristics in uremic patients显示文摘 | Teng L Chang M Liu S | 2015 | Int UrolNephrol2015，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员