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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 3 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 4 | Cementation and diagenetic fluid of algal dolomites in the Sinian Dengying Formation in southeastern Sichuan Basin显示文摘The Sinian Dengying Formation in China hosts one of the oldest gas-bearing reservoirs in the world.With a long geological history,it has developed into the reservoir rocks,whose quality depends on chemical dissolution and cementation.Despite presence of cavities and pores in the algal dolomites of the Dengying Formation,they were mostly filled with various forms of dolomite cements.Therefore,the investigation of these dolomites and their evolution is significant for analyzing the mechanism of pore space preservation.There are five types of cements in the Dengying Formation,which were well sampled for lab measurements such as thin section,cathodeluminescence,minor elements,isotope analysis of carbon,oxygen and strontium,in attempt to explore the fillers' geochemical characteristics and the diagenetic fluids.They are characterized as follows:firstly,fibrous rim dolomite cement is a typical product formed at sea bottom,and geochemically very similar to the matrix(micrite and microcrystalline dolomite),which could be a reflection of the geochemical characteristics of water at that time;secondly,the diagenetic fluids of the foliated dolomite cements tend to be inheriting,derived from the shallow burial 'imprisoned' seawater;thirdly,fine-to medium-grained dolomite cements with fairly high strontium isotopes and low carbon and oxygen isotopes were precipitated chiefly in freshwater during the period of uplifting caused by Tongwan tectonic movement;fourthly,coarse-grained dolomite cements bear a relatively high percentage of Mn element,but low in Fe and Sr,with carbon and oxygen isotopes remarkably shifted to negative values,which all show that they are related to hydrocarbon maturation and migration,and corresponding Thermochemical Sulfate Reduction;lastly,saddle-shaped dolomite cements are hydrothermally associated,and they were formed in high-temperature brine,which had passed through the areas rich in radioactive strontium isotopes. | SHI ZeJin WANG Yong TIAN YaMing WANG ChangCheng | 2013 | Science China Earth Sciences2013，56，2： | 16 |
| 5 | Complex Least Squares Adjustment to Improve Tree Height Inversion Problem in PolInSAR显示文摘At present,the principal data processing methods involving complex observations are based on two strategies according to characteristics of the observation process,i.e.,step-by-step and direct resolution.However,these strategies have some limitations,e.g.they cannot consider statistical observation error information,redundant observations and so on.This paper applies least squares methods to complex data processing to extend surveying adjustment theory from real to complex number space.We compared the two adjustment criteria for a complex domain in a quantitative way.In order to understand the effectiveness of complex least squares,tree height inversion from PolInSAR data is taken as an example.We firstly established both a complex adjustment function model and a stochastic model for PolInSAR tree height inversion,and then applied the complex least squares method to estimate tree height.Results show that the complex least squares approach is reliable and outperforms other classic tree height retrieval methods;the method is simple and easy to implement. | Jianjun ZHU Qinghua XIE Tingying ZUO Changcheng WANG Jian XIE | 2019 | Journal of Geodesy and Geoinformation Science2019，2，1： | 12 |
| 6 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 7 | Influence of chromium modification on the properties of MnO_x-FeO_x catalysts for the low-temperature selective catalytic reduction of NO by NH_3显示文摘Catalytic properties of MnOx -FeOx complex oxide (hereafter denoted as Mn-Fe) catalysts modified with different loadings of chromium oxide were investigated by using the combination of physico-chemical techniques, such as N2 physisorption, X-ray diffraction (XRD), high-resolution transmission electron microscope (HRTEM), in situ Fourier transform infrared spectroscopy (in situ FT-IR) and temperature-programmed reduction (TPR) and their catalytic activities were evaluated with the selective catalytic reduction (SCR) of NOx by NH3 . It was found that with the addition of Cr, more NO could be removed in the low-temperature window (below 120℃). Among the tested catalysts, Mn-Fe-Cr (2 : 2 : 1) catalyst exhibited the best catalytic performance at 80℃ with the NO conversion higher than 90%. The combination of the reaction and characterization results indicated that (1) the strong interaction among tertiary metal oxides existed in the catalysts when Cr was appropriately added, which made the active components better dispersed with less agglomeration and sintering and the largest BET specific surface area could be obtained; (2) Cr improved the low-temperature reducibility of the catalyst and promoted the formation of the active intermediate (-NH+3 ), which favored the low-temperature SCR reaction. | Kai Shen Yaping Zhang Xiaolei Wang Haitao Xu Keqin Sun Changcheng Zhou | 2013 | Journal of Energy Chemistry2013，22，4： | 7 |
| 8 | Inversion of vegetation height from Pol In SAR using complex least squares adjustment method显示文摘In this paper, we propose the novel method of complex least squares adjustment(CLSA) to invert vegetation height accurately using single-baseline polarimetric synthetic aperture radar interferometry(Pol In SAR) data. CLSA basically estimates both volume-only coherence and ground phase directly without assuming that the ground-to-volume amplitude radio of a particular polarization channel(e.g., HV) is less than ?10 d B, as in the three-stage method. In addition, CLSA can effectively limit errors in interferometric complex coherence, which may translate directly into erroneous ground-phase and volume-only coherence estimations. The proposed CLSA method is validated with Bio SAR2008 P-band E-SAR and L-band SIR-C Pol In SAR data. Its results are then compared with those of the traditional three-stage method and with external data. It implies that the CLSA method is much more robust than the three-stage method. | FU HaiQiang WANG ChangCheng ZHU JianJun XIE QingHua ZHAO Rong | 2015 | Science China Earth Sciences2015，58，6： | 6 |
| 9 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 10 | Long-time precipitation reduction and nitrogen deposition increase alter soil nitrogen dynamic by influencing soil bacterial communities and functional groups显示文摘The effects of precipitation reduction and nitrogen deposition increase on soil bacterial communities and functions impact soil nitrogen cycling. Seasonal changes could modify the effects of precipitation reduction and nitrogen deposition increase on bacterial communities and functions by changing soil environments and properties. Understanding soil microbial communities and the seasonal response of functions to precipitation reduction and nitrogen deposition increase may be important for the accurate prediction of changes in the soil nitrogen dynamics. Thus, a long-term field simulation experiment of nitrogen deposition increase and throughfall exclusion was established to investigate soil bacterial communities’ response to nitrogen deposition increase and/or precipitation reduction, with no nitrogen deposition increase and no precipation reduction as a control, in a temperate forest. We examined soil bacterial communities(Illumina sequencing) under different treatments during the winter, freezing-thawing cycle periods(FTCs), and growing season. The bacterial functional groups were predicted by the FAPROTAX database. The results showed that nitrogen deposition increase, precipitation reduction, the combined effect of nitrogen deposition increase and precipitation reduction, and seasonal changes significantly altered the soil bacterial community composition.Interestingly, by combining the result of a previous study in which nitrogen deposition increase increased the nitrous oxide flux in the same experimental system, the loss of soil nitrogen was increased by the decrease in denitrification and increase of nitrification bacteria under nitrogen deposition increase,while ammonification bacteria significantly increased and N-fixing bacteria significantly decreased with precipitation reduction compared to the control. In relation to seasonal changes, the aromatic-degrading, cellulolytic, and ureolytic bacteria were lowest during FTCs, which indicated that FTCs might inhibit biodegradation. Nitrification and nitrite-oxidizing bacteria increased with nitrogen deposition increase or precipitation reduction and in FTCs compared to the control or other seasons. The interaction between treatment and season significantly changed the soil bacterial communities and functions. These results highlight that nitrogen deposition increase, precipitation reduction, seasonal changes, and their interactions might directly alter bacterial communities and indirectly alter the dynamics of soil N. | Guoyong YAN Yajuan XING Shijie HAN Junhui ZHANG Qinggui WANG Changcheng MU | 2020 | Pedosphere2020，30，3： | 6 |
| 11 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 12 | A Zernike-moment-based non-local denoising filter for cryo-EM images显示文摘Cryo-electron microscopy (cryo-EM) plays an important role in determining the structure of proteins, viruses, and even the whole cell. It can capture dynamic structural changes of large protein complexes, which other methods such as X-ray crystallography and nuclear magnetic resonance analysis find difficult. The signal-to-noise ratio of cryo-EM images is low and the contrast is very weak, and therefore, the images are very noisy and require filtering. In this paper, a filtering method based on non-local means and Zernike moments is proposed. The method takes into account the rotational symmetry of some biological molecules to enhance the signal-to-noise ratio of cryo-EM images. The method may be useful in cryo-EM image processing such as the automatic selection of particles, orientation determination, and the building of initial models. | WANG Jia YIN ChangCheng | 2013 | Science China(Life Sciences)2013，56，4： | 5 |
| 13 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 14 | Relationship between chronic diarrhea with normal colonoscopy findings and terminal ileum lesions显示文摘 | LI Hongling WANG Changcheng LIU Shuqing XU Dongsheng ZHANG Ju CHEN hongmei | 2014 | Chinese Medical Journal2014，，16： | 4 |
| 15 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 16 | The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)caused by the SARS-CoV-2 coronavirus has become a global pandemic.The SARS-CoV-2 genome has a similarity of 96.2%to that of RaTG13,a bat SARS-CoV-2-related coronavirus detected in Rhinolophus affinis(Paraskevis et al.,2020;Zhou et al.,2020).The SARS-CoV-2 genome also has 85.5%−92.4%sequence similarity to SARS-CoV-2-related coronaviruses from Malayan pangolins that have been seized in anti-smuggling operations in southern China(Guangdong-Pangolin(GD-Pangolin-CoV)and Guangxi-Pangolin(GX-Pangolin-CoV)genomes)(Liu et al.,2019;Lam et al.,2020). | Tao Li Xiaolu Tang Changcheng Wu Xinmin Yao Yirong Wang Xuemei Lu Jian Lu | 2020 | Science China(Life Sciences)2020，63，10： | 3 |
| 17 | Association of traditional Chinese exercises with glycemic responses in people with type 2 diabetes:A systematic review and meta-analysis of randomized controlled trials显示文摘Background: There is increasing evidence showing the health benefits of various forms of traditional Chinese exercises(TCEs) on the glycemic profile in people with type 2 diabetes. However, relatively little is known about the combined clinical effectiveness of these traditional exercises.This study was designed to perform a systematic review and meta-analysis of the overall effect of 3 common TCEs(Tai Ji Quan, Qigong, Ba Duan Jin) on glycemic control in adults with type 2 diabetes.Methods: We conducted an extensive database search in Cochrane Library, EMBASE, Pub Med, Web of Science, EBSCO, and China National Knowledge Infrastructure on randomized controlled trials published between April 1967 and September 2017 that compared any of the 3 TCEs with a control or comparison group on glycemic control. Data extraction was performed by 2 independent reviewers. Study quality was evaluated using the Cochrane Handbook for Systematic Reviews of Interventions, which assessed the risk of bias, including sequence generation, allocation concealment, blinding, completeness of outcome data, and selective outcome reporting. The resulting quality of the reviewed studies was characterized in 3 grades representing the level of bias: low, unclear, and high. All analyses were performed using random effects models and heterogeneity was quantified. We a priori specified changes in biomarkers of hemoglobin A1 c(in percentage) and fasting blood glucose(mmol/L) as the main outcomes and triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein-cholesterol, 2-h plasma glucose, and fasting plasma glucose as secondary outcomes.Results: A total of 39 randomized, controlled trials(Tai Ji Quan = 11; Qigong = 6; Ba Duan Jin = 22) with 2917 type 2 diabetic patients(aged41à80 years) were identified. Compared with a control or comparison group, pooled meta-analyses of TCEs showed a significant decrease in hemoglobin A1 c(mean difference(MD) = ?0.67%; 95% confidence interval(CI): ?0.86% to ?0.48%; p < 0.00001) and fasting blood glucose(MD = ?0.66 mmol/L; 95%CI: ?0.95 to ?0.37 mmol/L; p < 0.0001). The observed effect was more pronounced for interventions that were medium range in duration(i.e., >3à<12 months). TCE interventions also showed improvements in the secondary outcome measures. A high risk of bias was observed in the areas of blinding(i.e., study participants and personnel, and outcome assessment).Conclusion: Among patients with type 2 diabetes, TCEs were associated with significantly lower hemoglobin A1 c and fasting blood glucose.Further studies to better understand the dose and duration of exposure to TCEs are warranted. | ge song changcheng chen juan zhang lin chang dong zhu xueqiang wang | 2018 | Journal of Sport and Health Science2018，7，4： | 3 |
| 18 | Evolution of the Xiaotian-Mozitan fault and its implications for exhumation of Dabie HP-UHP rocks显示文摘The Xiaotian-Mozitan fault(XMF)located north of the Dabie orogenic belt separates the North Dabie complex to the south from the Beihuaiyang low-grade metamorphic rocks to the north.It comprises several NW-striking ductile shear zones and brittle faults.The brit-tle faults obviously overprinted on the ductile shear zones and promoted the development of the volcanic basins in early Cretaceous to the north,which suggests that the brittle faults were normal faults formed in early Cretaceous during doming of the Dabie orogenic belt.The ductile shear zone superposed on the north Dabie gray gneiss,and it is an important channel where the Dabie HP-UHP rocks exhumed.For obtaining new structural constraint on exhumation of the HP-UHP rocks,we present here experimental results on the microstructure,quartz C-axis fabrics and the microprobe analyses of phengite.The ductile shear zone was determined to be formed at a temperature of 600-650°C and pressure of 1.1 GPa by the mineral deformation,microprobe analyses and geobarometry of Si-in-phengite of the mylonite,the results suggest that the mylonite now exposed on the surface experienced an upper amphibolite-facies metamorphism in the lower crust.The mineral stretching lineation varies from horizontal in the east segment to sub-dip in the west.Shear sense indicators from outcrop and thin sections of orientated specimen and quartz C-axis fabrics suggest that the XMF is a sinis-tral normal fault.The kinematics analysis of the ductile shear zone indicates that the exhumation of Dabie HP-UHP rocks is the results of a SE-directed extrusion and an anticlockwise rotation around its eastern pivot simultaneously. | Biwei Xiang Yongsheng Wang Changcheng Li Guang Zhu Yonghong Shi | 2008 | Progress in Natural Science:Materials International2008，18，6： | 3 |
| 19 | The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study显示文摘Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;www.who.int/ictrp. | Liming Wang Yunhe Liu Weiqi Rong Fan Wu Weibo Yu Kan Liu Shengtao Lin Yiling Zheng Kai Zhang Tana Siqin Changcheng Tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 2 |
| 20 | 显示恶性孤立肺结节分叶征的理想CT层厚(英文)显示文摘Objective: The aim of this study was to determine an optimal slice thickness that was efficient in revealing lobulation of malignant solitary pulmonary nodules (SPNs) on multi-slice spiral computed tomography (MSCT) images preliminarily. Methods: Fifty patients with malignant SPNs (diameter ≤ 3 cm) underwent multidetector-row computed tomography of the chest in a single-breath-hold technique. The raw data were acquired with a collimation of 0.625 mm. Three sets of contiguous images were reconstructed with 1-, 2-, and 5-mm slice thickness, respectively. The lobulation sign of SPNs on the computed tomography (CT) images presented in 1-, 2-, and 5-mm slice thickness was compared. Using the 1-mm sections as the gold standard, an optimal slice thickness in revealing lobulation sign of SPNs was determined. Results: The 1-mm-thick images CT revealed 98 lobulations (25 with chord distance < 1 mm; 30 with chord distance 1-2 mm; 43 with chord distance > 2 mm) of 45 malignant SPNs. 18 lobulations with chord distance < 1 mm presented in 2-mm-thick sections were as same as those in 1-mm-thick sections. Statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.023 < 0.05). 16 lobulations with chord distance < 1 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.004 < 0.05). The 24 lobulations with chord distance 1-2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number were found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.261 > 0.05). 13 lobulations with chord distance 1-2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.003 < 0.05). 40 lobulations with chord distance ﹥2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.631 > 0.05). 36 lobulations with chord distance ﹥2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was no statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.264 > 0.05). Conclusion: It is suggested that the use of 1-mm slice thickness is suitable in revealing lobulations with chord distance < 1 mm. A 2-mm slice thickness is suggested to be used in revealing lobulations with chord distance 1-2 mm and 5-mm slice thickness to be used in revealing lobulations with chord distance > 2 mm. | Shenjiang Li Changcheng Li Xin Wang Debin Liu Wenjie Liang Feng Zhu Yan Zhu Xuefeng Cui Wenjie Bi | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 2 |
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